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Now in its second edition utilizing brand new clinical case material, this popular, user-friendly text presents the diagnosis and treatment of thyroid cancer and related clinical issues, providing clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various manifestations of thyroid cancer that they may encounter. Each chapter is a case report that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature.
Written by experts in the field, these cases illustrate treatment for both low- and high-risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer and anaplastic thyroid cancer. Topics new to the second edition include information on management of small thyroid cancers with “active surveillance” (without surgery), new chemotherapeutic approaches to advanced thyroid cancer, and new information on a lesion that is no longer considered to be thyroid cancer (Neoplastic Follicular Thyroid Neoplasm with Papillary-Like Features [NIFTP]), as well as material on external beam radiotherapy and new approaches to the management of anaplastic thyroid cancer.
Pragmatic and reader-friendly, this second edition of Thyroid Cancer: A Case-Based Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike.
A Patient with a Single Thyroid Nodule Suspicious for Follicular Neoplasm According to the Bethesda System for Reporting Thyroid Cytopathology: Molecular Evaluation
Pages 3-12
Desai, Dimpi (et al.)
A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer
Pages 13-17
Grani, Giorgio (et al.)
A Case of a Small (1–2 cm) Papillary Thyroid Cancer in a Young Patient: Lobectomy Versus Total Thyroidectomy
Pages 19-24
Doherty, Gerard M.
A Patient with Papillary Microcarcinoma Undergoing Active Surveillance
Pages 25-33
Boucai, Laura
Completion Thyroidectomy in a Patient with Low-Risk Papillary Cancer
Pages 35-40
Cooper, David S.
Papillary Thyroid Cancer with Microscopic Extra-thyroidal Extension
Pages 41-53
McLeod, Donald S. A.
A Small Papillary Thyroid Cancer with Angioinvasion
Pages 55-58
Hopkins, Michael E. (et al.)
A Patient with a Pathological Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)
Pages 59-67
Carruthers, David (et al.)
Papillary Thyroid Cancer with Central Neck Lymph Node Metastases
Pages 69-80
Goldberg, Alyse S. (et al.)
A Patient with a Large Minimally Invasive Follicular Thyroid Cancer
Pages 81-92
Kim, Jina (et al.)
An Adolescent with Papillary Thyroid Carcinoma and Locally Metastatic Disease but No Distant Metastases
Pages 93-102
Bottomley, Sarah J. (et al.)
A Patient with Papillary Thyroid Cancer and Biochemical Evidence of Possible Residual Disease at the One-Year Follow-Up Visit
Pages 105-112
Ramundo, Valeria (et al.)
A Patient with Low-Risk Papillary Thyroid Cancer Who Has Undergone a Lobectomy: Monitoring for Recurrent Disease and Assessment of Thyroid Function
Pages 113-117
Vaisman, Fernanda (et al.)
A Patient with Papillary Thyroid Carcinoma and Biochemical Evidence of Disease at Follow-Up Visits and Increasing Serum Tg Values at Follow-Up Assessments
Pages 119-129
Ito, Yasuhiro (et al.)
A Young Patient with Recurrent Lymph Node Involvement: Imaging, Cytology, and Thyroglobulin Washout
Pages 131-138
Ramundo, Valeria (et al.)
Papillary Thyroid Carcinoma Diagnosed During Pregnancy
Pages 141-145
Simons, Zachary (et al.)
Risks of Thyroid Hormone Suppression for Differentiated Thyroid Cancer in the Elderly
Pages 147-157
Yalamanchi, Swaytha (et al.)
A Case with Postsurgical Hypoparathyroidism: Treatment Options
Pages 159-166
Pepe, Jessica (et al.)
A Patient with Postsurgical Recurrent Laryngeal Nerve Damage and Nerve Monitoring
Pages 167-178
Steward, David L. (et al.)
