Stem Cell-Based Therapy for Lung Disease

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Stem Cell-Based Therapy for Lung Disease

Editore

Springer

Anno

2020

Pagine

259

ISBN

9783030294021

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This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies.

Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung.

The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application.

This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

Chronic Lung Pathologies That Require Repair and Regeneration

Pages 1-12

Hilster, Roderick (et al.)
Stem/Progenitor Cell Populations Resident in the Lung and the Role of Stromal Support in Their Maintenance and Differentiation

Pages 15-34

Heijink, Irene H. (et al.)
Comparison of the Regenerative Potential for Lung Tissue of Mesenchymal Stromal Cells from Different Sources/Locations Within the Body

Pages 35-55

Enes, Sara Rolandsson (et al.)
The Potential of Factors Released from Mesenchymal Stromal Cells as Therapeutic Agents in the Lung

Pages 57-70

Cruz, Fernanda Ferreira (et al.)
Preclinical Evidence for the Role of Stem/Stromal Cells in COPD

Pages 73-96

Bölükbas, Deniz A. (et al.)

Clinical Application of Stem/Stromal Cells in COPD

Pages 97-118

Enes, Sara Rolandsson (et al.)
Stem Cell Based Therapy for Lung Disease Preclinical evidence for the role of stem/stromal cells Clinical application of stem/stromal cells in lung fibrosis

Pages 119-130

Patete, Carissa L. (et al.)
Paving the Road for Mesenchymal Stem Cell-Derived Exosome Therapy in Bronchopulmonary Dysplasia and Pulmonary Hypertension

Pages 131-152

Yeung, Vincent (et al.)
CRISPR/Cas9 Editing in Induced Pluripotent Stem Cells: A Way Forward for Treating Cystic Fibrosis?

Pages 153-178

Quiroz, Erik J. (et al.)
Clinical Application of Stem/Stromal Cells in Cystic Fibrosis

Pages 179-198

Leung, Steven T. (et al.)
Preclinical Evidence for the Role of Stem/Stromal Cells in Targeting ARDS

Pages 199-217

Cruz, Tamara (et al.)
The Safety and Efficiency of Addressing ARDS Using Stem Cell Therapies in Clinical Trials

Pages 219-238

Rezoagli, Emanuele (et al.)
Stem Cell Delivery Systems and Devices - Spraying

Pages 241-253

Kim, Sally Yunsun (et al.)
Challenges and Opportunities for the Future of Stem Cell Therapy for Lung Diseases

Pages 257-259

Heijink, Irene H. (et al.)