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This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomics of breast cancer in high-risk women, computer-aided detection/diagnosis and machine learning systems applied to breast MRI, and psycho-oncology issues. Alternatives to breast MRI screening such as pharmaco-prevention and prophylactic mastectomy are also discussed, taking into account the public debate on the “Angelina Jolie” effect. The high breast cancer risk model is proposed as a paradigm for personalized medicine. This book will be of interest to radiologists, surgeons, oncologists and to all professionals devoted to female healthcare.
From NMR to Clinical Breast MRI
Pages 1-9
Sardanelli, Francesco (et al.)
The Mantra about Low Specificity of Breast MRI
Pages 11-21
Baltzer, Pascal A. T. (et al.)
Hereditary Breast Cancer: BRCA and Other Susceptibility Genes
Pages 23-41
Azzollini, Jacopo (et al.)
MRI Protocols for Breast Cancer Screening
Pages 43-61
Mann, Ritse M. (et al.)
Gadolinium-Based Contrast Agents for Breast MRI and Uncertainties About Brain Gadolinium Retention
Pages 63-82
Sardanelli, Francesco (et al.)
Applying the MRI BI-RADS in a High-Risk Population
Pages 83-95
Clauser, Paola (et al.)
CAD and Machine Learning for Breast MRI
Pages 97-111
Martel, Anne L.
Radiogenomics and Phenotype Presentation of Breast Cancer with a Special Focus on High-Risk Women
Pages 113-130
Pinker, Katja (et al.)
Primary Studies on Breast MRI Screening of High-Risk Women
Pages 131-151
Sardanelli, Francesco (et al.)
Genetic/Familial High-Risk Screening: MRI Alone?
Pages 153-166
Marino, Maria A. (et al.)
Systematic Reviews, Meta-Analyses, and Cost-Effective Analyses on Breast MRI Screening of High-Risk Women
Pages 167-187
Sardanelli, Francesco (et al.)
Radioprotection Issues for Women with Hereditary Predisposition for Breast Cancer
Pages 189-200
Colin, Catherine (et al.)
Impact of MRI Screening on High-Risk Patient Outcome
Pages 201-221
Podo, Franca (et al.)
The Special Case of Previous Chest Radiation Therapy
Pages 223-234
Trimboli, Rubina M. (et al.)
Electronic Data Capture Systems for Breast Cancer Research
Pages 235-250
Leo, Giovanni (et al.)
Guidelines and Recommendations on High-Risk Breast Cancer Screening All Over the World: Agreements and Differences
Pages 251-267
Selamoglu, Ayla (et al.)
A Soft Option for Primary Prevention: Drugs and Agents
Pages 269-278
Bonanni, Bernardo (et al.)
Surgical Options for Primary Prevention: Prophylactic Mastectomy and Oophorectomy
Pages 279-291
Murphy, James O. (et al.)
Psychological Aspects of High Risk of Breast Cancer
Pages 293-307
Crotti, Nadia (et al.)
Calculating, Using and Improving Individual Breast Cancer Risk Estimates
Pages 309-324
Brentnall, Adam R. (et al.)
MRI for Screening Women with a Personal History of Breast Cancer
Pages 325-341
Bahl, Manisha (et al.)
Breast MRI Screening for the Intermediate Risk: An Open Issue
Pages 343-354
Heywang-Köbrunner, Sylvia H. (et al.)
Hypotheses for the Future
Pages 355-369
Sardanelli, Francesco (et al.)
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