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Vascular-Mediated Mechanisms and SRS/SBRT
Pages 3-13
This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients.
Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.
Vascular-Mediated Mechanisms and SRS/SBRT
Pages 3-13
Radio-Immunology of Ablative Radiation
Pages 15-29
Rationale for Fractionated SRS and Single SRS Session Approaches
Pages 31-40
Physics of Radiosurgery
Pages 43-54
Leksell Gamma Knife Radiosurgery
Pages 55-65
CyberKnife Robotic Stereotactic Radiosurgery
Pages 67-76
Linear Accelerator-Based Radiosurgery: Technique
Pages 77-82
Fractionated Radiosurgery
Pages 83-90
Charged-Particle Proton Radiosurgery
Pages 91-101
Stereotactic Radiosurgery for Brain Metastases
Pages 105-111
Stereotactic Radiosurgery for Pituitary Adenoma
Pages 113-121
Stereotactic Radiosurgery for Meningioma
Pages 123-129
Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations
Pages 131-140
Radiosurgical Management of Trigeminal Neuralgia
Pages 141-150
Radiosurgery for Vestibular Schwannomas
Pages 151-161
Stereotactic Radiosurgery for Glial Tumors
Pages 163-171
Physics of Stereotactic Body Radiotherapy
Pages 175-183
Immobilization for SBRT: A Crucial Prerequisite Toward Accurate Treatment
Pages 185-193
Motion Management in Stereotactic Body Radiation Therapy
Pages 195-215
Charged Particle Stereotactic Body Radiation Therapy
Pages 217-233
Stereotactic Body Radiation Therapy (SBRT) for Primary Lung Cancer
Pages 237-246
Stereotactic Body Radiation Therapy (SBRT) for Lung Metastases
Pages 247-264
Stereotactic Body Radiation Therapy (SBRT) for Spinal Tumors
Pages 265-276
Stereotactic Body Radiation Therapy for Gastrointestinal Cancers
Pages 277-288
SAbR for Primary Prostate Cancer
Pages 289-305
Stereotactic Ablative Radiotherapy (SAbR) for Primary Renal Cell Carcinoma
Pages 307-317
Head and Neck Stereotactic Body Radiation Therapy
Pages 319-329
Pages 331-343
Patient Selection in SBRT and SRS
Pages 347-357
SRS and SBRT Complications and Management
Pages 359-372
SRS and SBRT Integration with Supportive Care
Pages 373-379
Targeted Agents and Immunotherapy
Pages 381-388
Diagnostic Imaging Advances
Pages 389-413
Comparative Effectiveness of SBRT
Pages 415-424
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