Section 1: Universal definition of heart failure
1.1:Universal definition of heart failure, Andrew JS Coats, Biykem Bozkurt and Petar M. Seferovic
Section 2: Epidemiology of heart failure
2.1:Epidemiology of heart failure, Amy Groenewegen, Ivan Milinkovi?, Arno W Hoes, Arend Mosterd, Frans H Rutten
Section 3: Etiology of heart failure
3.1:Coronary artery disease, (Rocco Antonio Montone, Maurizio Volterrani, Jian Zhang and Filippo Crea
3.2:Hypertension, Athanasios Manolis and Yuri Lopatin
3.3:Valvular heart disease, Ana Pardo Sanz, Ivan Milinkovic and Josep Zamorano
3.4.1:Genetic basis of cardiomyopathies, Thomas Thum, Stephane Heymans, and Johannes Backs
3.4.2:Dilated and hypokinetic non-dilated cardiomyopathy, Petar M.Seferovic, Biykem Bozkurt, and Marija Polovina
3.4.3:Hypertrophic cardiomyopathy, Perry Elliott, Michel Noutsias and Aris Anastasakis
3.4.4:Restrictive cardiomyopathy, Claudio Rapezzi, Alberto Aimo, Ales Linhart, and Andre Keren
3.4.5:Arrhythmogenic right ventricular cardiomyopathy, Cristina Basso, Hugh Calkins and Domenico Corrado
3.4.6:Peripartum cardiomyopathy, Karen Sliwa and Johann Bauersachs
3.4.7:Takotsubo cardiomyopathy, Jelena Templin-Ghadri, Michael Würdinger, Johann Bauersachs, and Christian Templin
3.5:Myocarditis and pericarditis, Stephane Heymans, Arsen Risti?, Yehuda Adler, and Massimo Imazio
3.6:Congenital heart disease, Werner Budts and Jolien Roos-Hesselink
3.7:Endocrine and metabolic disorders, Martin Huelsmann, Jelena Seferovic and Francesco Cosentino
3.8:Obesity, Lina Badimon, Stefan Anker and Stephan von Haehling
3.9:Cancer and cancer therapy, Alexander Lyon, Dimitrios Farmakis, Daniela Cardinale and Teresa Lopez Fernandez
3.10:Toxins (e.g. alcohol etc.) and infections, Antonello Gavazzi, Maria Nunes, and Fausto Pinto
Section 4: Prevention of heart failure
4.1:Prevention of heart failure, Massimo Piepoli, Maria Benedetta Matrone, Paul Dendale, and Shelley Zieroth
Section 5: Pathophysiology of heart failure
5.1:Molecular and cellular mechanisms, (Junjie Xiao, Thomas Thum, Gianluigi Condorelli and Johannes Backs
5.2:Alterations in myocardial metabolism, Edoardo Bertero and Chistoph Maack
5.3:Ventricular remodelling, Javier Diez Martinez and Hans-Peter Brunner La Rocca
5.4:Neurohormonal activation, Antoni Bayes Gennis and Faiez Zannad
5.5:Immune-mediated mechanisms, Urlich Hofmann, Stefan Frantz and Nikolaos Frangogiannis
5.6:Inflammation, oxidative stress and endothelial dysfunction, Stephane Heymans
5.7:Alterations in peripheral circulation and renal function, Alterations in peripheral circulation and renal function (
5.8:Systemic adaptations in metabolism and nutritive status, (Stephan von Haehling and Wolfram Doehner
Section 6: Clinical phenotypes of chronic heart failure
6.1:HFrEF, Thomas Luscher, Petar Seferovic, and Brian Halliday
6.2:HFmrEF, Adrian Voors, Brenda Moura, Lars Lund and Carolyn Lam
6.3:HFpEF, Rudolf De Boer, Burkert Pieske, and Barry Borlaug
6.4:Right heart failure, Thomas Luscher, Thomas M. Gorter, Susanna Price, Michael Gatzoulis and Anneline Te Riele
