Non ci sono recensioni
The Evolution and Refinement of Varicocele Treatment: A Historical Perspective
Pages 3-16
This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress.
Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content.
Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.
The Evolution and Refinement of Varicocele Treatment: A Historical Perspective
Pages 3-16
Anatomic Theories of Varicocele Origin
Pages 17-26
Scrotal Hyperthermia, Hormonal Disturbances, Testicular Hypoperfusion, and Backflow of Toxic Metabolites in Varicocele
Pages 27-35
Genetics and Epigenetics of Varicocele Pathophysiology
Pages 37-53
Oxidative Stress and Varicocele Pathophysiology
Pages 55-71
Proteomic and Metabolomic Profile of Semen and Seminal Plasma in Varicocele
Pages 73-85
Experimental Varicocele
Pages 87-94
Epidemiology of Varicocele in Pediatric, Adolescent, and Adult Populations
Pages 97-106
Association Between Varicocele and Infertility
Pages 107-114
Varicocele Clinical Diagnosis and Grading
Pages 115-121
Imaging and Other Diagnostic Modalities in Varicocele Diagnosis
Pages 123-135
Conventional Semen Analysis and Specialized Sperm Function Tests in Patients with Varicocele
Pages 137-157
Endocrine Testing and the Association Between Varicocele and Hypogonadism
Pages 159-169
Varicocele and Orchialgia
Pages 171-182
Medical Therapy in Varicocele-Related Infertility
Pages 185-199
Macroscopic Surgical Techniques for Varicocele Repair
Pages 201-208
Microscopic Surgical Techniques for Varicocele Repair
Pages 209-223
Laparoscopic Techniques for Varicocele Repair
Pages 225-233
Interventional Radiology for Varicocele Treatment
Pages 235-244
Robotic-Assisted Microsurgical Varicocelectomy
Pages 245-253
Effect of Varicocele Treatment on Conventional Semen Analysis
Pages 255-269
Effect of Varicocele Treatment on Oxidative Stress Markers and Sperm DNA Fragmentation
Pages 271-283
Effect of Varicocele Treatment on Natural Pregnancy Outcomes
Pages 285-294
Effect of Varicocele Treatment on Assisted Reproductive Technology (ART) Pregnancy Outcomes
Pages 295-301
Varicocele and Azoospermia
Pages 303-312
Prognostic Factors for a Favorable Outcome After Varicocele Repair in Adults with Infertility
Pages 313-324
Management of Recurrent Varicocele
Pages 325-332
Cost-Effectiveness Analysis of Varicocele Repair and Assisted Reproductive Technology
Pages 333-341
Management of Pediatric and Adolescent Varicocele
Pages 343-355
Is Varicocele a Bilateral Disease?
Pages 359-366
Why Is Subclinical Varicocele Considered a Different Entity?
Pages 367-375
Why Is It That Not All Men with Varicocele Are Infertile?
Pages 377-385
Is There a Role for Testicular Biopsy in Men with Varicocele?
Pages 387-394
Should Bilateral Varicocele Repair Be Recommended in Cases of a Clinical Varicocele and Contralateral Subclinical Varicocele?
Pages 395-403
Is There Any Role for Intraoperative Ultrasound During Varicocele Repair?
Pages 405-413
Is There Any Role for Indocyanine Green Angiography in Testicular Artery Preservation During Microsurgical Subinguinal Varicocelectomy?
Pages 415-424
Should a Varicocele Be Repaired Before Assisted Reproductive Technology Treatment?
Pages 425-432
Should a Varicocele Be Repaired in Non-infertile Patients with Hypogonadism?
Pages 433-442
What Should Be the Ideal Control Group in Clinical Trials Investigating the Role of Varicocele and Its Treatment on Fertility Outcomes?
Pages 443-450
Should Sperm DNA Fragmentation Testing Be Used in Men with Varicocele?
Pages 453-459
Cons: Should Sperm DNA Fragmentation Testing Be Used in Men with Varicocele?
Pages 461-466
Pros: Should Sperm DNA Fragmentation Testing Be Used in Men with Varicocele?
Pages 467-475
Con: Should Varicocele Be Repaired Before ART?
Pages 477-483
Pro: Should Varicocele Be Repaired in Azoospermic Infertile Men?
Pages 485-493
Con: Should Varicocele Be Repaired in Azoospermic Infertile Men?
Pages 495-503
Should Varicoceles Be Managed Surgically or Radiographically? (Surgery)
Pages 505-514
Should Varicocele Be Managed Surgically or Radiographically? (Radiology)
Pages 515-525
Grade 1 Varicocele and Borderline/Normal Conventional Semen Analysis
Pages 529-535
Grades 2/3 Varicocele and Normal Conventional Semen Analysis
Pages 537-543
Clinical Varicocele and Severely Abnormal Semen Analysis in a Couple Considering ART Whose Female Partner Is Over 36 Years Old
Pages 545-550
Asymptomatic Male with Grade 3 Left Varicocele and Two Children with Low Testosterone Levels Desiring Vasectomy
Pages 551-557
Pages 559-563
Recurrent Grade 2/3 Varicocele After Microsurgical Varicocelectomy and Abnormal Semen Parameters in a Couple Attempting Conception for >3 Years
Pages 565-571
Grade 2/3 Varicocele in a 15-Year-Old Healthy Boy with Normal Testis Volume (and Normal Semen Analysis) with a History of Varicocele and Infertility in His Father
Pages 573-577
Adult Varicocele Diagnosis and Treatment
Pages 581-593
Pediatric and Adolescent Varicocele Diagnosis and Treatment
Pages 595-601
Sperm DNA Fragmentation Testing and Varicocele
Pages 603-614
Grade of Evidence on Varicocele Treatment
Pages 615-626
Sei sicuro di voler eseguire questa azione?