CONTENTS
Contributor List vi
Foreword xx
Preface xxi
PART ONE ■ CRITICAL CARE INTEGRATION
Section I ■ Introduction to the Practice of Pediatric Critical Care . . . . . . . . 3
Section Editor: Niranjan “Tex” Kissoon
Chapter 1 Pediatric Intensive Care: A Global Perspective . . . . . . . . . . . . . . . . . .3
Trevor Duke, Niranjan “Tex” Kissoon, and Mark C. Rogers
Chapter 2 Impact of Pediatric Critical Care on the Family, Community, and Society . . . . . . . . 11
Hilary Schreiber, Jos M. Latour, Khaliah A. Johnson, Wynne E. Morrison, Roxanne E. Kirsch,
Andrew J. Helmers, Carlie N. Myers, Melissa Jerdonek Sacco, Matt Norvell, Lewis H. Romer, and Alison H. Miles
Section II ■ Professionalism, Leadership, and Systems-Based Practice . . . . . .24
Section Editors: Joy Deanna Howell and Z. Leah Harris
Chapter 3 Diversity,Equity,andInclusion . . . . . . . . . . . . . . . . . . . . . . . 24
Joy Deanna Howell and Z. Leah Harris
Chapter 4 Professionalism and Leadership in Pediatric Critical Care . . . . . . . . . . . . . .27
Alice D. Ackerman and Vinay M. Nadkarni
Chapter 5 Simulation Training and Team Dynamics . . . . . . . . . . . . . . . . . . . .34
David J. Grant, Rakshay Shetty, Michael A. Rosen, Elizabeth A. Hunt, and Nicole A. Shilkofski
Chapter 6 Pediatric Intensive Care Unit Organization and Physical Design . . . . . . . . . . . 48
Michele Moss and Shari Simone
Chapter 7 Practice Management: The Business of Pediatric Critical Care . . . . . . . . . . . .63
Meredith G. van der Velden and Jeffrey P. Burns
Chapter 8 Research Design and Statistical Analysis . . . . . . . . . . . . . . . . . . . 70
Anne-Marie Guerguerian, Elizabeth A. Hunt, and Wynne E. Morrison
Chapter 9 Evidence-BasedMedicine.........................91
Kathleen L. Meert, Barry P. Markovitz, Amarilis A. Martin, Andy Prout, and Asavari Kamerkar
Chapter 10 Quality Improvement, Patient Safety, and Medical Error . . . . . . . . . . . . . 101
Vicki L. Montgomery and Melissa B. Porter
Section III ■ Information Management . . . . . . . . . . . . . . . . .112
Section Editor: Randall C. Wetzel
Chapter 11 Severity-of-Illness Measurement in Pediatric Critical Care Medicine: Foundations, Principles,
Outcomes,andApplications . . . . . . . . . . . . . . . . . . . . . . . 112
Anthony D. Slonim, James P. Marcin, and Murray M. Pollack
xxiii

xxiv
Contents
Clinical Informatics and Communication Technology in Pediatric Critical Care . . . . . .121
L. Nelson Sanchez-Pinto, Maya Dewan, Adam Dziorny, and Sapna R. Kudchadkar
Chapter 12
Chapter 13 Learning From Patient Data: Data Science for Critically Ill Children . . . . . . . . . .134
Melissa D. Aczon, David Ledbetter, and Randall C. Wetzel
Section IV ■ Ethical and Palliative Concerns in the Care of the Critically Ill . . . .147
Section Editors: Jeffrey P. Burns and Sapna R. Kudchadkar
Chapter 14 Palliative and End-of-Life Care in the Pediatric Intensive Care Unit . . . . . . . . . .147
Wynne E. Morrison, Amarilis A. Martin, Patricia Miranda do Lago, Jefferson Pedro Piva, and
Kathleen L. Meert
Chapter 15 PainandSedationManagement . . . . . . . . . . . . . . . . . . . . . .156
Sapna R. Kudchadkar, E. Alexis Bragg, Erwin Ista, and Myron Yaster
Chapter 16 Ethics in the Pediatric Intensive Care Unit . . . . . . . . . . . . . . . . . . .194
Erin Talati Paquette, Andrew J. Helmers, and Roxanne E. Kirsch
Chapter 17 OrganDonation............................207
Kristen Nelson McMillan, Travis J. Matics, Sally H. Vitali, and Thomas A. Nakagawa
Chapter 18 Early Mobilization and Acute Rehabilitation in Critically Ill Children . . . . . . . . . 228
Sapna R. Kudchadkar, Anton Dietzen, and Melissa K. Trovato
