Front Matter
    Pages i-xii
 
    Frailty and Related Concepts: An Overview
        Front Matter
        Pages 1-1

        The Frailty Phenotype
            Jorge G. Ruiz, Sara Espinoza
        Pages 3-9
        Deficit Accumulation
            Samuel D. Searle, Kenneth Rockwood
        Pages 11-14
        Prevalence, Incidence, and Risk Factors of Frailty
            Gotaro Kojima, Reijiro Aoyama, Steve Iliffe
        Pages 15-18
        Integration: A Unified Frailty Framework
            Domenico Azzolino, Matteo Cesari
        Pages 19-22
        Intrinsic Capacity
            Catherine Takeda, Philippe De Souto Barreto, Bruno Vellas
        Pages 23-29
        Transitions, Trajectories, and Reversibility
            Ariela Orkaby, Rachel E. Ward
        Pages 31-38
        Sarcopenia and Frailty: A Common Thread Across Multiple Comorbidities
            K. Prokopidis, J. Hargreaves, T. Ispoglou
        Pages 39-43
        Complications of Frailty
            Luis Miguel Gutiérrez Robledo, Mario Ulises Pérez Zepeda
        Pages 45-49
        Sex Differences and Frailty
            Myles W. O’Brien, Judith Godin
        Pages 51-54
    Mechanisms: Pathogenesis and Research
        Front Matter
        Pages 55-55
      
        Inflammaging and Immunosenescence
            Tamàs Fülöp, G. Pawelec, A. A. Cohen, V. Legault, K. Hirokawa, A. Larbi et al.
        Pages 57-71
        Implications of the Exposome for Frailty
            Paulo H. M. Chaves, Marcia H. Varella
        Pages 73-79
        Preclinical Models of Frailty
            Manish Mishra, Susan E. Howlett
        Pages 81-89
        Biomarkers of Frailty
            Mariam El Assar, Isabel Rodriguez-Sanchez, Alejandro Álvarez-Bustos, Leocadio Rodríguez-Mañas
        Pages 91-102
        Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View
            Anna Picca, Marta Gonzalez-Freire, Stephen D. Anton, Emanuele Marzetti, Christiaan Leeuwenburgh
        Pages 103-107
        Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms
            Peter J. Larson, Wei Zhou, Julie Robison, George A. Kuchel, Julia Oh
        Pages 109-117
    Assessment
        Front Matter
        Pages 119-119

        Clinical Frailty Scale
            Kenneth Rockwood, Olga Theou
        Pages 121-123

    Frailty Measure Development, Selection, and Implications
        Karen Bandeen-Roche
    Pages 125-129
    Pictorial Fit-Frail Scale
        Olga Theou, Kenneth Rockwood
    Pages 131-135
    Frailty Assessment: The FRAIL Scale
        Angela M. Sanford, John E. Morley
    Pages 137-141
    Edmonton Frail Scale
        Darryl B. Rolfson
    Pages 143-144
    The Tilburg Frailty Indicator (TFI)
        Robbert J. J. Gobbens
    Pages 145-149
    The Study of Osteoporotic Fractures (SOF) Frailty Index
        Kristine E. Ensrud
    Pages 151-155
    Physical Assessments Instruments
        M. Aubertin-Leheudre, F. Buckinx
    Pages 157-166
    Technology-Based Assessments of Frailty
        Megan Huisingh-Scheetz, Nabiel Mir, M. Lucia Madariaga, Daniel Rubin
    Pages 167-172
    Frailty Tools Using Health Care Databases
        Stephanie Denise M. Sison, Dae Hyun Kim
    Pages 173-178

