Werner & Ingbaru2019s The Thyroid: A Fundamental and Clinical Text, 10th Edition has been extensively revised and streamlined to deliver the most comprehensive coverage of the thyroid including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Entirely new chapters on the surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs are in this edition. New authors and an international group of contributors elevate this classic text that includes extensive clinical coverage of thyroid dysfunctionu2019s effects on other organ systems. Also addressed are clinical controversies regarding the ageing thyroid, subclinical hypothyroidism and hyperthyroidism and thyroid disease in pregnancy.
New to this edition:
· Twenty-three chapters authored by new contributors and international experts
· A companion website with fully searchable text for quick reference
· Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field
SECTION I. THE NORMAL THYROID Â PART A. HISTORY, DEVELOPMENT, ANATOMY Â Chapter 1 The Heritage of the Thyroid: A Brief History Clark T. Sawin Â Chapter 2 Development of the Hypothalamic–Pituitary–Thyroid Axis Pilar Santisteban Â Chapter 3 Anatomy and Pathology of the Thyrotrophs Fabio Rotondo, Kalman Kovacs, and Eva Horvath Â PART B. THYROID HORMONE SYNTHESIS AND SECRETION Â Chapter 4A Thyroid Hormone Synthesis: Thyroid Iodide Transport Nancy Carrasco Â Chapter 4B Thyroid Hormone Synthesis Peter Kopp Â Chapter 5 Thyroglobulin Structure, Function, and Biosynthesis Hu00e9ctor M. Targovnik Â PART C. PERIPHERAL THYROID HORMONE BINDING AND METABOLISM Â Chapter 6 Thyroid Hormone Transport Proteins and the Physiology of Hormone Binding Salvatore Benvenga Â Chapter 7 Intracellular Pathways of Iodothyronine Metabolism/Implications of Deiodination for Thyroid Hormone Action Antonio C. Bianco and Brian W. Kim Â PART D. THYROID HORMONE ACTION Â Chapter 8 Genomic and Nongenomic Actions of Thyroid Hormones Paul M. Yen and Gregory A. Brent Â Chapter 9 Thyroid Hormone Structure–Function Relationships Stephen D. Ayers, John D. Baxter, and Paul Webb Â PART E. FACTORS THAT CONTROL THYROID FUNCTION Â Chapter 10A Chemistry and Biosynthesis of Thyrotropin Ronald N. Cohen and Fredric E. Wondisford Â Chapter 10B The Thyrotropin Receptor Gilbert Vassart Â Chapter 10C Regulation of Thyrotropin Secretion Anthony N. Hollenberg Â Chapter 11A Age Related Changes in Thyroid Function Laura Boucai and Martin I. Surks Â Chapter 11B Effects of Drugs on TSH Secretion, Thyroid Hormones Absorption, Synthesis, Metabolism, and Action Su00b4ebastien Thalmann and Christoph A. Meier Â Chapter 11C Nonthyroidal Illness Syndrome Wilmar M. Wiersinga and Greet Van den Berghe Â Chapter 11D Iodine Deficiency and Endemic Cretinism Michael Zimmerman Â Chapter 11E Effect of Excess Iodide: Clinical Aspects Elio Roti and Apostolos G. Vagenakis Â Â SECTION II. ASSESSMENT OF THYROID STRUCTURE AND FUNCTION Â Chapter 12 Thyroid Radionuclide Uptake and Imaging Studies Richard L. Wahl Â Chapter 13A Measuring Serum Thyroid–Stimulating Hormone, Thyroid Hormones, Thyroid-Directed Antibodies, and Transport Proteins Offie P. Soldin Â Chapter 13B Measurement of Thyroglobulin Carole Ann Spencer Â Chapter 14 Nonisotopic Techniques of Thyroid Imaging Laszlo Hegeduu00a8 s and Finn Noe Bennedbaek Â Chapter 15 Physical Examination of the Thyroid Gland James V. Hennessey Â Chapter 16 Pathology and Cytopathology Zubair Wahid Baloch and Virginia A LiVolsi Â Â SECTION III. THYROID DISEASES: THYROTOXICOSIS Â Chapter 17 Introduction to Thyrotoxicosis Lewis E. Braverman and David S. Cooper Â PART A. CAUSES OF THYROTOXICOSIS Â Chapter 18A Pathogenesis of Gravesâ€™ Disease Terry F. Davies Â Chapter 18B Ophthalmopathy Petros Perros and Jane Dickinson Â Chapter 18C Thyroid Dermopathy and Thyroid Acropachy Vahab Fatourechi Â Chapter 19 Thyrotropin-Induced Thyrotoxicosis Paolo Beck-Peccoz and Luca Persani Â Chapter 20 Toxic Adenoma and Toxic Multinodular Goiter Ralf Paschke Â Chapter 21 Trophoblastic Tumors Jerome M. Hershman Â Chapter 22 Sporadic Painless, Painful