VOLUME 1
Part 1
LABORATORY HEMATOLOGY
Chapter 1
Examination of the Blood and Bone Marrow
1
Kristi J. Smock
Chapter 2
Clinical Flow Cytometry
18
Anna Porwit
Chapter 3
Cytogenetics
48
Patricia T. Greipp, Jess F. Peterson, Linda B. Baughn, and Min Fang
Chapter 4
Molecular Diagnosis in Hematology
Bing Melody Zhang and James L. Zehnder
61
Part 2
THE NORMAL HEMATOLOGIC SYSTEM
SECTION 1
HEMATOPOIESIS
69
Chapter 5
Origin and Development of Blood Cells
69
Daniel K. Borger and Robert T. Means Jr.
SECTION 2
THE ERYTHROCYTE
93
Chapter 6
The Birth, Life, and Death of Red Blood Cells:
Erythropoiesis, the Mature Red Blood Cell, and Cell Destruction
93
John G. Quigley, Robert T. Means Jr., and Bertil Glader
SECTION 3
GRANULOCYTES AND MONOCYTES
136
Chapter 7
Neutrophilic Leukocytes
136
Laura G. Schuettpelz and Daniel C. Link
Chapter 8
The Human Eosinophil
168
Manali Mukherjee, Parameswaran Nair, and Paige Lacy
Chapter 9
Mast Cells and Basophils: Ontogeny, Characteristics,
and Functional Diversity
A. Dean Befus, Marianna Kulka, Kelly M. McNagny, and Judah A. Denburg
Monocytes, Macrophages, and Dendritic Cells
196
Chapter 10
208
Matthew Collin, Venetia Bigley, and Florent Ginhoux
SECTION 4
THE LYMPHOCYTES
233
Chapter 11
Lymphocytes and Lymphatic Organs
Christopher Y. Park and Matthew M. Klairmont
233

Chapter 12
B Lymphocytes
Jeffrey J. Bednarski II
267
Chapter 13
T Lymphocytes
288
Justin C. Boucher, Rawan G. Faramand, and Marco L. Davila
Chapter 14
Natural Killer and Innate Lymphoid Cells
309
Matthew R. Lordo, Todd A. Fehniger, Bethany L. Mundy-Bosse, and Aharon G. Freud
Chapter 15
Major Histocompatibility Complex
322
Qiuheng Jennifer Zhang, Michelle Hickey, Maxim Rosario, Nwe Nwe Soe,
Carrie L. Butler, Rebecca A. Sosa, J. Michael Cecka, and Elaine F. Reed
Chapter 16
Complement System
338
Robert A. Brodsky and Evan M. Braunstein
SECTION 5
HEMOSTASIS
356
Chapter 17
Megakaryocytes
356
William Vainchenker, Najet Debili, and Hana Raslova
Chapter 18
Platelet Structure
391
Elisabeth M. Battinelli and Katie Maurer
Chapter 19
Platelet Function in Hemostasis and Thrombosis
402
David C. Calverley
Chapter 20
Blood Coagulation and Fibrinolysis
427
Stephen J. Everse, Thomas Orfeo, Kathleen E. Brummel-Ziedins, and Kenneth G. Mann
Chapter 21
Endothelium: Angiogenesis and the Regulation of Hemostasis
531
George M. Rodgers
Part 3
TRANSFUSION MEDICINE
Chapter 22
Red Cell, Platelet, and White Cell Antigens
Eric A. Gehrie, Heather M. Smetana, and Paul M. Ness
540
Chapter 23
Transfusion Medicine
558
Mrigender Singh Virk, Suchitra Pandey, and Jennifer Andrews
Part 4
DISORDERS OF RED BLOOD CELLS
SECTION 1
INTRODUCTION
600
Chapter 24
Anemia: General Considerations
Robert T. Means Jr., and Bertil Glader
DISORDERS OF IRON METABOLISM
600
SECTION 2
628
Chapter 25
Iron Deficiency and Related Disorders
628
Elizabeta Nemeth, Marie Hollenhorst, and Lawrence T. Goodnough
Chapter 26
Sideroblastic Anemias
656
Mark D. Fleming
Chapter 27
Hemochromatosis
678
James C. Barton and Charles J. Parker
Chapter 28
Porphyrias
702
Makiko Yasuda, John D. Phillips, and Robert J. Desnick