Section V ■ Basic Science Concepts of Pediatric Critical Care . . . . . . . . .242
Section Editor: Sujatha Kannan
Chapter 19 OmicsandCriticalCare.........................242
Dennis W. Simon, Kate F. Kernan, Tamil Selvan Anthonymuthu, and Hülya Bayir
Chapter 20 Innate Immunity and Inflammation . . . . . . . . . . . . . . . . . . . . . 258
Samuel Zachary Davila and Jessica Germond Moreland
Chapter 21 CellularAdaptationstoStress . . . . . . . . . . . . . . . . . . . . . . .271
Stephen W. Standage, Derek S. Wheeler, and Hector R. Wong
Chapter 22 Shock, Ischemia, and Reperfusion Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .286
Basilia Zingarelli
Chapter 23 Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . 304
Kevin J. Downes, Gideon Stitt, and Athena F. Zuppa
Chapter 24 Multiple Organ Dysfunction Syndrome . . . . . . . . . . . . . . . . . . . .323
Bereketeab Haileselassie, L. Nelson Sanchez-Pinto, and Timothy T. Cornell
PART TWO ■ EMERGENCY CARE AND ACUTE MANAGEMENT
Section I ■ InitialStabilization . . . . . . . . . . . . . . . . . . . .341
Section Editors: Anne-Marie Guerguerian and Niranjan “Tex” Kissoon
Chapter 25 AirwayManagement..........................341
Jacqueline Soo May Ong, Janice A. Tijssen, Benjamin Berendinus Bruins, and Akira Nishisaki
Chapter 26 Cardiopulmonary Resuscitation . . . . . . . . . . . . . . . . . . . . . . 366
Amanda J. O’Halloran, Ryan W. Morgan, Todd J. Kilbaugh, Hiroshi Kurosawa, Vinay M. Nadkarni,
Antonio Rodríguez-Nüñez, Robert M. Sutton, Alexis A. Topjian, and Robert A. Berg
StabilizationandTransport . . . . . . . . . . . . . . . . . . . . . . . .386
Monica E. Kleinman, Aaron J. Donoghue, Corina Noje, and Richard A. Orr
InvasiveProcedures..........................403
Gene Y. Ong, Minako Sano, Hiroshi Kurosawa, and Arun Bansal
Chapter 27
Chapter 28

Recognition and Initial Management of Shock . . . . . . . . . . . . . . . . . 424
Suchitra Ranjit, Shivakumar Shamarao, Asma Salloo, Seth B. Gray, Deepika Gandhi, Ruchi Sinha,
Simon Nadel, and Niranjan “Tex” Kissoon
Chapter 29
Chapter 30 RapidResponseSystems.........................441
Madeline Claire Burdick, Pharsai Prasertsan, Muniya Thokchom, and Gail M. Annich
Section II ■ EnvironmentalCrises . . . . . . . . . . . . . . . . . . .451
Section Editors: Christopher M. Watson and Charles L. Schleien
Chapter 31 MultipleTrauma............................451
Arthur Cooper and John Scott Baird
Chapter 32 Drowning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .477
Daniel E. Sloniewsky and Katherine V. Biagas
Chapter 33 BurnsandSmokeInhalation . . . . . . . . . . . . . . . . . . . . . . .484
Charles M. Bergman, Joy Deanna Howell, Bruce M. Greenwald, and James J. Gallagher
Chapter 34 Injury From Chemical, Biologic, Radiologic, and Nuclear Agents . . . . . . . . . . 498
Peter Silver, F. Meridith Sonnett, Zachary A. Johnson, and George L. Foltin
Chapter 35 MassCasualtyEvents..........................509
Maria Cristina Esperanza and Christopher M. Watson
Chapter 36 Poisoning..............................525
Michael A. Nares, Asumthia S. Jeyapalan, and Richard S. Weisman
Chapter 37 Thermoregulation . . . . . . . . . . . . . . . . . . . . . . . . . . . 546
Adnan M. Bakar and Charles L. Schleien
Chapter 38 EnvenomationSyndromes. . . . . . . . . . . . . . . . . . . . . . . .563
James Tibballs and Kenneth Daniel Winkel
Section III ■ Life-Support Technologies . . . . . . . . . . . . . . . . .589
Section Editors: Heidi J. Dalton, Jacques Lacroix, and Graeme MacLaren
Chapter 39 MechanicalVentilation.........................589