Subacute and Acute Infectious Thyroiditis Alan P. Farwell Â Chapter 23 Thyrotoxicosis of Extrathyroid Origin Angela M. Leung and Joshua D. Safer Â PART B. ORGAN SYSTEM MANIFESTATIONS Â Chapter 24 Overview of the Clinical Manifestations of Thyrotoxicosis Henry B. Burch Â Chapter 25 The Cardiovascular System in Thyrotoxicosis Irwin Klein and Sara Danzi Â Chapter 26 Thyroid Hormones in Thermogenesis, Intermediary Metabolism, and Obesity Thomas Reinehr Â Chapter 27 The Male and Female Reproductive System in Thyrotoxicosis Gerasimos E. Krassas and Nikolaos Pontikides Â Chapter 28 The Skeletal System in Thyrotoxicosis Graham R. Williams Â Chapter 29 Behavioral and Psychiatric Aspects of Thyrotoxicosis Michael Bauer, Mary Samuels, and Peter C. Whybrow Â Chapter 30 Thyrotoxic Storm Leonard Wartofsky Â PART C. DIAGNOSIS AND MANAGEMENT OF THYROTOXICOSIS Â Chapter 31 Diagnosis of Thyrotoxicosis Paul W. Ladenson Â Chapter 32 Treatment of Thyrotoxicosis David S. Cooper Â Chapter 33 Subclinical Thyrotoxicosis Douglas S. Ross Â Â SECTION IV. THYROID DISEASES: HYPOTHYROIDISM Â Chapter 34 Introduction to Hypothyroidism Lewis E. Braverman and David S. Cooper Â PART A. CAUSES OF HYPOTHYROIDISM Â Chapter 35 Chronic Autoimmune Thyroiditis Anthony P. Weetman Â Chapter 36 Genetic Defects Causing Hypothyroidism Thomas Vulsma and Jan J.M. de Vijlder Â Chapter 37 Primary Hypothyroidism Due to Other Causes Peter A. Singer Â Chapter 38 Central Hypothyroidism Luca Persani and Paolo Beck-Peccoz Â PART B. ORGAN SYSTEM MANIFESTATIONS OF HYPOTHYROIDISM Â Chapter 39 Overview of the Clinical Manifestations of Hypothyroidism Michael T. McDermott Â Chapter 40 The Cardiovascular System in Hypothyroidism Irwin Klein and Sara Danzi Â Chapter 41 The Male and Female Reproductive System in Hypothyroidism Gerasimos E. Krassas and Nikolaos Pontikides Â Chapter 42 The Skeletal System in Hypothyroidism Graham R. Williams Â Chapter 43 Psychiatric and Cognitive Effects of Hypothyroidism Kathryn G. Schuff, Mary H. Samuels, Peter C. Whybrow, and Michael Bauer Â Chapter 44 Myxedema Coma Leonard Wartofsky Â PART C. MANAGEMENT OF HYPOTHYROIDISM Â Chapter 45 Diagnosis of Hypothyroidism Paul W. Ladenson Â Chapter 46 Treatment of Hypothyroidism Jacqueline Jonklaas Â Chapter 47 Subclinical Hypothyroidism Douglas Ross Â Â SECTION V. THYROID DISEASES: NONTOXIC DIFFUSE AND MULTINODULAR GOITER Â Chapter 48 Multinodular Goiter: Pathogenesis and Management Hans Graf Â Chapter 49 Clinical Evaluation and Management of Thyroid Nodules Susan J. Mandel, Jill E. Langer, and Michael M. Kaplan Â Â SECTION VI. THYROID CANCERS Â Chapter 50A Carcinomas of Follicular Epithelium: Epidemiology and Pathogenesis Arthur B. Schneider and Alina V. Brenner Â Chapter 50B Molecular Genetics of Tumors of Thyroid Follicular Cells James A. Fagin and Yuri Efimovich Nikiforov Â Chapter 50C Carcinoma of the Follicular Epithelium: Surgical Therapy Gregory W. Randolph and Gerard M. Doherty Â Chapter 50D Staging and Prognosis of Differentiated Thyroid Cancer Richard Kloos Â Chapter 50E Medical Management of Differentiated Epithelial Cell Thyroid Cancer Sebastiano Filetti, R. Michael Tuttle, and Steven I. Sherman Â Chapter 51 Medullary Thyroid Carcinoma Mimi I. Hu, Camilo Jimenez, Gilbert J. Cote, and Robert F. Gagel Â Chapter 52 Anaplastic Thyroid Cancer and Miscellaneous Tumors of the Thyroid Joshua P. Klopper, Madeleine A. Kane, and Bryan R. Haugen Â Â SECTION VII. THE THYROID IN INFANCY AND CHILDHOOD Â Chapter 53 The Maturation of Thyroid Function in the Perinatal Period and During Childhood Delbert A. Fisher and Rosalind S. Brown Â Chapter 54A Hypothyroidism in Infants and Children:Neonatal Screening Guy Van Vliet and Johnny Deladoey Â Chapter 54B Hypothyroidism in Infants and Children: Congenital Hypothyroidism Guy Van Vliet and Johnny Deladoey Â Chapter 54C Hypothyroidism in Infants, Children, and Adolescents: Acquired Hypothyroidism Guy Van Vliet and Johnny Deladoey Â Chapter 55 Hyperthyroidism in the Neonatal Period and Childhood Stephen H. LaFranchi and Cheryl