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per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Targeted Therapies for Solid Tumors
A Handbook for Moving Toward New Frontiers in Cancer Treatment
Russo, Rosell, Rolfo
Editore
Springer
Anno
2015
Pagine
269
ISBN
9781493920464
100,00 €
Description
This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature.
Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
Table of Contents
1 Introduction 1
Antonio Russo, Christian Rolfo and Rafael Rosell
2 Oncogene Addiction in Solid Tumors 3
Stefano Caruso, Daniele Fanale and Viviana Bazan
3 Pharmacology and Clinical Development of New Molecularly Targeted Agents 9
Elisa Giovannetti and Elena Galvani
4 Biomarkers as Prognostic, Predictive,
and Surrogate Endpoints 31
Francesco Passiglia, Giuseppe Cicero, Marta Castiglia
and Viviana
Bazan
5 Evaluation of Response in Malignant Tumors Treated
with Targeted Agents 43
Giuseppe Lo Re, Federica Vernuccio, Maria Cristina Galfano,
Federico Midiri and Massimo Midiri
6 Targeted Therapies for HER2-positive Breast Cancer 57
Maria Vittoria Dieci, Valentina Guarneri, Carlo Alberto Giorgi
and Pierfranco Conte
7 Role of Poly ADP-Ribose Polymerase (PARP) Inhibitors
in Triple-Negative Breast Cancer (TNBC) 73
Enrico Ricevuto, Katia Cannita, Gemma Bruera,
Eleonora Palluzzi, Valentina Cocciolone, Corrado Ficorella and Antonio Russo
8 Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck 81
Pol Specenier
9 Targeted Therapies for Non-Small Cell Lung Cancer 89
Antonio Russo, Christian Rolfo, Francesco Passiglia and Rafael Rosell
10 Targeted Therapies for Gastric Cancer ....................................... 103
Nishi Kothari, Khaldoun Almhanna
11 Targeted Therapies for Pancreatic Cancer .................................. 127
Luis León, Enrique Grande and Luis Antón-Aparicio
12 Targeted Therapies in Hepatocellular Carcinoma ...................... 137
Fabrizio Bronte, Enrico Bronte, Giuseppe Bronte
and Vito Di Marco
13 Targeted Therapies for Colorectal Cancer .................................. 147
Antonio Russo, Antonio Galvano, Giuseppe Bronte
and Marc Peeters
14 Targeted Therapy in Gastrointestinal Stromal Tumors ............. 163
Piotr Rutkowski, Joanna Przybył, Agnieszka Wozniak
and Giuseppe Badalamenti
15 Targeted Therapies in Kidney Cancer ......................................... 197
Amparo Sánchez Gastaldo, Aránzazu González del Alba
and Ignacio
Durán
16 Targeted Therapies in Melanoma ................................................. 211
Daniele Fanale, Giuseppe Bronte and Antonio Russo
17 Targeted Therapies for Prostate Cancer ...................................... 229
Aránzazu González del Alba, Luis León, Cristina Suárez
and Maria José Méndez
18 Targeted Therapies for Bone Metastases ..................................... 249
Daniele Santini, Chiara Spoto, Vito Longo, Michele Iuliani,
Alice Zoccoli,
Salvatore Intagliata, Francesco Pantano
and Franco Silvestris
Index ...................................................................................................... 267