Section 7: Chronic heart failure: diagnostic and prognostic assessment
7.1:Clinical assessment, Michel Komajda, Piotr Ponikowski, and Evgeny Shlyakhto
7.2:Biomarkers in diagnostic and prognostic assessment, Rudolf de Boer, Antioni Bayes Genis and James Januzzi
7.3:Echocardiography, Philippe Debonnaire, Victoria Delgado, Thor Edvardsen, Bogdan Popescu, and Jeroen Bax
7.4:Nuclear medicine, Danilo Neglia and Alessia Gimelli
7.5:Cardiac computed tomography, Stephan Achenbach and Amina Rakisheva
7.6:Cardiac magnetic resonance, Anna Baritussio, Noor Sharrack, Sven Plein, and Chiara Bucciarelli-Bucci
7.7:Cardiopulmonary exercise, Luca Moderato, Davide Lazzeroni, Stamatis Adamopoulos, Alain Cohen-Solal and Massimo Piepoli
7.8:Cardiac catheterization, invasive imaging and haemodynamic assessment, Christian Hamm, Brigit Assmus and Veselin Mitrovic
Section 8: Chronic heart failure: pharmacological management
8.1:Angiotensin converting enzyme inhibitors, Roberto Ferrari, Gabriele Guardigli, and Biykem Bozkurt
8.2:Angiotensin I receptor blockers, Ileana L. Pina and Magdy Abdelhamid
8.3:ARNI, Petar M. Seferovic, Michele Senni, Marija Polovina and Andrew JS Coats
8.4:Beta-blockers, Daniela Tomasoni, Marianna Adamo, Hiroyuki Tsutsui, and Marco Metra
8.5:Mineralocorticoid receptor agonists, Bertram Pitt, João Pedro Ferreira and Faiez Zannad
8.6:Ivabradine, Michael Bohm and Michel Komajda
8.7:Vasodilators, Eftihia Polyzogopoulou, Maria Nikolaou, John Parissis and Alexandre Mebazaa
8.8:Digitalis glycosides, Udo Bavendiek and Johann Bauersachs
8.9:Diuretics, Jeroen Dauw, Stephen Gottlieb and Wifried Mullens
8.10:Inotropes and inodilators, Jan Biegus, Piotr Ponikowski, and Christoph Maack
8.11:SGLT2 inhibitors, Petar M. Seferovic, Francesco Cosentino, Giuseppe Rosano and James Januzzi
8.12:Ancillary pharmacological treatment options, Stefan Agewall, Isabelle van Gelder, and Irene Savelieva
8.13:New and emerging therapies, Giuseppe Rosano, Gerasimos Filippatos, and Randall Starling
Section 9: Chronic heart failure: non-pharmacological management
9.1:Implantable cardioverter defibrillator, Gianluigi Savarese, Cecilia Linde and Kenneth Dickstein
9.2:Cardiac resynchronization therapy, Pieter Martens, Eva Goncalvesova, and Wilfried Mullens
9.3:Cardiac surgery, Felix Schoenrat, Franz-Josef Neumann, Miguel Sousa Uva and Volkmar Falk
9.4:Valve interventions, Stefan Orwat, Stefan Anker and Helmut Baumgartner
9.5:Ancillary procedures, Andrew JS Coats, Piotr P Ponikowski, Maria-Rosa Costanzo and William T. Abraham
9.6:Cardiac rehabilitation, Maurizio Volterrani, Alain Cohen-Solal, Stamatis Adamopulos, Dimitris Miliopoulos, Ferdinando Iellamo, and Massimo Piepoli
Section 10: Acute heart failure
10.1:Acute heart failure: diagnostic and prognostic assessment, Ovidiu Chioncel, Gerasimos Filippatos, Alexandre Mebazaa, Veli-Pekka Harjola, and Josep Masip
10.2:Acute heart failure: management, Katerina Fountoulaki, John Parissis, Sean Collins, Mehmet Birhan Yilmaz, and Alexandre Mebazaa
Section 11: Advanced heart failure
