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Anatomy and Pharmacology of Vessels
Pages 3-11
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons.
This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease).
The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Anatomy and Pharmacology of Vessels
Pages 3-11
Pages 13-22
Cell Biology of Vessels
Pages 23-30
Stem Cell Biology and the Cardiovascular System
Pages 31-44
The Lymphatic System
Pages 45-57
Imaging the Vascular Wall: From Microscope to Virtual Reality
Pages 59-66
Clinical Cardiovascular Imaging
Pages 67-79
Vascular Signaling
Pages 83-91
Vasoactive Peptides: Renin-Angiotensin-Aldosterone System
Pages 93-101
Aldosterone
Pages 103-115
Nitric Oxide
Pages 117-126
Reactive Oxygen Species
Pages 127-136
TGF-β in Vascular Pathobiology
Pages 137-148
MicroRNA and LncRNA in the Vascular System
Pages 149-158
Microparticles and Exosomes in Cell-Cell Communication
Pages 159-168
Genomics of Hypertension
Pages 171-181
Endothelial Dysfunction
Pages 183-192
Vascular Remodeling
Pages 193-201
Arterial Stiffness
Pages 203-213
Atherosclerosis
Pages 215-228
Inflammation and Immunity in Vascular Diseases
Pages 229-238
Diagnostic and Therapeutic Targeting of Inflammation
Pages 239-246
Perivascular Adipose Tissue
Pages 247-258
Vascular Biology of Cancer Chemotherapeutic Drugs
Pages 259-268
Coronary Microvascular Disease
Pages 269-273
Cerebral Small Vessel Disease and Vascular Cognitive Impairment: Preclinical Aspects
Pages 275-285
Ethnicity and Cardiovascular Disease
Pages 287-295
Epidemiology of Vascular Diseases
Pages 299-306
Healthy Vascular Ageing and Early Vascular Ageing
Pages 307-318
Biomarkers of Cardiovascular Disease
Pages 319-330
Hypertension
Pages 331-341
Diabetic Retinopathy
Pages 343-354
Ischaemic Heart Disease
Pages 355-363
Pre-eclampsia
Pages 365-372
Stable Coronary Syndromes
Pages 373-381
Heart Failure with Reduced Ejection Fraction
Pages 383-395
Heart Failure with Preserved Ejection Fraction
Pages 397-408
Renal Disease
Pages 409-417
Obesity
Pages 419-427
Diabetes and Vascular Disease
Pages 429-437
Pulmonary Hypertension
Pages 439-447
Cerebral Small Vessel Disease and Vascular Cognitive Impairment
Pages 449-459
Stroke
Pages 461-472
Peripheral Vascular Disease
Pages 473-483
Vascular Malformations and Tumours
Pages 485-499
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