A Case of Papillary Thyroid Cancer Without Aggressive Histological Features with a Nodal Metastasis Detected During Follow-Up in a Young Patient
Pages 181-185
Brilli, Lucia (et al.)
A Patient with a Large Hürthle Cell Carcinoma of the Thyroid and Nodal Metastases
Pages 187-193
Wartofsky, Leonard
A Case of a Large, Invasive PTC with Gross Residual Disease (pT4) After Surgery
Pages 195-200
Giuliani, Meredith (et al.)
A Patient with Papillary Carcinoma of the Thyroid with Elevated Serum Thyroglobulin but Negative Imaging Studies
Pages 201-207
Wartofsky, Leonard
A Child with Papillary Thyroid Cancer and Metastatic Pulmonary Disease: Role of Radioactive Iodine Therapy
Pages 209-219
Arango, Monica L. (et al.)
A Patient with Bone Metastases from Follicular Carcinoma of the Thyroid
Pages 221-229
Wartofsky, Leonard
Radioiodine Therapy in Lactating Women with Higher-Risk Differentiated Thyroid Cancer
Pages 231-238
Yalamanchi, Swaytha (et al.)
A Case of a Patient with RAI-Refractory Differentiated Thyroid Cancer with Progressive Neck Disease and Stable Lung Metastases
Pages 241-248
Hartl, Dana M. (et al.)
A Case of Fistula After Adjuvant External Beam Radiotherapy and Lenvatinib for High-Risk Follicular Thyroid Cancer
Pages 249-260
Kut, Carmen (et al.)
RAI Refractory Differentiated Thyroid Cancer with Multiple-Organ Progressive Disease
Pages 261-268
Sherman, Steven I.
RAI-Refractory Differentiated Thyroid Cancer and Lung Lesions Causing Bleeding
Pages 269-273
Sherman, Steven I.
A Patient with Follicular Thyroid Cancer and a Painful Bone Metastases at Risk for Pathologic Fracture
Pages 275-295
Liberini, Virginia (et al.)
Differentiated Thyroid Cancer and Brain Metastases
Pages 297-302
Sherman, Steven I.
RAI-Refractory, Advanced Differentiated Thyroid Cancer Receiving Kinase Inhibitor Treatment: Checking for Drug-Drug Interactions
Pages 303-308
Sherman, Steven I.
Management of Postoperative Hypercalcitoninemia in Medullary Thyroid Carcinoma
Pages 311-318
Ball, Douglas W.
Tumor Related- and Non-tumor-Related Diarrhea in a Medullary Thyroid Cancer Patient
Pages 319-325
Falcone, Rosa (et al.)
Clinical Management of a Patient with a Locally Recurrent Medullary Thyroid Cancer and Asymptomatic Slowly Progressing Distant Metastases
Pages 327-335
Cappagli, Virginia (et al.)
A Patient with an Advanced Medullary Thyroid Cancer and Progressive, Symptomatic Distant Metastases: When to Start Systemic Therapy
Pages 337-346
Giani, Carlotta (et al.)
Medical Treatment Decision-Making for Advanced Medullary Thyroid Cancer
Pages 347-359
Dadu, Ramona (et al.)
Screening Leading to Diagnosis of C cell Hyperplasia
Pages 361-365
Costante, Giuseppe
Increased Basal Calcitonin in Nodular Goiter: Is It Micromedullary Thyroid Cancer?
Pages 367-373
Machens, Andreas (et al.)
Timing and Extent of Surgery for a Pediatric Patient with Hereditary MTC and Positive Screening for the p.S891A RET Mutation
Pages 375-380
Dralle, Henning (et al.)
Anaplastic Thyroid Cancer: Surgery or Not in Locally Advanced Disease
Pages 383-390
Chintakuntlawar, Ashish V. (et al.)
A Patient with BRAFV600E-Mutated Anaplastic Thyroid Cancer with Metastatic Disease
Pages 391-396
Cabanillas, Maria E. (et al.)
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