Justin C. Hotz, Anoopindar K. Bhalla, Gerhard K. Wolf, and Robinder G. Khemani
Chapter 40 Inhaled Gases and Noninvasive Ventilation . . . . . . . . . . . . . . . . . .610
John J. McCloskey, Heidi J. Dalton, Jacques Lacroix, and Graeme Maclaren
Chapter 41 ExtracorporealLifeSupport . . . . . . . . . . . . . . . . . . . . . . . .626
Steven A. Conrad, Gail M. Annich, Graeme Maclaren, and Heidi J. Dalton
Chapter 42 Extracorporeal Organ Support Therapy . . . . . . . . . . . . . . . . . . . 647
Katherine Phelps, Warwick W. Butt, Peter William Skippen, Philippe A. Jouvet, and James D. Fortenberry
Blood Products and Transfusion Therapy . . . . . . . . . . . . . . . . . . . 669
Oliver Karam, Stacey Lynn Valentine, Marianne E. Nellis, Philip C. Spinella, and Jennifer Lindy Webb
Chapter 43
PART THREE ■ CRITICAL CARE ORGAN SYSTEMS
Section I ■ RespiratoryDisease . . . . . . . . . . . . . . . . . . .691
Section Editors: Ira M. Cheifetz and Bo Sun
Chapter 44 RespiratoryPhysiology.........................691
Kathryn Akong, Rakesh Bhattacharjee, Kelan G. Tantisira, and Gabriel G. Haddad
Chapter 45 The Molecular Biology of Acute Lung Injury . . . . . . . . . . . . . . . . . .722
Christine Vohwinkel, Kurt R. Stenmark, Eva S. Nozik, and Todd C. Carpenter

RespiratoryMonitoring.........................740
Meredith C.G. Broberg, Jan Hau Lee, and Ira M. Cheifetz
AcuteSevereAsthma..........................763
Claire A. Stewart and Richard J. Brilli
NeonatalRespiratoryFailure. . . . . . . . . . . . . . . . . . . . . . . 776
Narayan Prabhu Iyer, Philippe S. Friedlich, Rangasamy Ramanathan, and Istvan Seri
PneumoniaandBronchiolitis . . . . . . . . . . . . . . . . . . . . . . . 797
Werther Brunow de Carvalho, Marcelo Cunio Machado Fonseca, Cíntia Johnston, and
Paulo Sérgio Lucas Da Silva
Acute Lung Injury and the Acute Respiratory Distress Syndrome . . . . . . . . . . .824
Kathleen M. Ventre, Ira M. Cheifetz, and John J. McCloskey
ChronicRespiratoryFailure . . . . . . . . . . . . . . . . . . . . . . . .867
Thomas G. Keens, Iris Ambrosio Perez, Sheila S. Kun, and Sally L. Davidson Ward
Chapter 46
Chapter 47
Chapter 48
Chapter 49
Chapter 50
Chapter 51
Chapter 52 SleepandBreathing..........................882
Sally L. Davidson Ward, Iris Ambrosio Perez, and Thomas G. Keens
Section II ■ Neuromuscular Disease . . . . . . . . . . . . . . . . . .893
Section Editor: Robert C. Tasker
Chapter 53 Electrodiagnostic Techniques in Neuromuscular Disease . . . . . . . . . . . . . . . . . . . . . . . . . . .893
Donald H. Shaffner
Chapter 54 AcuteNeuromuscularDisease . . . . . . . . . . . . . . . . . . . . . . .903
Robert C. Tasker
Chapter 55 Chronic Neuromuscular Disease . . . . . . . . . . . . . . . . . . . . . .926
Robert C. Tasker
Section III ■ NeurologicDisease. . . . . . . . . . . . . . . . . . .936
Section Editors: Courtney Leigh Robertson and Ericka L. Fink
Developmental Neurobiology, Neurophysiology, and the Pediatric Intensive Care Unit . . .936
Brian T. Kalish and Michael J. Whalen
Molecular Biology of Brain Injury . . . . . . . . . . . . . . . . . . . . . .953
Patrick M. Kochanek, Hülya Bayir, Dennis W. Simon, Ruchira Menka Jha, Travis C. Jackson, and
Robert S. B. Clark
EvaluationoftheComatoseChild . . . . . . . . . . . . . . . . . . . . . 977
Darryl K. Miles and Nicholas S. Abend
NeurologicMonitoring.........................990
Nicole Fortier O’Brien and Kerri L. Larovere
NeurologicImaging..........................1004
David Joshua Michelson and Stephen Ashwal
Neurosurgical and Neuroradiologic Critical Care . . . . . . . . . . . . . . . 1022
Matthew Luchette, Craig McClain, and Michael L. McManus
HeadandSpinalCordTrauma . . . . . . . . . . . . . . . . . . . . . .1037
Michelle E. Schober and P. David Adelson
AbusiveHeadTrauma.........................1069
Dennis W. Simon, Nikki Miller Ferguson, Katelyn M. Even, and Rachel Pardes Berger
StatusEpilepticus...........................1078
Craig A. Press, Mark S. Wainwright, and Alexis A. Topjian
Chapter 56
Chapter 57
Chapter 58
Chapter 59
Chapter 60
Chapter 61
Chapter 62
Chapter 63
Chapter 64

Cerebrovascular Disease and Stroke . . . . . . . . . . . . . . . . . . . .1099
John Pappachan, Courtney Leigh Robertson, and Fenella J. Kirkham
Hypoxic-Ischemic Encephalopathy . . . . . . . . . . . . . . . . . . . . .1125
Ericka L. Fink, Mioara D. Manole, Jeremy R. Herrmann, and Robert S. B. Clark
Metabolic Encephalopathies in Children . . . . . . . . . . . . . . . . . . .1144
Laurence Ducharme-Crevier, Philippe A. Jouvet, and Geneviève Du Pont-Thibodeau
Chapter 65
Chapter 66
Chapter 67
Chapter 68 The Determination of Brain Death . . . . . . . . . . . . . . . . . . . . .1159
Thomas A. Nakagawa and Mudit Mathur
Section IV ■ Cardiovascular Disease . . . . . . . . . . . . . . . . . 1171
Section Editors: Paul A. Checchia and Jamie McElrath Schwartz
Chapter 69 CardiacAnatomy...........................1171
Seth B. Gray, Zdenek Slavik, Siew Yen Ho, and Steven M. Schwartz
Chapter 70 CardiovascularPhysiology . . . . . . . . . . . . . . . . . . . . . . . 1185
Peter E. Oishi, Emin Maltepe, and Jeffrey R. Fineman
Chapter 71 Cardiorespiratory Interactions in Children With Heart Disease . . . . . . . . . . .1202
Ronald A. Bronicki and Lara S. Shekerdemian
Chapter 72 HemodynamicMonitoring. . . . . . . . . . . . . . . . . . . . . . . .1214
Ronald A. Bronicki and Neil C. Spenceley
Chapter 73 Heart Failure: Etiology, Pathophysiology, and Diagnosis . . . . . . . . . . . . .1230
Candace N. Mannarino, Conrad Leon Epting, John M. Costello, Mary E. McBride, and
Karl Sherif Boshra Migally
Chapter 74 Cardiomyopathy, Myocarditis, and Mechanical Circulatory Support . . . . . . . . .1241
William G. Harmon, Ann Karimova, Timothy Thiruchelvam, and Aparna Hoskote
Chapter 75 Treatment of Heart Failure: Medical Management . . . . . . . . . . . . . . . 1267
Kathryn Restaino, Jack F. Price, David P. Nelson, and Joseph W. Rossano
Chapter 76 Treatment of Heart Failure: Mechanical Support . . . . . . . . . . . . . . . .1278
Kriti Puri and Iki Adachi
Chapter 77 ThoracicTransplantation. . . . . . . . . . . . . . . . . . . . . . . .1289
Nikoleta S. Kolovos
Chapter 78 Cardiac Conduction, Dysrhythmias, and Pacing . . . . . . . . . . . . . . . .1303
Iqbal El Assaad, Peter F. Aziz, Benjamin Hammond, Akash Patel, and Bradley S. Marino
Chapter 79 Preoperative Care of the Pediatric Cardiac Surgical Patient . . . . . . . . . . . .1331
Adam W. Lowry, Jennifer Gauntt, Mahsheed Taeb, and Jennifer J. Schuette
Chapter 80 Postoperative Care of the Pediatric Cardiac Surgical Patient . . . . . . . . . . . 1344
Ronald A. Bronicki, John M. Costello, Jason R. Buckley, and Kate L. Brown
Chapter 81 PulmonaryHypertension. . . . . . . . . . . . . . . . . . . . . . . .1368
Monique R. Radman, Jessica A. Barreto, and John K. McGuire
Section V ■ Immunologic Diseases . . . . . . . . . . . . . . . . . .1379
Section Editors: Michael C. Spaeder and Joseph A. Carcillo
Chapter 82 TheImmuneSystem..........................1379
Nazima Pathan, Michael J. Carter, and Nigel J. Klein
Chapter 83 Neurohormonal Control in the Immune System . . . . . . . . . . . . . . . . 1395
Kathryn A. Felmet and John J. McCloskey
Chapter 84 The Polymorphonuclear Leukocyte in Critical Illness . . . . . . . . . . . . . . .1407
Jennifer A. