The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Home

/

Specialità

/

Endocrinologia

/

The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Cushing’s Syndrome and Beyond

Editore

Springer

Anno

2017

Pagine

327

ISBN

9783319459486

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

Dettagli Indice Recensioni (0)

Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.

Glucocorticoid Regulation of Body Composition and Metabolism

Opata, Alexandria Atuahene (et al.)

Pages 3-26
Glucocorticoid Regulation of Neurocognitive and Neuropsychiatric Function

Pereira, Alberto M. (et al.)

Pages 27-41
Glucocorticoids: Inflammation and Immunity

Petrillo, Maria G. (et al.)

Pages 43-63
Molecular Pathogenesis of Primary Adrenal Cushing’s Syndrome

Ghorayeb, Nada (et al.)

Pages 67-92
Pathogenesis and Treatment of Aggressive Corticotroph Pituitary Tumors

Shen, Yang (et al.)

Pages 93-110

Neoplastic/Pathological and Nonneoplastic/Physiological Hypercortisolism: Cushing Versus Pseudo-Cushing Syndromes

Findling, James W. (et al.)

Pages 111-136
Imaging Strategies for Localization of ACTH-Secreting Tumors

Nieman, Lynnette K. (et al.)

Pages 137-148
Surgical Treatment of Cushing’s Disease

Zarzour, Hekmat (et al.)

Pages 149-164
Medical Therapies in Cushing’s Syndrome

Tritos, Nicholas A. (et al.)

Pages 165-179
Mild Adrenal Cortisol Excess

Turcu, Adina F. (et al.)

Pages 181-197
Long-Term Effects of Prior Cushing’s Syndrome

Aulinas, Anna (et al.)

Pages 199-224
Cushing’s Disease, Refining the Definition of Remission and Recurrence

Ciporen, Jeremy N. (et al.)

Pages 225-252
Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

Nicolaides, Nicolas C. (et al.)

Pages 255-269
Cortisol Metabolism as a Regulator of the Tissue-Specific Glucocorticoid Action

Sbardella, Emilia (et al.)

Pages 271-301
Obesity and Metabolic Syndrome: A Phenotype of Mild Long-Term Hypercortisolism?

Wester, Vincent L. (et al.)

Pages 303-313