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A highly disabling infectious disease in developing countries, leprosy, or Hansen’s disease, is caused by Mycobacterium leprae, and is still very relevant for the human community due to its transmissible nature, variable presentation and composite clinical picture. Early identification of leprosy and Buruli ulcer (also caused by a Mycobacterium, M. ulcerans) is critical to prevent spreading and patient disability and to establish appropriate therapy.
This richly illustrated, completely revised second edition of Leprosy and Buruli Ulcer describes the characteristic signs of both these diseases, and contents include abnormalities of the skin, nerves, eyes, hands, feet, testes and bone. It also presents the latest diagnostic tools to identify and quantify organ damage to enable readers to recognize and treat this composite systemic disorder, which can represent a true medical emergency if affecting eyes, nerves, and kidneys. Further, it includes additional chapters on leprosy in childhood, prophylaxis and vaccines. For both leprosy and Buruli ulcer, this handy guide helps practitioners and nursing personnel to spot the different clinical manifestations, make a prompt diagnosis and apply effective treatment of both these diseases.
Pages i-xvi
Front Matter
Pages 1-1
History and Phylogeography of Leprosy
Pages 3-12
Microbiology of Mycobacterium leprae
Pages 13-17
Pages 19-29
Host Response to Mycobacterium leprae
Pages 31-44
Pages 45-48
Pages 49-53
Front Matter
Pages 55-55
Pages 57-59
Laboratory Investigations in Leprosy
Pages 61-70
Front Matter
Pages 71-71
Physical Examination in Leprosy: Skin
Pages 73-82
Pages 83-120
Pages 121-124
Histopathology of the Skin in Leprosy
Pages 125-146
Differential Diagnosis of Leprosy: Skin
Pages 147-160
Front Matter
Pages 161-161
Pages 163-176
Pages 177-193
Pages 195-199
Chronic Neuropathic Pain in Leprosy
Pages 201-205
Electrodiagnostic Studies in Leprosy
Pages 207-211
Pages 213-222
Differential Diagnosis of Leprosy: Nerves
Pages 223-230
Front Matter
Pages 231-231
Pages 233-258
Pages 259-263
Front Matter
Pages 265-265
Pages 267-274
Otolaryngological Manifestations of Leprosy
Pages 275-280
Other Organs Involved in Leprosy
Pages 281-287
Front Matter
Pages 289-289
Pages 291-299
Pages 301-309
Treatment and Prophylaxis of Leprosy
Pages 311-325
Pages 327-329
Pages 331-336
Prevention of Disability and Ulcer Care in Leprosy
Pages 337-350
Surgical and Social Rehabilitation in Leprosy
Pages 351-357
Front Matter
Pages 359-359
Pages 361-370
Pages 371-380
Leprosy and HIV/AIDS Co-infection
Pages 381-387
Pages 389-402
Pages 403-413
Pages 415-417
Front Matter
Pages 419-419
History and Geographic Distribution of Buruli Ulcer
Pages 421-430
Microbiology of Mycobacterium Ulcerans
Pages 431-440
Front Matter
Pages 441-441
Laboratory Investigations in Buruli Ulcer
Pages 443-454
Clinical Features of Buruli Ulcer
Pages 455-463
Differential Diagnosis of Buruli Ulcer
Pages 465-487
Front Matter
Pages 489-489
Diagnostic Work-up of Buruli Ulcer
Pages 491-508
Pages 509-527
Rehabilitation in Buruli Ulcer
Pages 529-538
Front Matter
Pages 539-539
Pages 541-550
Pages 551-559
Pages 561-570
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