Introduction

Part I: Ovarian Cancer

Chapter 1. Origins of Epithelial Ovarian Cancer

• Abstract
• Introduction
• Embryonic Development
• Serous EOC
• Endometrioid EOC
• Mucinous EOC
• Clear Cell Carcinoma
• Concluding Remarks
• References

Chapter 2. Ovarian Cancer Genomics

• Abstract
• Introduction
• Low-Grade Serous Ovarian Cancer
• Clear Cell Ovarian Cancer
• Mucinous Ovarian Cancer
• Advanced Stage Serous Ovarian Cancer
• Generation of Clinically Relevant Signatures in OC
• Gene Expression Signatures for Drug Sensitivity in OC
• Recurrent Ovarian Cancer
• Conclusion
• List of Acronyms and Abbreviations
• References

Chapter 3. Epigenetics

• Abstract
• Introduction
• Epigenetic Changes in Ovarian Cancer
• Expression and Function of Epigenome Modifying Enzymes in OC
• Functional Consequences of Epigenetic Alterations in OC
• Therapeutic Targeting of the OC Epigenome
• Conclusion
• References

Chapter 4. Timing of Cytoreductive Surgery in the Treatment of Advanced Epithelial Ovarian Carcinoma

• Abstract
• Introduction
• History of Ovarian Cancer Surgery: Defining “Optimal”
• The Quest for Complete Gross Resection: a Radical Approach
• Chemotherapy Then and Now: When and How?
• Primary Versus Interval Cytoreduction: Rationale
• Interval Debulking Surgery: a Second Chance
• Neoadjuvant Chemotherapy: Planned from the Start
• Predicting Surgical Success: Translational Advances
• In Conclusion: What Now?
• References

Chapter 5. Angiogenesis

• Abstract
• Introduction
• Angiogenesis
• Vessel Sprouting Model
• Tumor Angiogenesis
• Growth Factor Pathways in Gynecologic Cancers
• Antiangiogenic Therapies in Clinical Trials
• Monoclonal Antibodies
• Receptor Kinase Inhibitors
• Fusion Peptibody
• Combination Biologic Therapy
• Resistance to Antiangiogenic Therapies
• Biomarkers
• Conclusion
• Glossary
• List Of Acronyms and Abbreviations
• References

Chapter 6. Homologous Recombination and BRCA Genes in Ovarian Cancer: Clinical Perspective of Novel Therapeutics

• Abstract
• Introduction
• HR and Double-Strand DNA Break Repair
• HR and Epithelial Ovarian Cancer
• Targeting HRD in Ovarian Cancer
• Promoting HR Deficiency in HR-Proficient Cells
• Conclusion
• References

Chapter 7. Molecular Basis of PARP Inhibition and Future Opportunities in Ovarian Cancer Therapy

• Abstract
• DNA Damage Response
• BRCA Gene Mutations
• BRCA Genotype-Phenotype Associations
• Other Ovarian Cancer Associated Syndromes
• FA-BRCA Pathway
• More Than Just BRCA: Strong Penetrance Genes
• FA-Related Moderate Penetrance Genes
• Low Penetrance Genes
• BRCA Testing for Ovarian Cancer
• Screening and Prophylactic Surgery
• Poly (ADP-Ribose) Polymerase
• PARP Inhibitor Mechanism and Early Clinical Development History
• Clinical Studies of PARP Inhibitors in Ovarian Cancer: Olaparib
• Go-No-Go Decision
• Registration Strategies
• Combination Therapy
• Other PARP Inhibitors
• Predicting Response to PARP Inhibitor Therapy
• Combating Mechanisms of PARP Inhibitor Resistance
• Other Potential Opportunities
• Other DNA Repair Targeted Therapies
• Conclusion
• References

Chapter 8. Ovarian Cancer: New Targets and Future Directions

• Abstract
• Introduction
• Immunotherapy
• Folate Receptor-Targeted Therapy
• Fibroblast Growth Factor Targeting
• PI3K/AKT/mTOR Signaling
• RAS/RAF/MEk/ERK Pathway Inhibition
• p53
• Conclusion
• References

Chapter 9. Novel Chemotherapy Tools: Intraperitoneal Therapy, Dose-Dense Therapy

• Abstract
• Introduction
• Intraperitoneal Therapy
• Dose-Dense Therapy
• Conclusions
• List of Acronyms and Abbreviations
• References

Chapter 10. Updates on Rare Epithelial Ovarian Carcinoma

• Abstract
• Introduction: Epithelial Ovarian Cancer Subtypes
• Low-Grade Serous Carcinoma
• Clear Cell Carcinoma
• Endometrioid Ovarian Carcinoma
• Mucinous Ovarian Carcinoma
• Future Directions
• Conclusions
• References

Part II: Endometrial Cancer

Chapter 11. Endometrial Cancer Genomics

• Abstract
• Introduction
• The Genomics of EECs
• The Genomics of SECs
• The Potential Clinical Utility of Genomic Aberrations in ECs
• The Genomics of UCSs/MMMTs
• Genetic Predisposition to EC
• Conclusion
• Glossary
• List of Acronyms and Abbreviations
• References

Chapter 12. Sentinel Lymph Node Mapping Procedures in Endometrial Cancer

• Abstract
• Introduction
• Sentinel Lymphatic Mapping
• Technique in Endometrial Cancer
• Pathologic Ultrastaging
• Prospective Evaluation
• Incorporation Into an Algorithm
• Conclusion
• References

Chapter 13. The Role of Radiation in Uterine Cancer

• Abstract
• Introduction
• Radiobiology and Radiosensitizers
• Radiation in Early Stage Uterine Cancer
• Locally Advanced Uterine Cancer
• Radiation Delivery Methods
• Medically Inoperable Uterine Cancer
• Conclusion
• List of Acronyms and Abbreviations
• References

Part III: Cervical Cancer

Chapter 14. Novel Therapies for Advanced Cervical Cancer

• Abstract
• Introduction to Cervical Cancer
• The Angiogenesis Story
• Immunotherapeutic Approaches
• Other Promising Therapeutic Strategies
• References

Part IV: Vulvar Cancer

Chapter 15. New Therapies in Vulvar Cancer

• Abstract
• Introduction
• Sentinel Lymph Node Procedure
• Radiotherapy in Vulvar Cancer Patients with a Positive Sentinel Node
• Targeted Therapies
• Conclusion
• Research Agenda
• References

Part V: Fertility and Cancer

Chapter 16. Fertility and Cancer: Fertility Preservation and Fertility Sparing Surgery

• Abstract
• Surgery
• FSS Summary
• Radiation
• Chemotherapy
• Fertility Preservation Efforts and Techniques
• Additional Topics
• References