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The Evolution and Refinement of Varicocele Treatment: A Historical Perspective
Pages 3-16
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Varicocele and Male Infertility
A Complete Guide
Esteves, Cho, Majzoub, Agarwal
Editore
Springer
Anno
2019
Pagine
638
ISBN
9783319791012
140,00 €
DA SCONTARE
This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress.
Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content.
Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.
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Anatomic Theories of Varicocele Origin
Pages 17-26
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Scrotal Hyperthermia, Hormonal Disturbances, Testicular Hypoperfusion, and Backflow of Toxic Metabolites in Varicocele
Pages 27-35
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Genetics and Epigenetics of Varicocele Pathophysiology
Pages 37-53
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Oxidative Stress and Varicocele Pathophysiology
Pages 55-71
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Proteomic and Metabolomic Profile of Semen and Seminal Plasma in Varicocele
Pages 73-85
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Experimental Varicocele
Pages 87-94
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Epidemiology of Varicocele in Pediatric, Adolescent, and Adult Populations
Pages 97-106
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Association Between Varicocele and Infertility
Pages 107-114
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Varicocele Clinical Diagnosis and Grading
Pages 115-121
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Imaging and Other Diagnostic Modalities in Varicocele Diagnosis
Pages 123-135
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Conventional Semen Analysis and Specialized Sperm Function Tests in Patients with Varicocele
Pages 137-157
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Endocrine Testing and the Association Between Varicocele and Hypogonadism
Pages 159-169
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Varicocele and Orchialgia
Pages 171-182
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Medical Therapy in Varicocele-Related Infertility
Pages 185-199
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Macroscopic Surgical Techniques for Varicocele Repair
Pages 201-208
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Microscopic Surgical Techniques for Varicocele Repair
Pages 209-223
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Laparoscopic Techniques for Varicocele Repair
Pages 225-233
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Interventional Radiology for Varicocele Treatment
Pages 235-244
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Robotic-Assisted Microsurgical Varicocelectomy
Pages 245-253
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Effect of Varicocele Treatment on Conventional Semen Analysis
Pages 255-269
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Effect of Varicocele Treatment on Oxidative Stress Markers and Sperm DNA Fragmentation
Pages 271-283
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Effect of Varicocele Treatment on Natural Pregnancy Outcomes
Pages 285-294
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Effect of Varicocele Treatment on Assisted Reproductive Technology (ART) Pregnancy Outcomes
Pages 295-301
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Varicocele and Azoospermia
Pages 303-312
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Prognostic Factors for a Favorable Outcome After Varicocele Repair in Adults with Infertility
Pages 313-324
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Management of Recurrent Varicocele
Pages 325-332
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Cost-Effectiveness Analysis of Varicocele Repair and Assisted Reproductive Technology
Pages 333-341
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Management of Pediatric and Adolescent Varicocele
Pages 343-355
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Is Varicocele a Bilateral Disease?
Pages 359-366
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Why Is Subclinical Varicocele Considered a Different Entity?
Pages 367-375
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Why Is It That Not All Men with Varicocele Are Infertile?
Pages 377-385
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Is There a Role for Testicular Biopsy in Men with Varicocele?
Pages 387-394
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Should Bilateral Varicocele Repair Be Recommended in Cases of a Clinical Varicocele and Contralateral Subclinical Varicocele?
Pages 395-403
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Is There Any Role for Intraoperative Ultrasound During Varicocele Repair?
Pages 405-413
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Is There Any Role for Indocyanine Green Angiography in Testicular Artery Preservation During Microsurgical Subinguinal Varicocelectomy?
Pages 415-424
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Should a Varicocele Be Repaired Before Assisted Reproductive Technology Treatment?
Pages 425-432
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Should a Varicocele Be Repaired in Non-infertile Patients with Hypogonadism?
Pages 433-442
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What Should Be the Ideal Control Group in Clinical Trials Investigating the Role of Varicocele and Its Treatment on Fertility Outcomes?
Pages 443-450
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Should Sperm DNA Fragmentation Testing Be Used in Men with Varicocele?
Pages 453-459
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Cons: Should Sperm DNA Fragmentation Testing Be Used in Men with Varicocele?
Pages 461-466
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Pros: Should Sperm DNA Fragmentation Testing Be Used in Men with Varicocele?
Pages 467-475
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Con: Should Varicocele Be Repaired Before ART?
Pages 477-483
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Pro: Should Varicocele Be Repaired in Azoospermic Infertile Men?
Pages 485-493
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Con: Should Varicocele Be Repaired in Azoospermic Infertile Men?
Pages 495-503
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Should Varicoceles Be Managed Surgically or Radiographically? (Surgery)
Pages 505-514
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Should Varicocele Be Managed Surgically or Radiographically? (Radiology)
Pages 515-525
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Grade 1 Varicocele and Borderline/Normal Conventional Semen Analysis
Pages 529-535
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Grades 2/3 Varicocele and Normal Conventional Semen Analysis
Pages 537-543
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Clinical Varicocele and Severely Abnormal Semen Analysis in a Couple Considering ART Whose Female Partner Is Over 36 Years Old
Pages 545-550
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Asymptomatic Male with Grade 3 Left Varicocele and Two Children with Low Testosterone Levels Desiring Vasectomy
Pages 551-557
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Symptomatic Male with Subclinical Varicocele Found on Ultrasound Evaluation
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Pages 559-563
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Recurrent Grade 2/3 Varicocele After Microsurgical Varicocelectomy and Abnormal Semen Parameters in a Couple Attempting Conception for >3 Years
Pages 565-571
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Grade 2/3 Varicocele in a 15-Year-Old Healthy Boy with Normal Testis Volume (and Normal Semen Analysis) with a History of Varicocele and Infertility in His Father
Pages 573-577
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Adult Varicocele Diagnosis and Treatment
Pages 581-593
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Pediatric and Adolescent Varicocele Diagnosis and Treatment
Pages 595-601
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Sperm DNA Fragmentation Testing and Varicocele
Pages 603-614
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Grade of Evidence on Varicocele Treatment
Pages 615-626
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