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The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine
Frye, Berk
Editore
Springer
Anno
2019
Pagine
394
ISBN
9789811053108
170,00 €

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Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable.

Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation.

The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

  • History of N-Acetylcysteine

    Herzenberg, Leonore A.

    Pages 3-15

  • Neurotransmitter Systems: Glutamate

    Foster Olive, M. (et al.)

    Pages 19-28

  • Neurotransmitter Systems: Dopamine

    Kumar, Nihit

    Pages 29-51

  • Oxidative Stress in Psychiatric Disorders

    Fung, Lawrence (et al.)

    Pages 53-72

  • Mitochondrial Metabolism

    Rose, Shannon (et al.)

    Pages 73-103

  • Apoptosis

    Bennuri, Sirish C. (et al.)

    Pages 105-121

  • Inflammation

    Tirouvanziam, Rabindra

    Pages 123-135

  • Clinical Trials on N-Acetylcysteine

    Frye, Richard Eugene

    Pages 139-146

  • N-Acetylcysteine in the Poisoned Patient

    Chiew, Angela L. (et al.)

    Pages 147-168

  • The Use of N-Acetylcysteine as a Chelator for Metal Toxicity

    Rossignol, Daniel A.

    Pages 169-179

  • Application of N-Acetylcysteine in Neurological Disorders

    Shahripour, Reza Bavrsad (et al.)

    Pages 181-202

  • Application of N-Acetylcysteine in Psychiatric Disorders

    Slattery, John (et al.)

    Pages 203-218

  • Clinical Treatment of Addictive Disorders with N-Acetylcysteine

    Powell, Gregory (et al.)

    Pages 219-233

  • The Clinical Use of N-Acetylcysteine for the Treatment and Protection Against Renal Disease

    Frye, Richard Eugene

    Pages 235-253

  • Application of N-Acetylcysteine in Pulmonary Disorders

    Conrad, Carol

    Pages 255-276

  • The Clinical Use of N-Acetylcysteine in Cardiology

    Marenco, John P. (et al.)

    Pages 277-287

  • The Clinical Use of N-Acetylcysteine in Gastrointestinal Disorders

    Frye, Richard Eugene

    Pages 289-299

  • The Clinical Use of N-Acetylcysteine in Other Medical Disorders

    Frye, Richard Eugene

    Pages 301-330

  • The Physiological Effects of N-Acetylcysteine in Clinical Studies

    Frye, Richard Eugene

    Pages 331-348

  • Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease

    Ghezzi, Pietro (et al.)

    Pages 349-386

  • Pharmacology, Formulations, and Adverse Effects

    Frye, Richard Eugene (et al.)

    Pages 387-394

 

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