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Introduction on Cancer Immunology and Immunotherapy
Pages 1-9
This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field.
In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.
Introduction on Cancer Immunology and Immunotherapy
Pages 1-9
Role of Innate Immunity in Cancers and Antitumor Response
Pages 11-28
Tumor-Associated Myeloid Cells in Cancer Progression
Pages 29-46
B-Cells in Cancer Immunology: For or Against Cancer Growth?
Pages 47-62
The Roles of CD4+ T-Cells in Tumor Immunity
Pages 63-90
Regulatory T-Cells and Th17 Cells in Tumor Microenvironment
Pages 91-106
Pages 107-116
The Role of Exhaustion in Tumor-Induced T-Cell Dysfunction in Cancer
Pages 117-132
The Role of NK Cells in Cancer
Pages 133-146
Role of Plasmacytoid Dendritic Cells in Cancer
Pages 147-169
The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis
Pages 171-188
MHC Class I Molecules and Cancer Progression: Lessons Learned from Preclinical Mouse Models
Pages 189-204
Pages 205-233
Role of Chemokines and Chemokine Receptors in Cancer
Pages 235-262
Role of the Inflammasome in Cancer
Pages 263-289
Cancer Immunoediting: Immunosurveillance, Immune Equilibrium, and Immune Escape
Pages 291-305
Pages 307-353
Endoplasmic Reticulum Stress and Autophagy in Cancer
Pages 355-402
Prognostic Value of Innate and Adaptive Immunity in Cancers
Pages 403-415
Immunogenetics of Cancer
Pages 417-478
Epigenetics and MicroRNAs in Cancer
Pages 479-489
The Role of DNA Methylation in Cancer
Pages 491-511
Immunosenescence, Oxidative Stress, and Cancers
Pages 513-531
Nutrition, Immunity, and Cancers
Pages 533-544
Inborn Errors of Immunity and Cancers
Pages 545-583
Allergies and Cancers
Pages 585-598
Envisioning the Application of Systems Biology in Cancer Immunology
Pages 599-624
Principles of Immunological Diagnostic Tests for Cancers
Pages 625-643
Immunohistochemistry of Cancers
Pages 645-709
Fluorescent In Situ Hybridization: Methods and Application in Cancer Diagnosis
Pages 711-728
Cancer Molecular and Functional Imaging
Pages 729-738
Cancer Imaging with Radiolabeled Monoclonal Antibodies
Pages 739-760
Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future
Pages 761-783
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