Neuro-oncologic (brain and spine) cancers account for 19,000 new cases and 13,000 deaths per year. The early and proper diagnosis of these virulent cancers is critical to patient outcomes and diagnosis and treatment strategies are continually evolving. The multidisciplinary team that manages these patients involves medical and radiation oncology, neurosurgery, neuroimaging, nurses and therapists.
Principles and Practices of Neuro-Oncology establishes a new gold standard in care through a comprehensive, multidisciplinary text covering all aspects of neuro-oncology. Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric cancers. Expert contributors from multiple disciplines provide detailed and in-depth discussions of the entire field of neuro-oncology including histopathologic harmonization, neurosurgical techniques, quality of life and cognitive functions, and therapeutic changes in terms of combined modality treatments, advanced radiation techniques, the advent of new drugs, especially targeted agents, and the tantalizing early promise of personalized therapeutic approaches.
With contributions from over 180 authors, numerous diagrams, illustrations and tables, and a 48 page color section, Principles and Practice of Neuro-Oncology reflects the breadth and depth of this multi-faceted specialty.
Contents: Part One EPIDEMIOLOGY: Gliomas: 1. Epidemiology and Etiology of Glioma: An Overview; 2. Descriptive Epidemiology of Glioma; 3. Familial Factors and Inherited Susceptibility to Glioma; 4. Chemical Exposures Mediated Through Occupation, Environment and Lifestyle, and Brain Tumor Risk; 5. Exposure to Ionizing Radiation and Glioma Risk; 6. Radiofrequency Fields and Glioma Risk; 7. Allergies and Glioma Risk; 8. Glioma Survival and Prognosis; Childhood Brain Tumors: 9. Epidemiology of Childhood Brain Tumors; 10. Meningioma Genetics; Part Two MOLECULAR BIOLOGY: 11. Molecular Neuro-oncology: Why is it Essential?; 12. Brain Tumor Initiating Cells: History, New Advances, Therapeutic Promises, and Pitfalls; 13. Molecular Pathogenesis of Glioma: Overview and Therapeutic Implications; 14. Molecular Heterogeneity and Tumor Microenvironment; 15. Molecular Regulators of Glioma Invasion; 16. Molecular Basis of Glioma Neovascularization and Its Therapeutic Applications; 17. Mouse Models of Central Nervous System Tumors: Part 1 Transgenic Mouse Models of Central Nervous System Tumors; Mouse Models of Central Nervous System Tumors: Part 2 Transplantation Mouse Models of Central Nervous System Tumors; 18. Pathology and Genetics of Meningiomas; 19. Histopathology and Molecular Pathogenesis of Schwannomas; 20. Histopathology and Molecular Pathogenesis of Pituitary Adenomas; 21. Histopathology and Molecular Pathogenesis of Neurofibromas and Malignant Peripheral Nerve Sheath Tumors; Pediatric Brain Tumors: 22. The ëCell of Originí For Common Pediatric Brain Tumors; 23. Histopathological Features of Common Pediatric Brain Tumors; 24. Molecular Genetics of Medulloblastoma and High Grade Astrocytomas in Children; 25. Molecular Pathogenesis of Neuroblastomas; 26. Pediatric Brain Tumor Syndromes and Murine Models; 27. Predisposition Syndromes: Neurofibromatosis 1, Neurofibromatosis 2, Tuberous Sclerosis Complex; Part Three: CLINICAL PRESENTATION AND SUPPORTIVE CARE: 28. Presentation and Clinical Features of Supratentorial Gliomas in Adults; 29. Presentation and Clinical Features of Brain Metastases; 