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Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Leptin
Regulation and Clinical Applications
Dagogo-Jack
Editore
Springer
Anno
2015
Pagine
287
ISBN
9783319099149
140,00 €
- Emphasizes metabolic pathophysiology and clinical applications of leptin in humans
- Presents therapeutic trials of recombinant leptin replacement in humans for a variety of disorders
- Considers the future direction of human leptin research and treatment possibilities
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone.
Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.
Table of Contents
1 Discovery of Leptin and Elucidation
of Leptin Gene Expression ........................................................... 1
Margherita Maffei
2 Leptin Receptors and Mechanism of Action .............................. 15
Julie Dam, Ralf Jockers, Michèle Guerre-Millo,
and Karine Clément
3 Leptin Interaction with Brain Orexigenic
and Anorexigenic Pathways ......................................................... 25
Denis G. Baskin
4 Measurement of Circulating Leptin
and Soluble Leptin Receptors ...................................................... 39
Robert V. Considine
5 Physiological and Hormonal Factors that Influence
Leptin Production ......................................................................... 45
Sam Dagogo-Jack
6 Leptin, Obesity, and Leptin Resistance....................................... 67
Heike Münzberg and Steven B. Heymsfi eld
7 Leptin and Intermediary Metabolism:
Focus on Glucoregulation and Lipids ......................................... 79
Rachel C. Morgan and Robert V. Considine
8 Pathogenesis of Hepatic Steatosis and Fibrosis:
Role of Leptin ................................................................................ 89
Faidon Magkos, Elisa Fabbrini, and Samuel Klein
9 Leptin in Acute Stress ................................................................... 103
Stephen N. Davis, Elizabeth M. Lamos, Hillary Loper,
and Lisa M. Younk
10 Leptin and the Kidney .................................................................. 117
Richa Pandey, Anubha Mutneja, Daniel W. Coyne,
and Sam Dagogo-Jack
11 Leptin, Immune Function, and Inflammation ........................... 131
Giuseppe Matarese, Claudio Procaccini, Valentina Pucino,
and Christos Mantzoros
12 Leptin and Bone ............................................................................ 145
Patricia Ducy and Stavroula Kousteni
13 Leptin, Cell Cycle, and Cancer .................................................... 163
Olorunseun O. Ogunwobi
14 Leptin, the Autonomic Nervous System,
and Hypertension .......................................................................... 175
Alexandre A. da Silva, Jussara M. do Carmo, Zhen Wang,
and John E. Hall
15 Dynamic Leptin Secretion in Obesity and Diabetes .................. 189
Sam Dagogo-Jack
16 Leptin Therapy in People with Congenital
Leptin Deficiency .......................................................................... 203
Gilberto Paz-Filho and Julio Licinio
17 Leptin Therapy in People with a Normal Leptin Gene ............. 215
Steven B. Heymsfi eld and Heike Münzberg
18 Leptin Therapy in Patients with Lipodystrophy
and Syndromic Insulin Resistance .............................................. 225
Rebecca J. Brown and Phillip Gorden
19 Leptin Therapy in Women with Hypothalamic
Amenorrhea ................................................................................... 237
Sharon H. Chou and Christos Mantzoros
20 Leptin Therapy as a Substitute for Insulin Replacement
in Experimental Models of Diabetes: Clinical Implications
in Humans ...................................................................................... 255
Satya Paul Kalra
21 Novel Combinatorial Therapies Involving Leptin:
Opportunities for Mechanistic Advances
and Therapeutic Translation in Human Diseases ...................... 267
Timo D. Müller, Christoffer Clemmensen, Brian Finan,
Richard D. DiMarchi, and Matthias H. Tschöp
Index ...................................................................................................... 281
