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Advances in cancer therapy and transplantation are increasing the numbers of immunocompromised patients throughout the world. This comprehensive review presents state-of-the-art diagnostics for infectious complications in the immunocompromised patients. Providing complementary views of often complex diagnostic challenges, the new edition presents topics such as host biology and antineoplastic and transplantation techniques; the basis of immunosuppressive conditions ranging from diabetes to age-related immunosuppression; the approach, interpretation, and limitations of the laboratory diagnosis of infections caused by a wide range of etiologic agents; laboratory diagnosis of infections of organ systems, such as respiratory tract, gastrointestinal tract, and central nervous system; and, diagnostic aspects of prosthetic devices and catheters, healthcare-acquired infections, and morphologic considerations (anatomic pathology). New sections discuss tissue pathology, HIV, hepatitis viruses, papilloma and polyoma viruses, and aerobic and anaerobic bacteriology. This book will inform laboratory medicine specialists, pathologists, technologists, students, and clinical care professionals who are involved or interested in the care of patients who are immunocompromised.
	Strategies for providing optimal care to this high-risk patient group.
	The immunocompromised patient population is increasing throughout the world. Major advances in transplantation techniques have expanded access to lifesaving therapies and improved outcomes in these high-risk populations. An understanding of the biology of these infections, host conditions, and the limitations of technologies used to detect and quantify such pathogens is critical to optimal care.
	This new edition of Diagnostic Microbiology of the Immunocompromised Host covers all aspects of state-of-the-art diagnostics for infectious complications in the immunocompromised patient. Editors Randall Hayden, Karen Carroll, Yi-Wei Tang and Donna Wolk, assembled the contributions of a team of preeminent authors to discuss a broad range of topics, including
	• relevant aspects of host biology, antineoplastic, and transplantation techniques and the basis of immunosuppressive conditions ranging from diabetes to age-related immunosuppression
	• approaches, interpretations, and limitations of laboratory diagnosis of infections by a wide range of specific etiologic agents 
	• laboratory diagnosis of infections of specific organ systems, such as respiratory tract infections, gastrointestinal tract infections, and central nervous system infections
	• special topics such as prosthetic devices and catheters, healthcare acquired infections, and morphologic considerations (anatomic pathology) 
	• future diagnostic technologies and their potential impact on the field 
	Diagnostic Microbiology of the Immunocompromised Host is a resource for laboratory medicine specialists, pathologists, technologists, students, and clinical care professionals who are involved or interested in the care of the immunocompromised host.
Contents
	Contributors
	Preface
	Foreword
I. OVERVIEW OF INFECTIONS IN THE IMMUNOCOMPROMISED HOST
	1. Overview of Infections in the Immunocompromised Host
	Lesia K. Dropulic and Howard M. Lederman
	II. LABORATORY DIAGNOSIS: APPROACHES, INTERPRETATIONS, AND LIMITATIONS
	INFECTIONS BY SPECIFIC ETIOLOGIC AGENTS
	2. Human Immunodeficiency Virus
	Wendy S. Armstrong, Jeannette Guarner, Colleen S. Kraft, and Angela M. Caliendo
	3. Chronic Hepatitis B, C, and D
	Bryan R. Cobb and Alexandra Valsamakis
	4. Cytomegalovirus
	M. Veronica Dioverti and Raymund R. Razonable
	5. Epstein-Barr Virus
	Andrew Nowalk and Michael Green
	6. Herpes Simplex Virus and Varicella-Zoster Virus
	Myron J. Levin, Adriana Weinberg, and D. Scott Schmid
	7. Human Herpesviruses 6A, 6B and 7
	Henri Agut, Pascale Bonnafous, and Agnès Gautheret-Dejean
	8. Human Papillomavirus
	Eileen M. Burd and Christina L. Dean
	9. Polyomaviruses
	Linda Cook
	10. Adenovirus
	Michael G. Ison and Randall T. Hayden
	11. Respiratory RNA Viruses
	Richard L. Hodinka
	12. Enteroviruses and Parechoviruses
	James J. Dunn
	13. Parvovirus B19
	Marie Louise Landry
	14. Filamentous Fungi
	Margaret V. Powers-Fletcher, Brian A. Kendall, Allen T. Griffin, and Kimberly E. Hanson
	15. Yeasts
	Sean X. Zhang and Nathan P. Wiederhold
	16. Mycobacteria
	Patricia J. Simner, Gail L. Woods, and Nancy L. Wengenack
	17. Aerobic Actinomycetes of Clinical Significance
	A. Brian Mochon, Den Sussland, and Michael A. Saubolle
	18. Parasites
	Elitza S. Theel and Bobbi S. Pritt
	19. Selected Topics in Aerobic Bacteriology
	Geraldine Hall and Karen C. Carroll
	20. Selected Topics in Anaerobic Bacteriology
	Deirdre L. Church
	III. LABORATORY DIAGNOSIS: APPROACHES, INTERPRETATIONS AND LIMITATIONS
	INFECTIONS OF SPECIFIC ORGAN SYSTEMS
	21. Lower Respiratory Tract Infections
	Karen C. Carroll and La’Tonzia L. Adams
	22. Genitourinary Tract Infections
	Odaliz Abreu Lanfranco and George J. Alangaden
	23. Gastrointestinal Infections
	Kevin Alby and Irving Nachamkin
	24. Central Nervous System Infections
	Andrea J. Zimmer, Victoria E. Burke, and Karen C. Bloch
	25. Bloodstream Infections
	Donna M. Wolk, Raquel M. Martinez, and Diana R. Hernandez
	26. Skin and Soft Tissue Infections
	Anne Spichler Moffarah, Mayar Al Mohajer, Bonnie L. Hurwitz, and David G. Armstrong
IV. SPECIAL TOPICS
	27. Prosthetic Device Infections
	Raquel M. Martinez, Thomas R. Bowen, and Michael A. Foltzer
	28. Hospital-Associated Infections
	Esther Babady
	29. Surgical Pathologic Diagnosis
	Mary K. Klassen-Fischer and Ronald C. Neafie
Index
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