Titolo: Waldenström’s Macroglobulinemia

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Waldenström’s Macroglobulinemia

Editore

Springer

Anno

2017

Pagine

377

ISBN

9783319225838

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This book sheds new light on clinical, biological and therapeutic data on the rare disease Waldenström’s Macroglobulinemia (WM) with the participation of widely-recognized experts, involved in this field. It represents the efforts of physicians, scientists and patients, all around the world, to better understand and cure this rare disease.

Considerable advances in the diagnosis, treatment indications, response criteria, prognostic factors and treatment options have been made since Dr Jan Waldenström first reported this “new syndrome“ 70 years ago. Particularly instrumental in advancing of our understanding of WM have been the eight international workshops devoted to this disease. New, exciting molecular data have recently been reported, allowing us to revisit the oncogenic events leading to WM B-cell proliferation and to use newly available compounds targeting oncogenic pathways.

Waldenström Macroglobulinaemia: Pathological Features and Diagnostic Assessment

Owen, Roger G. (et al.)

Pages 3-19
Waldenström’s Macroglobulinemia Immunophenotype

Puig, Noemí (et al.)

Pages 21-34
Predispositions and Origins of Waldenstrom Macroglobulinemia: Implications from Genetic Analysis

Pilarski, Linda M. (et al.)

Pages 35-48
Cytogenetics in Waldenström Macroglobulinemia (WM)

Nguyen-Khac, Florence

Pages 49-51
Genetic and Signaling Abnormalities in Waldenstrom’s Macroglobulinemia

Hunter, Zachary R. (et al.)

Pages 53-65

Molecular Pathways in Growth and Survival: Epigenomics

Sacco, Antonio (et al.)

Pages 67-71
The Bone Marrow Microenvironment and Tumor Cells Interactions in Waldenström’s Macroglobulinemia

Kastritis, Efstathios (et al.)

Pages 73-82
Waldenstrom’s Macroglobulinaemia: Immunosurveillance and the Immune Micro-environment

Joshua, D. E. (et al.)

Pages 83-94
Epidemiology of Waldenström Macroglobulinemia

Steingrímsson, Vilhjálmur (et al.)

Pages 97-109
Genetic Predisposition to Waldenström Macroglobulinemia

McMaster, Mary L. (et al.)

Pages 111-141
Immunoglobulin Type M Monoclonal Gammopathy of Undetermined Significance (IgM-MGUS)

McMaster, Mary L. (et al.)

Pages 143-167
Hyperviscosity Syndrome, Cold Agglutinin Hemolytic Anemia, and Cryoglobulinemia

Stone, Marvin J. (et al.)

Pages 171-183
Neuropathy in Waldenström’s Macroglobulinaemia

Viala, Karine (et al.)

Pages 185-194
IgM Amyloidosis

Gertz, Morie A. (et al.)

Pages 195-207
The Bing-Neel Syndrome

Ly, K. Ina (et al.)

Pages 209-221
Unusual Manifestations of IgM Monoclonal Gammopathies

Merlini, Giampaolo (et al.)

Pages 223-236
Laboratory Investigations and Findings: Hematological Abnormalities, Biochemical Investigations, Free Light and Heavy Chains

Fouquet, Guillemette (et al.)

Pages 239-261
Response Assessment in Waldenström’s Macroglobulinaemia

Kimby, Eva (et al.)

Pages 265-275
Risk Stratification in Waldenström Macroglobulinemia

Morel, Pierre (et al.)

Pages 279-293
Indications for Treatment of Waldenström’s Macroglobulinemia

Kyle, Robert A. (et al.)

Pages 297-313
Immunotherapy in Waldenstrom’s Macroglobulinemia

Leblond, Véronique (et al.)

Pages 315-326
Signal Inhibitors in Waldenstrom’s Macroglobulinemia

Treon, Steven P. (et al.)

Pages 327-334
Immunomodulatory Agents and Proteasome Inhibitors in Waldenstrom’s Macroglobulinemia

Treon, Steven P. (et al.)

Pages 335-343
High-Dose Therapy and Haemopoietic Stem Cell Transplantation in Waldenström’s Macroglobulinaemia

Kyriakou, C.

Pages 345-355
Long-Term Toxicity of Therapy in Waldenström Macroglobulinemia

Morra, Enrica (et al.)

Pages 357-365