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The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities.
Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
Historical Perspective of Trauma-Induced Coagulopathy
Pages 3-11
Moore, Ernest E. (et al.)
Epidemiology of Hemorrhage-Related Mortality
Pages 13-27
Sauaia, Angela (et al.)
Cell-Mediated Hemostasis
Pages 31-41
Hoffman, Maureane
Thrombin-Antithrombin System
Pages 43-51
Iba, Toshiaki
Physiology of Haemostasis: Plasmin-Antiplasmin System
Pages 53-74
Mutch, Nicola J. (et al.)
Thrombin Formation
Pages 77-84
Bouchard, Beth A. (et al.)
Platelets
Pages 85-99
Matthay, Zachary A. (et al.)
Fibrinogen
Pages 101-116
White, Nathan J. (et al.)
Defining and Assessing the Endotheliopathy of Trauma and Its Implications on Trauma-Induced Coagulopathy and Trauma-Related Outcomes
Pages 117-133
Nair, Alison Baker (et al.)
Protein C
Pages 135-156
Sumislawski, Joshua J. (et al.)
Fibrinolysis Dysregulation Following Trauma
Pages 157-174
Moore, Hunter B. (et al.)
Complement System
Pages 175-197
Popescu, Narcis I. (et al.)
Neutrophils, Inflammation, and Innate Immunity in Trauma-Induced Coagulopathy
Pages 199-216
Barrett, Christopher D. (et al.)
Disseminated Intravascular Coagulation
Pages 217-242
Gando, Satoshi (et al.)
Grading Clinical Coagulopathy and Predicting Massive Transfusion
Pages 245-263
Thorn, Sophie (et al.)
Prothrombin and Partial Thromboplastin Time
Pages 265-270
Crowe, Elizabeth P. (et al.)
Fibrinogen Assays
Pages 271-278
Schlimp, Christoph J. (et al.)
Rotational Thromboelastometry (ROTEM®)
Pages 279-312
Görlinger, Klaus (et al.)
Thromboelastography (TEG® 5000 and TEG® 6s Hemostasis Analyzers with TEG Manager® Software)
Pages 313-331
Hartmann, Jan (et al.)
Red Blood Cell Transfusion
Pages 335-351
Winkler, Anne M.
Plasma Transfusion
Pages 353-371
Brill, Jason B. (et al.)
Cryoprecipitate/Fibrinogen Concentrate Transfusions
Pages 373-390
Davenport, Ross A. (et al.)
Platelet Transfusion
Pages 391-428
Meledeo, Michael Adam (et al.)
Whole Blood for the Resuscitation of Massively Bleeding Civilian Patients
Pages 429-442
Yazer, Mark H. (et al.)
Adjunct Factor Replacement
Pages 443-454
Gallaher, Jared R. (et al.)
Anti-fibrinolytics
Pages 455-472
Draxler, Dominik F. (et al.)
Ratio-Driven Massive Transfusion Protocols
Pages 473-486
Stephenson, Krista J. (et al.)
Goal-Directed Massive Transfusion Management
Pages 487-494
Nunns, Geoffrey Rogan (et al.)
Prehospital Resuscitation
Pages 495-512
Deeb, Andrew-Paul (et al.)
Venous Thromboembolism After Trauma
Pages 515-533
Meizoso, Jonathan P. (et al.)
Fibrinolysis Shutdown and Venous Thromboembolism
Pages 535-546
Stettler, Gregory R. (et al.)
Congenital and Acquired Hypercoagulable States
Pages 547-565
Emmerich, Joseph
Pediatrics
Pages 569-582
Lucisano, Amelia C. (et al.)
Traumatic Brain Injury-Induced Coagulopathy
Pages 583-606
Dong, Jing-fei (et al.)
Blunt Solid Organ Injury: A Call for Timely Chemoprophylaxis in the Setting of Early Hypercoagulability
Pages 607-616
Coleman, Julia R. (et al.)
Pregnancy
Pages 617-633
Katz, Daniel
Liver Failure
Pages 635-647
Tanaka, Kenichi A. (et al.)
Pulmonary Coagulation in the Pathogenesis of Trauma-Associated Acute Respiratory Distress Syndrome
Pages 649-662
Langouët-Astrié, Christophe J. (et al.)
Management of Chronically Anticoagulated Patients
Pages 663-676
Levy, Jerrold H.
Randomized Controlled Trials: Informing Clinical Practice for Traumatically Injured Patients
Pages 679-692
Reitz, Katherine M. (et al.)
The Quantra® System and SEER Sonorheometry
Pages 693-704
Allen, Todd W. (et al.)
Dried Plasma for Trauma Resuscitation
Pages 705-718
Pusateri, Anthony E. (et al.)
Synthetic Blood Substitutes
Pages 719-743
Gupta, Anirban Sen
Flow-Based Coagulation and Fibrinolysis Assays
Pages 745-762
Sorrells, Matthew (et al.)
Animal Models of Coagulopathy
Pages 763-779
Lammers, Daniel (et al.)
Applications of Viscoelastic Hemostatic Assays at the Site of Care: Considerations and Implications
Pages 781-786
Hartmann, Jan (et al.)
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