SECTION 3
HEMOLYTIC ANEMIA
726
Chapter 29
Hereditary Spherocytosis, Hereditary Elliptocytosis,
and Other Disorders Associated With Abnormalities
of the Erythrocyte Membrane
726
Patrick G. Gallagher and Bertil Glader
Chapter 30
Hereditary Hemolytic Anemias Due to Red Blood Cell
Enzyme Disorders
749
Rachael F. Grace and Bertil Glader
Chapter 31
Autoimmune Hemolytic Anemia
770
Richard C. Friedberg and Clara Lo
Chapter 32
Paroxysmal Nocturnal Hemoglobinuria
792
Charles J. Parker and Russell E. Ware
Chapter 33
Acquired Nonimmune Hemolytic Disorders
821
Robert T. Means Jr., and Bertil Glader
SECTION 4
HEREDITARY DISORDERS OF HEMOGLOBIN STRUCTURE
AND SYNTHESIS
833
Chapter 34
Sickle Cell Anemia and Other Sickling Syndromes
833
Parul Rai, Jane Silva Hankins, and Jeremie E. Estepp
Chapter 35
Thalassemia Syndromes: Quantitative Disorders of Globin
Chain Synthesis
883
Eugene Khandros and Janet L. Kwiatkowski
Chapter 36
Hemoglobins With Altered Oxygen Affinity, Unstable Hemoglobins,
M-Hemoglobins, and Dyshemoglobinemias
933
Madeleine Verhovsek and Martin H. Steinberg
SECTION 5
OTHER RED CELL DISORDERS
945
Chapter 37
Megaloblastic Anemias: Disorders of Impaired DNA Synthesis
945
Sally P. Stabler
Chapter 38
Inherited Aplastic Anemia Syndromes Germline
974
Nina Weichert-Leahey and Akiko Shimamura
Chapter 39
Acquired Aplastic Anemia
Amy E. DeZern and Robert A. Brodsky
995
Chapter 40
Red Cell Aplasia: Acquired and Congenital Disorders
1008
Anupama Narla, Jeffrey M. Lipton, and Robert T. Means Jr.
Chapter 41
Congenital Dyserythropoietic Anemias
Theodosia A. Kalfa, Bertil Glader, and Gary Kupfer
1020
Chapter 42
Anemia of Inflammation and of Systemic Disorders
1033
Robert T. Means Jr.
Chapter 43
Anemias During Pregnancy and the Postpartum Period
1047
Robert T. Means Jr.
Chapter 44
Anemias Unique to the Fetus and Neonate
1053
Robert D. Christensen and Robin K. Ohls
Chapter 45
Erythrocytosis
1070
Robert T. Means Jr., and Bertil Glader

Chapter 62
Pathology of Langerhans Cell Histiocytosis and Other
Histiocytic Proliferations
1376
Andrew L. Feldman
Chapter 63
Infectious Mononucleosis and Other Epstein-Barr Virus–Related
Disorders
1382
Laura F. Walsh and Richard F. Ambinder
Chapter 64
Primary Immunodeficiency Diseases
1393
Troy R. Torgerson
Chapter 65
Human Immunodeficiency Virus Infection
1409
Ariela Noy and Roy M. Gulick
Chapter 66
Disorders of the Spleen
1423
William C. Chapman Jr., and William C. Chapman
Chapter 67
Tumors of the Spleen
1437
Daniel A. Arber
Part 7
HEMATOLOGIC MALIGNANCIES
SECTION 1
GENERAL ASPECTS
1444
Chapter 68
Hematopoietic Neoplasms: Principles of Pathologic Diagnosis
1444
Daniel A. Arber
Chapter 69
Principles of Targeted Therapies for Hematologic Malignancies
1454
Nitin Jain, Shilpa Paul, Naveen Pemmaraju, and Varsha Gandhi
Chapter 70
Infectious Complications in Hematologic Malignancies
1468
Markus Plate, Alexander Drelick, and Michael J. Satlin
Chapter 71
Immunotherapy
1494
Trisha R. Berger and Marcela V. Maus
Chapter 72
Gene Therapy for Hematopoietic Stem Cell Disorders
1522
Andre Larochelle
SECTION 2
THE ACUTE LEUKEMIAS
1562
Chapter 73
Molecular Genetics of Acute Leukemia
Ridas Juskevicius, Utpal P. Davé, and Mary Ann Thompson
1562
Chapter 74
Diagnosis and Classification of the Acute Leukemias and
Myelodysplastic Syndromes
1595
Daniel A. Arber and Attilio Orazi
Chapter 75
Acute Lymphoblastic Leukemia in Adults
1608
Ehab Atallah and Kristen O’Dwyer
Chapter 76
Acute Myeloid Leukemia in Adults
1627
Ashkan Emadi and Maria R. Baer
Chapter 77
Acute Lymphoblastic Leukemia in Children
Maureen M. O’Brien, Alix E. Seif, and Stephen P. Hunger
Acute Myeloid Leukemia in Children
Jennifer L. Kamens, Danielle Shin, and Norman Lacayo
1667
Chapter 78
1694
Chapter 79
Acute Promyelocytic Leukemia
1721
Yasmin M. Abaza, Martin S. Tallman, and Jessica K. Altman
Chapter 80
Myelodysplastic Syndromes
1737
Namrata S. Chandhok and Mikkael A. Sekeres
Chapter 81
Clonal Hematopoiesis of Indeterminate Potential
and Myeloid Diseases
1754
Mrinal M. Patnaik and Pinkal Desai