30. Presentation and Clinical Features of Medulloblastoma; 31. Presentation and Clinical Features of Pediatric Gliomas; 32. Presentation and Clinical Features of Brainstem Tumors; 33. Presentation and Clinical Features of Tumors of the Skull Base and Cranial Nerves; 34. Presentation and Clinical Features of Tumors of the Pituitary and Sellar Region; 35. Presentation and Clinical Features of Spinal Cord Tumors; Supportive Care and Quality of Life: 36. Supportive Care in Neuro-Oncology; 37. Ethical Issues in Neuro-Oncology; 38. Role of Support Groups and Caregivers in Neuro-Oncology; 39. Neuro-cognitive Function and Quality of Life; 40. Neuropsychological Sequelae of Adult Brain Tumors; 41. Neuropsychological Sequelae Associated with Pediatric Brain Tumors: What We've Learned Over the Past Forty Years; 42. Rehabilitation of Central Nervous System Tumors; 43. Palliative Care in Neuro-Oncology; Imaging: 44. Imaging of Brain Tumors; Part Four: NEUROANATOMY AND NEUROSURGERY: Anatomy: 45. Functional Neuroanatomy; 46. Skull Base Anatomy; Technology and Specialized Techniques: 47. Surgical Navigation; 48. Stereotactic Brain Biopsy; 49. Intraoperative Anatomical Imaging; 50. Intraoperative Molecular Imaging; 51. Intraoperative Functional Mapping; 52. Endoscopy; Procedures: 53. Transsphenioidal; 54. Spinal Neoplasms; 55. Spinal Cord Tumors; 56. Low Grade Gliomas; 57. Pineal Gland Tumors; 58. Intraventricular Tumors; 59. Insular Tumors; 60. Pediatric Tumor Surgery; 61. Brachial Plexus Tumor; Part Five: MEDICAL ONCOLOGY: 62. General Principles; 63. Medical Management of Supratentorial Gliomas in Adults; 64. Medical Management for Pediatric Gliomas; 65. Medical Management of Primitive Neuroectodermal Tumors; 66. Intracranial Meningiomas; 67. Medical Management for Brainstem Tumors; 68. Chemotherapy for Tumors of the Skull Base and Cranial Nerves; 69. Tumors of the Pituitary and Sellar Region; 70. Medical Treatment of Spinal Cord Tumors; 71. Brain Metastases and Leptomeningeal Disease; 72. Primary Central Nervous System Lymphoma; 73. Medical Treatment Primary Central Nervous System Germ Cell Tumors; 74. Medical Management for Choroid Plexus Tumors; Targeted Therapies: 75. General Principles of Targeted Therapies; 76. General Principles of Angiogenesis; 77. Inhibitors of Signal Transduction Pathways in Malignant Glioma Therapy; 78. Biologics; 79. Other Therapies; 80. Alternative Therapies; Part Six: RADIATION THERAPY: 81. Introduction to Radiation Therapy; Supratentorial Gliomas: 82. Radiation for Glioblastoma; 83. Anaplastic Glioma; 84. Low-Grade Glioma Radiation Therapy; 85. Ganglioglioma; 86. Optic Pathway Glioma; 87. The Current Role for Radiation Therapy in Pediatric Grade II-IV (Non-JPA) Gliomas; 88. Medulloblastoma and Primitive Neuroectodermal Tumors; 89. Adult and Pediatric Pilocytic Astrocytoma; Posterior Fossa Tumors: 90. Ependymoma (Intracranial); 91. Vestibular Schwannoma; 92. Hemangioblastoma and Hemangiopericytoma; 93. Radiation Therapy for Intracranial Meningiomas; 94. Adult and Pediatric Brainstem Glioma; 95. Tumors of the Skull Base; Tumors of the Pituitary and Stellar Region: 96. Pituitary Tumors and Craniopharyngioma; 97. Primary Central Nervous System Germ Cell Tumors, Pineal Tumors, and Other Tumors of the Pineal and Stellar Regions; 98. Primary Central Nervous System Lymphoma; Others: 99. Neurocytoma; 100. Radiation Therapy of Primary Spinal Cord Tumors; 101. Metastatic Disease