Management: Treatment and Prevention

    Front Matter
    Pages 179-179

    Comprehensive Geriatric Assessment CGA
        Wakana Teranaka, Simon Conroy
    Pages 181-185
    Exercise Strategies for Improving Health Outcomes in Older Adults with Comorbidities: The Role of Vivifrail Tailored-Multicomponent Training
        Mikel Izquierdo
    Pages 187-200
    Nutritional Aspects of Frailty in Older Adults: Undernutrition, Nutrients Consumption, and Diet Patterns
        Hélio José Coelho-Junior, Emanuele Marzetti
    Pages 201-209
    Deprescribing
        Sarah N. Hilmer, Nashwa Masnoon
    Pages 211-215
    Geroscience-Based Interventions
        Oh Sung Kwon, Sara Espinoza
    Pages 217-222
    Integrated Care for Frailty
        Anne Hendry, Ronan O’Caoimh, Mohamed A. Salem, Ana Carriazo, Regina Roller-Wirnsberger
    Pages 223-228

Settings of Care

    Front Matter
    Pages 229-229

    Frailty in Primary Care: Interventions and Opportunities
        John Travers, Marie Therese Cooney, Roman Romero-Ortuno
    Pages 231-237
    Frailty in Acute Care Settings
        Natasha Melo Resendes
    Pages 239-248
    Frailty in Nursing Homes
        Renuka Visvanathan
    Pages 249-253

    Rehabilitation
        Margaret Danilovich
    Pages 255-258
    Palliative Care
        Daniel Stow, Sarah Combes, Felicity Dewhurst
    Pages 259-265
    Frailty in Home Care
        Carmen Castillo Gallego
    Pages 267-271
    A Community-Based Model for Detecting and Managing Frailty
        Jean Woo, Ruby Yu, Anson Kai-Chun Chau
    Pages 273-278

Other Conditions

    Front Matter
    Pages 279-279

    Bidirectional Relationships Between COVID-19 and Frailty in Older Adults
        Chia-Ling Kuo, Patrick P. Coll, George A. Kuchel
    Pages 281-285
    Frailty and Cancer
        Marco Ruiz, Natasha Melo Resendes, Jannelle Vicens
    Pages 287-297
    Frailty and Cardiovascular Disease
        Deirdre E. O’Neill, Daniel E. Forman
    Pages 299-308
    Frailty in Older People with Diabetes Mellitus
        Alan J. Sinclair, A. H. Abdelhafiz
    Pages 309-324
    Frailty and Cognition. Fellow Travelers or Partners in Crime?
        Manuel Montero-Odasso, Frederico Pieruccini-Faria, Qu Tian, Joe Verghese
    Pages 325-332
    Frailty and Orthogeriatrics: Enhancing Care for Fragility Fractures
        Mauricio Vazquez-Guajardo, Gustavo Duque
    Pages 333-343
    Frailty in Older Adults with Obesity and the Effect of Lifestyle Interventions
        Georgia Colleluori, Dennis T. Villareal
    Pages 345-349
    Vaccines, Vaccine-Preventable Diseases, and Frailty
        Henrique Pott, Melissa K. Andrew
    Pages 351-358
    Oral Health and Frailty
        Christie-Michele Hogue, Roberto Carlos Castrejón-Pérez
    Pages 359-368
    Perioperative, Surgical, and Procedural Care for Older Adults with Frailty
        Daniel I. McIsaac, Sylvie D. Aucoin
    Pages 369-375
    Delirium
        Giuseppe Bellelli, Maria Cristina Ferrara, Alessandro Morandi
    Pages 377-385

Social and Other Issues

    Front Matter
    Pages 387-387

    Social Determinants of Physical Frailty
        Brian Buta, Erica Twardzik, Laura Samuel, Thomas Cudjoe, Anthony L. Teano, Jackie Langdon et al.
    Pages 389-401
    Educating and Training the Workforce
        Iriana S. Hammel, Elizabeth N. Chapman
    Pages 403-409
    Frailty in Low- and Middle-Income Countries
        Tania Tello, Ximena Guevara, Paola Casas
    Pages 411-418

    Ethical and Policy Aspects of Frailty
        John Muscedere
    Pages 419-423

Back Matter
Pages 425-430