Titolo: Tumor Liquid Biopsies

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Oncologia e Radioterapia

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Tumor Liquid Biopsies

Recent Results in Cancer Research

Editore

Springer

Anno

2020

Pagine

368

ISBN

9783030264383

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC

Pages 3-24

Todenhöfer, Tilman (et al.)
Circulating Tumor Cell Enrichment Technologies

Pages 25-55

Boya, Mert (et al.)
Genetic Analysis of Circulating Tumour Cells

Pages 57-76

Kolinsky, Michael Paul (et al.)
Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring

Pages 77-88

Kalinich, Mark (et al.)
Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis

Pages 89-104

Keomanee-Dizon, Kevin (et al.)

Circulating Tumour Cells in Lung Cancer

Pages 105-125

Chemi, Francesca (et al.)
Circulating Tumor Cells in Breast Cancer

Pages 127-145

Liang, Diana H. (et al.)
Clinical Applications of Circulating Tumor Cells in Breast Cancer

Pages 147-160

Cobain, Erin F. (et al.)
Pathophysiology of ctDNA Release into the Circulation and Its Characteristics: What Is Important for Clinical Applications

Pages 163-180

Papadopoulos, Nickolas
Enrichment and Analysis of ctDNA

Pages 181-211

Gilson, Pauline
Capturing Tumor Heterogeneity and Clonal Evolution by Circulating Tumor DNA Profiling

Pages 213-230

Scherer, Florian
Review ctDNA and Breast Cancer

Pages 231-252

Clatot, Florian
Cell-Free DNA in the Management of Colorectal Cancer

Pages 253-261

Harlé, Alexandre
Dynamic Treatment Stratification Using ctDNA

Pages 263-273

Vidal, Joana (et al.)
Circulating miRNAs as Biomarker in Cancer

Pages 277-298

Andersen, Gitte Brinch (et al.)
Circulating MicroRNAs as Potential Biomarkers for Lung Cancer

Pages 299-318

Müller, Sabrina (et al.)
Extracellular Vesicles: Recent Developments in Technology and Perspectives for Cancer Liquid Biopsy

Pages 319-344

Nazarenko, Irina
Computational Analysis of DNA and RNA Sequencing Data Obtained from Liquid Biopsies

Pages 347-368

Marass, Francesco (et al.)