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In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely.
This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded.
Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists.
Thyroid and the Heart: A Historical Perspective
Pages 3-11
Sgarbi, José Augusto
Physiological Role of Thyroid Hormone in the Developing and Mature Heart
Pages 13-22
Rutigliano, Grazia (et al.)
Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature
Pages 23-41
Ojamaa, Kaie (et al.)
Cardiac Metabolic Changes in Altered Thyroid States
Pages 45-56
Portman, Michael A.
Diastolic and Systolic Dysfunction of the Heart and Thyroid Hormone Abnormalities
Pages 57-67
Tang, Yi-Da
TH Metabolism in Ischemia/Reperfusion Models
Pages 71-83
Kusmic, Claudia (et al.)
Thyroid Hormone Deiodinative Pathways in the Normal and Failing Heart
Pages 85-96
Simonides, Warner S.
TH Metabolism and Active TH Metabolites in the Heart
Pages 97-107
Saponaro, Federica (et al.)
Thyroid Hormone, Mitochondrial Function and Cardioprotection
Pages 109-126
Forini, Francesca (et al.)
Thyroid Hormone and Vascular Remodeling in Heart
Pages 127-136
Balzan, Silvana (et al.)
Physiological and Pathological Cardiac Remodeling in Altered Thyroid Hormone States
Pages 137-152
Rajagopalan, Viswanathan (et al.)
Thyroid Hormone and Cardiac Repair
Pages 153-162
Pantos, Constantinos
The Role of Thyroid Hormone Receptor α1 in Cardiac Repair
Pages 163-170
Mourouzis, Iordanis
The Thyroid-Oxidative Stress Axis in Heart Failure
Pages 171-186
Gaggini, Melania (et al.)
Thyroid Genetics and the Cardiovascular System
Pages 187-202
Kuś, Aleksander (et al.)
Thyroid and Cardiovascular Risk
Pages 205-227
Elzen, Wendy P. J. (et al.)
Heart in Overt and Subclinical Hypothyroidism
Pages 229-237
Biondi, Bernadette
Blood Pressure in Thyroid Dysfunction
Pages 239-243
Jabbar, Avais (et al.)
Thyroid, Lipids, and Risk of Atherosclerosis
Pages 245-262
Brenta, Gabriela (et al.)
Arrhythmias in Thyroid Disorders
Pages 263-277
Marrakchi Meziou, Sonia (et al.)
Thyroid Hormone Abnormalities in Myocardial Infarction
Pages 279-299
Varvarousis, Dimitrios (et al.)
Thyroid, Heart Failure, and Neuroendocrine Activation
Pages 301-309
Emdin, Michele (et al.)
Heart Drugs and Influences on TH Metabolism
Pages 311-325
Bogazzi, Fausto (et al.)
Thyroid Dysfunction and Cardiovascular Disease in Chronic Kidney Disease
Pages 327-338
Zoccali, Carmine (et al.)
Thyroid Hormones, Brain, and Heart
Pages 339-360
Burkauskas, Julius (et al.)
Modalities of Thyroid Hormone Administration and Correlates Between Blood and Tissue Levels
Pages 363-372
Celi, Francesco S.
TH Treatment in Patients with Cardiac Disorders: General Aspects and Rationale
Pages 373-380
Sabatino, Laura
Thyroid Hormone Treatment in Acute Myocardial Infarction
Pages 381-389
Razvi, Salman
TH Treatment in HF
Pages 391-407
Pingitore, Alessandro (et al.)
Thyroid Hormone Treatment in Heart Surgery and Heart Transplantation
Pages 409-436
Novitzky, Dimitri (et al.)
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