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Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
T-Cell Lymphomas
Foss
Editore
Elsevier
Anno
2013
Pagine
340
ISBN
9781627031707
170,00 €
- Comprehensive volume examines the clinical and biological aspects of the T-cell lymphomas
- Addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies
- Outstanding resource for hematologists and oncologists
- Provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies
The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells.
This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
Contents
1 Histopathology and Classification of T-Cell Lymphomas ........ 1
Claudiu V. Cotta and Eric D. Hsi
2 Epidemiology and Prognosis of T-Cell Lymphoma ................... 25
Sophia S. Wang and Julie M. Vose
3 Molecular Profiling and Prognosis in T-Cell
Lymphomas .................................................................................. 41
Pier Paolo Piccaluga and Stefano Aldo Pileri
4 Molecular and Clinical Aspects of Angioimmunoblastic
T-Cell Lymphoma ........................................................................ 57
Laurence de Leval, Francine Foss, and Philippe Gaulard
5 Primary Cutaneous and Systemic CD30+ T-cell
Lymphoproliferative Disorders .................................................. 71
Marshall E. Kadin and Francine Foss
6 NK-Cell Neoplasms ...................................................................... 87
Motoko Yamaguchi and Kensei Tobinai
7 Rare Subtypes of Extranodal T-Cell Lymphoma ...................... 105
Frederick Lansigan, S. David Hudnall, and Francine Foss
8 HTLV-1-Associated T-cell Diseases ............................................ 113
Kunihiro Tsukasaki and Kensei Tobinai
9 The T-Cell Leukaemias ................................................................ 137
Elisabeth Grey-Davies and Claire Dearden
10 Cutaneous T-Cell Lymphomas .................................................... 155
Farah Rukhsana Abdulla, Madeleine Duvic,
and Youn H. Kim
11 T-Cell Malignancies in Children and Adolescents:
State of the Clinical and Biological Science ............................... 179
Nader Kim El-Mallawany, Pieter Van Vlierberghe,
Adolfo A. Ferrando, Megan S. Lim, and Mitchell S. Cairo
xii Contents
12 Approaches for First-Line Therapy of Peripheral
T-Cell Lymphoma ........................................................................ 217
David Sibon, Christian Gisselbrecht, and Francine Foss
13 Autologous and Allogeneic Stem Cell Transplantation
for T-Cell Lymphomas ................................................................. 229
José Rodríguez and Paolo Corradini
14 Monoclonal Antibodies (mAb) in the Therapy
of T-Cell Lymphomas ..................................................................... 243
Lapo Alinari, Pierluigi Porcu, and Bertrand Coiffier
15 Nucleoside Analogs in the Therapy of T-Cell
Malignancies ................................................................................. 263
Varsha Gandhi and Pier Luigi Zinzani
16 Current Epigenetic Therapy for T-Cell Lymphoma ................. 279
Michael Dickinson, Chan Cheah, and H. Miles Prince
17 Novel Therapies for T-cell Lymphomas ..................................... 297
Christiane Querfeld and Steven T. Rosen
18 Immunotherapy for Cutaneous T-Cell Lymphoma .................. 307
Badri Modi, Francine Foss, Richard L. Edelson,
and Michael Girardi
19 Syndromes and Clinical Management Issues
Associated with T-Cell Lymphomas ........................................... 317
Merry Jennifer Markham and Nam H. Dang
Index ...................................................................................................... 333
