Informazioni
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Hemoglobin: Structure, Synthesis and Oxygen Transport
Pages 1-22
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Sickle Cell Anemia
From Basic Science to Clinical Practice
Costa, Conran
Editore
Springer
Anno
2016
Pagine
435
ISBN
9783319067124
120,00 €
Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
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Sickle Cell Anemia: History and Epidemiology
Pages 23-47
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Overview of Sickle Cell Anemia Pathophysiology
Pages 49-73
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Red Blood Cells and the Vaso-Occlusive Process
Pages 75-90
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Leukocytes in the Vaso-Occlusive Process
Pages 91-107
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Hypercoagulability and Sickle Cell Disease
Pages 109-127
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Cardiovascular Adaptations to Anemia and the Vascular Endothelium in Sickle Cell Disease Pathophysiology
Pages 129-175
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Inflammation and Sickle Cell Anemia
Pages 177-211
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Clinical Manifestations of Sickle Cell Anemia: Infants and Children
Pages 213-229
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Treatment of Childhood Sickle Cell Disease
Pages 231-267
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Priapism in Sickle Cell Disease: New Aspects of Pathophysiology
Pages 269-283
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Clinical Manifestations and Treatment of Adult Sickle Cell Disease
Pages 285-318
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Hemoglobin Sβ Thalassemia, SC Disease and SD Disease: Clinical and Laboratorial Aspects
Pages 319-337
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Sickle Cell Disease in Africa and the Arabian Peninsula: Current Management and Challenges
Pages 339-370
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Genetic Factors Modifying Sickle Cell Disease Severity
Pages 371-397
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Future Perspectives for the Treatment of Sickle Cell Anemia
Pages 399-429
