Table of Contents

List of Contributors viii

Preface xii

Section I Neurocognitive Mechanisms of Addiction 1

1 Addiction as Maladaptive Learning, with a Focus on Habit Learning 3
Theresa H. McKim and Charlotte A. Boettiger

2 Neural Bases of Addiction ]Related Impairments in Response Inhibition 29
Hugh Garavan, Alexandra S. Potter, Katie L. Brennan, and John J. Foxe

3 Working Memory Functioning and Addictive Behavior: Insights from Cognitive Neuroscience 55
Travis T. Nichols and Stephen J. Wilson

Section II Neurocognitive Mechanisms of Addiction: Reward, Motivation, and Decision Making 77

4 Behavioral and Brain Response to Non ]Drug Rewards in Substance Abuse: Implications for Motivational Theories of Addiction 79
James M. Bjork

5 Role of the Value Circuit in Addiction and Addiction Treatment 109
Anna B. Konova and Rita Z. Goldstein

6 The Insula: A Critical Neural Substrate for Drug Seeking under Conflict and Risk 128
Nasir H. Naqvi and Antoine Bechara

7 Addiction as a Symptom of Failure Modes in the Machineries of Decision Making 151
A. David Redish

Section III Neurocognitive Mechanisms of Addiction 173

8 The Role of Sensory and Motor Brain Regions in Drug ]Cue Reactivity 175
Yavor Yalachkov, Jochen Kaiser, and Marcus J. Naumer

9 Neural Mechanisms Underlying Craving and the Regulation of Craving 195
Hedy Kober and Maggie Mae Mell

10 Neurobiology of Alcohol Craving and Relapse Prediction: Implications for Diagnosis and Treatment 219
Corinde E. Wiers and Andreas Heinz

11 Neural Mechanisms Associated with Stress ]Induced Drug Craving 240
Verica Milivojevic, Helen C. Fox, and Rajita Sinha

Section IV Cognitive Neuroscience and the Development of Addiction 267

12 Neurological Risk Factors for the Development of Problematic Substance Use 269
Sylia Wilson, Kathleen M. Thomas, and William G. Iacono

13 Adolescence and Addiction : Vulnerability, Opportunity, and the Role of Brain Development 292
David M. Lydon, Adriana Galván, and Charles F. Geier

14 Neurocognition and Brain Abnormalities among Adolescent Alcohol and Drug Users 311
Anita Cservenka and Bonnie J. Nagel

Section V Cognitive Neuroscience and the Treatment of Drug Addiction 333

15 The Neurocognitive Mechanisms Underlying Psychosocial Interventions for Addiction: Motivational Interviewing as a Case Study 335
Sarah W. Feldstein Ewing and Jon M. Houck

16 Brain Stimulation as a Novel Technique for Craving Management and the Treatment of Addiction 357
Aviad Hadar and Abraham Zangen

17 Development of Real ]Time fMRI Neurofeedback for Craving in Nicotine ]Dependent Cigarette Smokers 390
Karen J. Hartwell, Kathleen T. Brady, and Mark S. George

Section VI Emerging Themes and Future Directions 405

18 Advancing Addiction Research through the Integration of Genetics and Neuroimaging 407
Hollis C. Karoly, Sarah L. Hagerty, Barbara J. Weiland, and Kent E. Hutchison

19 Neuroeconomic Perspectives on the Potent but Inconsistent Motivations Characteristic of Addiction 440
A. James Melrose, Eustace Hsu and John Monterosso

20 Beyond Functional Localization: Advancing the Understanding of Addiction-Related Processes by Examining Brain Connectivity 472
Matthew T. Sutherland, Xia Liang, Yihong Yang and Elliot A. Stein

21 Functional Neural Predictors of Addiction Outcomes 503
Elliot T. Berkman

Index 527