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Quality in Laboratory Hemostasis and Thrombosis, 2nd Edition
Kitchen, Olson, Preston
96,00 €
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Quality in Laboratory Hemostasis and Thrombosis

Second Edition

Edited by

Steve Kitchen, Clinical Scientist, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA

F. Eric Preston, Emeritus Professsor of Haematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK

The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Rapid changes in the number and complexity of tests in this discipline have presented challenges for laboratories, as they develop quality programs for the oversight of this testing.

Quality in Laboratory Hemostasis and Thrombosis has been completely revised and updated to reflect the changing process of managing quality. The second edition provides information on all aspects of testing, from pre-analytic to analytic and result reporting, in addition to external quality assurance. Chapters throughout the book include the development of global guidelines for methods, as well as the preparation of international standard plasmas and reagents.

Designed to capture the elements of quality at all levels of the practice of laboratory hemostasis and thrombosis, this book will guide the reader through the development of a quality program to support all activities in the hemostasis laboratory, both simple and complex.

  • Table of Contents

Contributors, vii

Foreword, x

Preface, xii

Steve Kitchen, John D. Olson, & F. Eric Preston

Part 1: General Quality Program

1 General quality planning in the hemostasis laboratory, 3
John D. Olson

2 Hemostasis test validation, performance, and reference intervals: international recommendations and guidelines, 12
Richard A. Marlar

3 Causes of errors in medical laboratories, 22
Giuseppe Lippi & Emmanuel J. Favaloro

4 International standards in hemostasis, 32
Trevor W. Barrowcliffe & Anthony R. Hubbard

5 Sample integrity and preanalytical variables, 45
Dorothy (Adcock) Funk

6 Internal quality control in the hemostasis laboratory, 57
Steve Kitchen, F. Eric Preston, & John D. Olson

7 External quality assessment in hemostasis: its importance and significance, 65
F. Eric Preston, Steve Kitchen, & Alok Srivastava

8 The unique challenges of hemostatic testing in children, 77
M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, & Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

9 Initial evaluation of hemostasis: reagent and method selection, 95
Wayne L. Chandler

10 Assay of factor VIII and other clotting factors, 105
Steve Kitchen & F. Eric Preston

11 Application of molecular genetics to the investigation of inherited bleeding disorders, 115
Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen

12 Detecting and quantifying acquired functional inhibitors in hemostasis, 124
Bert Verbruggen, Myriam Dardikh, & Britta Laros-van Gorkom

13 Standardization of d-dimer testing, 136
Guido Reber & Philippe de Moerloose

14 Point-of-care testing in hemostasis, 147
Chris Gardiner, Dianne Kitchen, Samuel Machin, & Ian Mackie

Part 3: Quality in Testing for Platelet Function and von Willebrand Disease

15 Diagnostic assessment of platelet function, 159
Paquita Nurden, Alan Nurden, & Martine Jandrot-Perrus

16 Laboratory evaluation of heparin-induced thrombocytopenia, 174
Theodore (Ted) E. Warkentin & Jane C. Moore

17 Laboratory evaluation of von Willebrand disease: phenotypic analysis, 192
Emmanuel J. Favaloro

18 Laboratory analysis of von Willebrand disease: molecular analysis, 204
Anne C. Goodeve & Ian R. Peake

Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation

19 Quality issues in heritable thrombophilia testing, 219
Isobel D. Walker & Ian Jennings

20 Evaluation of antiphospholipid antibodies, 233
Michael Greaves

21 Monitoring heparin therapy, 244
Marilyn Johnston

22 Monitoring oral anticoagulant therapy with vitamin K antagonists, 253
Armando Tripodi

23 Monitoring new anticoagulants, 264
Elaine Gray & Trevor W. Barrowcliffe

Index, 273



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