SECTION 3
MYELOPROLIFERATIVE DISORDERS
1763
Chapter 82
Pathology of the Myeloproliferative Neoplasms
1763
Tracy I. George and Devon S. Chabot-Richards
Chapter 83
Chronic Myeloid Leukemia
Ehab Atallah and Michael W. Deininger
1782
Chapter 84
Polycythemia Vera
1808
Laura C. Michaelis and Robert T. Means Jr.
Chapter 85
Myelofibrosis
1821
Andrew T. Kuykendall, Srdan Verstovsek, Eric Padron, and Rami Komrokji
Chapter 86
Eosinophilic Neoplasms and Hypereosinophilic Syndrome
1836
Jason Gotlib
Chapter 87
Systemic Mastocytosis
1849
Dean D. Metcalfe, Jonathan J. Lyons, and Jason Gotlib
SECTION 4
LYMPHOPROLIFERATIVE DISORDERS
1866
Chapter 88
Diagnosis and Classification of Lymphomas
1866
Pedro Horna, Ji Yuan, and Rebecca L. King
Chapter 89
Molecular Genetic Aspects of Non-Hodgkin Lymphomas
1900
Annette S. Kim, Scott B. Lovitch, and Mark A. Murakami
Chapter 90
Non-Hodgkin Lymphoma in Adults
1942
Tarsheen K. Sethi, Shalin Kothari, Erin Mulvey, Francine Foss, John P. Leonard,
and John P. Greer
Chapter 91
Non-Hodgkin Lymphoma in Children
1991
Nitya Gulati and Lisa Giulino-Roth
Chapter 92
Chronic Lymphocytic Leukemia
2010
Sameer A. Parikh, Saad S. Kenderian, Neil E. Kay, and James B. Johnston
Chapter 93
Hairy Cell Leukemia
2049
James B. Johnston, Graeme R. Quest, and Michael R. Grever
Chapter 94
Cutaneous T-Cell Lymphoma: Mycosis Fungoides
and Sézary Syndrome
John A. Zic, Francine Foss, Eva Niklinska, and Jeff P. Zwerner
2072
Chapter 95
Hodgkin Lymphoma in Adults
Reid W. Merryman and Ann LaCasce
Hodgkin Lymphoma in Children
Christine Moore Smith and Debra L. Friedman
2116
Chapter 96
2133
SECTION 5
PLASMA CELL DYSCRASIAS
2144
Chapter 97
Practical Approach to the Evaluation of Monoclonal
Gammopathies
2144
Taxiarchis Kourelis and Francis K. Buadi
Chapter 98
Molecular Genetic Aspects of Plasma Cell Disorders
Peter Leif Bergsagel, Linda B. Baughn, Dragan Jevremovic, and Yan Asmann
Monoclonal Gammopathy of Undetermined Significance and
Smoldering Multiple Myeloma
2152
Chapter 99
2160
S. Vincent Rajkumar, Robert A. Kyle, and Ronald S. Go
Chapter 100 Multiple Myeloma
2175
Wilson I. Gonsalves, Prashant Kapoor, and Shaji K. Kumar
Chapter 101 Immunoglobulin Light Chain Amyloidosis
2238
Morie A. Gertz, Eli Muchtar, and Angela Dispenzieri

Chapter 102 Waldenström Macroglobulinemia
2267
Stephen M. Ansell and Rafael Fonseca
Chapter 103 Monoclonal Gammopathies of Clinical Significance
2276
Angela Dispenzieri, David Dingli, and Rahma Warsam
Part 8
HEMATOPOIETIC CELLULAR THERAPY
Chapter 104 Hematopoietic Cell Transplantation
2297
Rachel B. Salit and Frederick R. Appelbaum
Chapter 105 Hematopoietic Cell Transplantation for Nonmalignant Disorders
2314
Mark C. Walters and Nahal Rose Lalefar
Chapter 106 Hematopoietic Cell Transplantation for Hematologic Malignancies 2335
Bhagirathbhai Dholaria, Jennifer Marvin-Peek, and Bipin N. Savani
Chapter 107 Graft-vs-Host Disease and Graft-vs-Tumor Response 2355
Joseph Pidala, Brian C. Betts, Frederick L. Locke, and Claudio Anasetti
Chapter 108 Late Effects After Hematopoietic Cell Transplantation 2371
Paul A. Carpenter
Index