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Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
Pages 1-24
This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
Pages 1-24
Essential Concepts and Techniques in Molecular Biology
Pages 25-42
Cancer Genomics
Pages 43-63
Cancer Cytogenetics
Pages 65-82
Epigenetic Basis of Human Cancer
Pages 83-102
Cancer Proteomics
Pages 103-119
An Overview of Cancer Genes
Pages 121-142
Oncogenes and the Initiation and Maintenance of Tumorigenesis
Pages 143-157
Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors
Pages 159-182
Senescence, Apoptosis, and Cancer
Pages 183-196
Novel Cancer Therapies Targeting Angiogenesis
Pages 197-202
Beyond the Primary Tumor: Progression, Invasion, and Metastasis
Pages 203-216
Simple Sequence Mutations
Pages 217-230
Single Nucleotide Polymorphisms and Cancer Susceptibility
Pages 231-239
Chromosomes and Chromosomal Instability in Human Cancer
Pages 241-262
Epigenetic Mechanisms in Cancer Development
Pages 263-275
MicroRNAs and Cancer
Pages 277-286
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Pages 287-295
Viral Mechanisms in Human Carcinogenesis
Pages 297-306
Hormonal Carcinogenesis: The Role of Estrogens
Pages 307-322
Sporadic Cancers
Pages 323-334
Hereditary Cancer
Pages 335-353
Retinoblastoma: Clinical and Molecular Perspectives
Pages 355-361
Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light
Pages 363-380
Hereditary Colorectal Cancer
Pages 381-400
Hereditary Breast and Ovarian Cancer
Pages 401-421
The Molecular Basis of Prostate Carcinogenesis
Pages 423-445
Molecular Basis of Lung Carcinogenesis
Pages 447-496
Molecular Basis of Skin Carcinogenesis
Pages 497-503
Molecular Biology of Leukemias
Pages 505-559
Molecular Mechanisms in Non-Hodgkin Lymphoma
Pages 561-587
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
Pages 589-601
Ovarian Cancer
Pages 603-621
Molecular Pathology of Bone and Soft Tissue Tumors
Pages 623-655
Molecular Biology of Human Brain Tumors
Pages 657-694
Cancer Drug Discovery and Anticancer Drug Development
Pages 695-707
Biological Principles and Clinical Application of EGFR Inhibitors in Cancer
Pages 709-726
Targeting Oncoproteins for Molecular Cancer Therapy
Pages 727-756
Therapeutic Agents That Inhibit Angiogenesis
Pages 757-769
Small Molecule Inhibitors
Pages 771-795
Molecular Detection and Diagnosis of Cancer
Pages 797-809
Gene Therapy in the Treatment of Human Cancer
Pages 811-841
Personalized Medicine for the Treatment of Human Cancer
Pages 843-855
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