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Libreria medica internazionale
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Understanding Cancer
The Molecular Mechanisms, Biology, Pathology and Clinical Implications of Malignant Neoplasia
Tarin
Editore
Springer
Anno
2023
Pagine
325
ISBN
9783030973957
220,00 €

DA SCONTARE

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

This book provides a unique, wide-ranging description of the phenomenon of cancer and its pathological effects in diverse species including humans, domesticated and wild animals, invertebrates, and plants. The broad scope of information presented is used to construct radical new insights into biological self-regulation and explain their relevance to its disruption by cancerous growth and spread within the human body.

Mechanisms of action of carcinogenic agents, initiation, progression, metastasis, inappropriate gene expression, dormancy, latency, regression, and reasons for susceptibility and/or resistance to cancer are all considered. Also discussed are criteria for pathological diagnosis, advances in treatment, implications for public health, and pitfalls in diagnosis and interpretation of experimental results.

    The book describes operational mechanisms of cancer at the levels of whole individual, organ, tissue, cell, molecular, and even atomic (quantum) scales of structural and physiological order.

    Evidence is assembled from all these levels of organization to show that cancer is a dynamically changing disorder and that it is an inherent and perpetual risk of multicellular composition. This provides pragmatic new biological and clinical perspectives on malignant neoplasia.  The biological insight is that it is a consequence of progressing miscommunication within a cellular society.

    The clinical perspective is realistic but optimistic in reasoning that, although cancer can never be completely eradicated from human life, because it is a disorder of our intrinsic biological constitution, it can be controlled and ameliorated and even cured in a proportion of individuals.

    The text is profusely illustrated with over 300 macroscopic and microscopic pictures. It will stimulate curiosity and interest specialists, as well as beginners, in many scientific disciplines and provides copious references to the medical and scientific literature supporting its conclusions.

    Readers from fields as diverse as medicine, pathology, veterinary sciences, cell biology, molecular biology, developmental biology, and epidemiology will find the information the book contains thought-provoking, interesting, and useful. Additionally, specialists in occupational and environmental health and legal experts focusing on exposure to carcinogenic materials and pollution will find the contents valuable and informative.


Front Matter
Pages i-xxv
PDF
Defining Cancer: Comparisons of Normal Development and Cancer Formation

    Front Matter
    Pages 1-1
    PDF
    Understanding the Nature of Cancer–General Principles
        David Tarin
    Pages 3-26
    The Phenomenon of Inappropriate Gene Expression and Its Biological and Clinical Consequences
        David Tarin
    Pages 27-57

The Tumour “System”—Pathology and Pathophysiology of the Tumour Microenvironment

    Front Matter
    Pages 59-59
    PDF
    The Tumour System
        David Tarin
    Pages 61-91
    The Host Stroma and the Tumour Microenvironment
        David Tarin
    Pages 93-110

Prevalence of Cancer in Nature and History of Study of the Disease

    Front Matter
    Pages 111-111
    PDF
    The Biology and Natural History of Cancer
        David Tarin
    Pages 113-139
    Major Events in the History of Medical Understanding of Cancer
        David Tarin
    Pages 141-154

Causes and Mechanisms of Cancer Formation, Invasion, Metastasis and Associated Symptoms: Clinical and Experimental Studies

    Front Matter
    Pages 155-155
    PDF
    The Behaviour of Cancers: Invasion and Metastasis I. Clinico-Pathological Aspects
        David Tarin
    Pages 157-173
    The Behaviour of Cancers: Invasion and Metastasis II. Experimental Analysis of Mechanisms
        David Tarin
    Pages 175-227
    Causes of Cancer and Mechanisms of Carcinogenesis
        David Tarin
    Pages 229-279
    Paraneoplastic Syndromes
        David Tarin
    Pages 281-300

Synthesis and Significance of a New Perspective on Malignancy

    Front Matter
    Pages 301-301
    PDF
    Clinical Implications of Multi-level (Scalar) Disorganisation in Cancer
        David Tarin
    Pages 303-313
    Understanding the Significance of Cancer in the Overall Spectrum of Disease
        David Tarin
    Pages 315-318

Back Matter
Pages 319-325

 

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