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Now in its fully revised and expanded second edition, this textbook remains the definitive resource on pancreas transplantation. Enlarged, updated and improved, it consists of 93 chapters over 11 sections, with chapter authors who are recognized international leaders in their fields and represent institutions from five continents.
Since the publication of the original edition in 2004, substantial progress has been made in the field of pancreas transplantation, specifically in regard to standardization of operative techniques and immunosuppression; significant improvements in patient and graft survival rates; and improved diagnosis and therapy of graft rejection and recurrence of disease. Pancreas transplants are no longer primarily performed in the USA and Europe for Type 1 diabetes mellitus; over the past 15 years, they have been performed with increasing frequency worldwide and also for Type 2 diabetes mellitus.
The new edition of this textbook covers all aspects of pancreas transplantation: indications, recipient categories, surgical donor and recipient techniques, living donor transplantation, postoperative management and follow-up, post-transplant complications and malignancies, immunosuppression, treatment and diagnosis of rejection, impact on endocrine function and secondary complications of diabetes, recurrence of disease, quality of life, economic issues and overall outcome results. In addition, state-of-the art chapters focus on the classification, epidemiology and pathogenesis of Type 1 and 2 diabetes mellitus as well as on other beta-cell replacement therapies including islet auto- and allo-transplantation.
This textbook is the primary reference on pancreas transplantation for transplant surgeons (established and in-training), pancreas and HPB surgeons, diabetologists, endocrinologists, gastroenterologists, pancreatologists and other health professionals with a focus on transplantation and diabetes (cardiologists, neurologists, urologists, ophthalmologists).
Front Matter
Pages 1-1
Diabetes Mellitus: Classification and Diagnosis
Pages 3-12
Epidemiology and Pathogenesis of Type 1 Diabetes
Pages 13-39
Epidemiology and Pathogenesis of Type 2 Diabetes
Pages 41-53
Medical Management of Diabetes Mellitus: Options and Limitations
Pages 55-57
History of Pancreas Transplantation
Pages 59-92
Experimental Pancreas Transplantation
Pages 93-113
Front Matter
Pages 115-115
Pancreas Allocation in the United States
Pages 117-128
Pancreas Allocation in the Eurotransplant Area
Pages 129-139
Pancreas Allocation in the United Kingdom
Pages 141-150
Pancreas Allocation in Australasia
Pages 151-157
Pages 159-166
Donor Selection and Management
Pages 167-178
Pages 179-187
Donor Procurement After Brain Death
Pages 189-202
Donor Procurement After Circulatory Death
Pages 203-214
Pages 215-230
Surgical Back-Table Procedures
Pages 231-242
Front Matter
Pages 243-243
Patient Selection: Pancreas or Islet Transplantation
Pages 245-255
One Waiting List for Pancreas and Islet Transplantation: The Canadian Experience
Pages 257-261
One Waiting List for Pancreas and Islet Transplantation: The United Kingdom Experience
Pages 263-268
Pancreas Transplant Recipient Categories
Pages 269-270
Simultaneous Pancreas and Kidney Transplantation
Pages 271-283
Pancreas After Kidney Transplantation
Pages 285-289
Pancreas Transplantation Alone
Pages 291-305
Pages 307-325
Pages 327-337
Pages 339-345
Pages 347-352
Standard Open Procedures from Deceased Donors
Pages 353-408
Gastric Drainage: The United States Experience
Pages 409-417
Duodenal Drainage: The South American Experience (Brazil)
Pages 419-427
Duodenal Drainage: The European Experience (Germany)
Pages 429-432
Robotic Pancreas Transplantation: The European Experience (Italy)
Pages 433-450
Robotic Pancreas Transplantation: The United States Experience
Pages 451-455
Living Donor Pancreas Transplantation
Pages 457-466
Pancreas-Multivisceral Transplantation
Pages 467-477
Front Matter
Pages 479-479
Pages 481-486
Pages 487-508
Pages 509-528
Front Matter
Pages 529-529
Initial Transplant Hospitalization
Pages 531-542
Pages 543-552
Pages 553-583
Pages 585-595
Pages 597-604
Pages 605-614
Post-transplant Lymphoproliferative Disease
Pages 615-622
Non-immunological Endocrine Graft Dysfunction
Pages 623-629
Front Matter
Pages 631-631
Pages 633-654
Pages 655-673
Immunobiology, Diagnosis, and Treatment of Rejection
Pages 675-704
Pages 705-725
Crossmatch Positivity: The Khalid Khwaja Memorial Chapter
Pages 727-733
Pages 735-754
Pages 755-763
Donor Bone Marrow Conditioning, Chimerism, and Tolerance Induction
Pages 765-779
Recurrence of Type 1 Diabetes Mellitus
Pages 781-797
Front Matter
Pages 799-799
Endocrine Function and Metabolic Outcomes After Pancreas and Islet Transplantation
Pages 801-815
Pages 817-830
Pages 831-844
Pages 845-857
Pages 859-874
Pages 875-881
Cardio-Cerebro-Vascular Disease
Pages 883-895
Secondary Complications: Pancreas Versus Islet Transplantation
Pages 897-911
Front Matter
Pages 913-913
Defining Outcomes for β-Cell Replacement Therapy
Pages 915-923
Pages 925-960
Survival Benefit of Pancreas Transplantation
Pages 961-967
Outcome of Donation After Circulatory Death
Pages 969-974
Management of the Failing Pancreas Graft
Pages 975-987
Pages 989-998
Type 2 Diabetes Mellitus, Minorities, the Young and Elderly
Pages 999-1022
Pages 1023-1028
Long-Term Pancreas Graft Function
Pages 1029-1038
Pages 1039-1052
Pregnancy After Pancreas Transplantation
Pages 1053-1059
Front Matter
Pages 1061-1061
Formulas for Successful Pancreas Transplant Programs
Pages 1063-1068
Accreditation and Certification in the United States
Pages 1069-1076
Accreditation and Certification in Europe
Pages 1077-1085
Pages 1087-1098
Front Matter
Pages 1099-1099
Treatment of Pancreatic Exocrine Disorders by Pancreas and Islet Transplantation
Pages 1101-1112
Total Pancreatectomy and Islet Autotransplantation: Surgical Procedures
Pages 1113-1132
Total Pancreatectomy and Islet Autotransplantation: Islet Isolation
Pages 1133-1148
Total Pancreatectomy and Islet Autotransplantation: Outcome and Metabolism
Pages 1149-1155
Pages 1157-1204
Pancreas After Islet Transplantation
Pages 1205-1210
Front Matter
Pages 1211-1211
First World Consensus Conference on Pancreas Transplantation
Pages 1213-1239
Global Expansion: Pancreas Transplantation in Africa
Pages 1241-1246
Global Expansion: Pancreas Transplantation in China
Pages 1247-1252
Global Expansion: Pancreas Transplantation in Latin and South America
Pages 1253-1255
Global Expansion: Pancreas Transplantation in Russia
Pages 1257-1265
The Impact of the COVID-19 Pandemic on Pancreas Transplantation
Pages 1267-1273
The Endocrinologist’s View: Strengthening Future Pancreas Transplantation Programs in Europe
Pages 1275-1279
Pages 1281-1283
Pages 1285-1304
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