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The Lithium Ion
Pages 3-23
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
The Science and Practice of Lithium Therapy
Anno
2017
Pagine
342
ISBN
9783319459219
157,00 €
DA SCONTARE
This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects. Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide, and those that are recipients of lithium therapy.
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The Pharmacokinetics of Lithium
Pages 25-53
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Lithium: Neurotransmission and Cellular Mechanism Pathways Underlying Neuroprogression in Bipolar Disorder
Pages 55-75
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The Effect of Lithium on Gene Expression Modulation
Pages 77-96
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Neuroimaging and Lithium
Pages 97-109
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Lithium and Circadian Rhythms
Pages 111-124
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Clinical Predictors Relevant to Lithium Response
Pages 125-140
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Lithium Response Variability (Pharmacogenomics Studies)
Pages 141-155
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Lithium Response Variability: New Avenues and Hypotheses
Pages 157-178
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The History of Lithium in Medicine and Psychiatry
Pages 181-188
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Recommendations in International Clinical Practice Guidelines for Lithium Therapy of Bipolar Disorder
Pages 189-209
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Lithium in Acute and Maintenance Treatment of Bipolar Disorders
Pages 211-222
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Lithium and Suicide Prevention
Pages 223-240
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Lithium Discontinuation and Reintroduction
Pages 241-247
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Short- and Midterm Side Effects of Lithium Therapy
Pages 249-264
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Lithium and Renal Failure
Pages 265-276
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Lithium Toxicity: Clinical Presentations and Management
Pages 277-292
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Lithium and Pregnancy
Pages 293-301
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Lithium in Children and Adolescents
Pages 303-314
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Lithium Use in Elderly Patients with Bipolar Disorder
Pages 315-321
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Lithium in the Twenty-First Century
Pages 323-327