11.1:Advanced heart failure: assessment, Tuvia Ben Gal, Mariell Jessup, and Maria-Rosa Costanzo
11.2:Advanced heart failure: management, Daniela Tomasoni, Marianna Adamo, and Marco Metra
11.3:Mechanical circulatory support, Mandeep Mehra and Finn Gustafsson
11.4:Heart transplantation, Davor Milicic, Mandeep Mehra, and Randall Starling
11.5:Palliative care and end-of-life management, Tiny Jaarsma, Donna Fitzsimons, Lisa Hjelmfors, Loreena Hill, Ekaterini Lambrinou, and Anna Strömberg
Section 12: Comorbidities and clinical conditions
12.1:Chronic kidney disease: Clinical Aspects of Chronic Kidney Disease in Heart Failure, Pieter Martens and Hans-Peter Brunner-La Rocca
12.2:Dyskalaemia, Javed Butler, Wilfried Mullens and Kevin Damman and João Pedro Ferreira
12.3:Chronic lung disease, Josep Masip, Karina Portillo and Mattia Arrigo
12.4:Ventilatory Abnormalities and Sleep Disordered Breathing, Piergiuseppe Agostoni, Elisabetta Salvioni, Maria Rosa Costanzo, and Andrew JS Coats
12.5:Pulmonary hypertension, Irene M. Lang and Stephan Rosenkranz
12.6:Cardiac rhythm disorders, Silvia Priori, Alessandro Trancuccio, Alessia Chiara Latini, Carlo Arnò, Deni Kukavica, and Andrea Mazzanti
12.7:Management of atrial fibrillation in heart failure, Paulus Kirchhof, Andreas Metzner, Ruben Schleberger and Douglas Packer
12.8:Diabetes, metabolic syndrome and endocrine disorders, Giuseppe Rosano, Javed Butler, Petar M. Seferovi?, Jelena Seferovic and Francesco Cosentino
12.9:Systemic immune medicated diseases, Giacomo De Luca, Luca Moroni, Alessandro Tomelleri, R Marcolongo, Lorenzo Dagna, Alida LP Caforio, and Marco Matucci-Cerinic
12.10:Liver and gut dysfunction, Yuri Lopatin and Gianluigi Savarese
12.11:Anaemia and iron deficiency, Ewa Jankowska, Piotr Ponikowski, and Stefan Anker
12.12:Depression and cognitive impairment, Wolfram Doehner, Cristiana Vitale, and Mehmet Birhan Yilmaz
12.13:Cancer, Alexander Lyon, Dimitrios Farmakis, Rudolf de Boer, and Yuri Belenkov
12.14:Pregnancy, Johann Bauersachs, Denise Hilfiker-Kleiner and Karen Sliwa
12.15:Frailty, Ewa Jankowska, Cristiana Vitale and Dong-Ju Choi
Section 13: Self-care and patient education
13.1:Self-care and patient education, Tiny Jaarsma, Loreena Hill, Ekaterini Lambrinou, Anna Stromberg, and Tina Hansen
Section 14: Multidisciplinary approach to heart failure management
14.1:Multidisciplinary approach to heart failure management, Loreena Hill, Friedrich Koehler, Tiny Jaarsma, Marija Polovina, Katherine McCreary, and Andrew JS Coats
Section 15: Clinical trial design and interpretation
15.1:Clinical trial design and interpretation, Gianluigi Savarese, Marija Polovina and Gerasimos Filippatos
Section 16: Digital health in heart failure
16.1:Digital health in heart failure, Arvind Singhal and Martin Cowie
Section 17: Big data in heart failure
17.1:Big data in heart failure, Mamas Mamas and Dipak Kotecha
Section 18: Telemedicine and remote monitoring
18.1:Telemedicine and remote monitoring, Tarek Bekfani, Friedrich Koehler and William T. Abraham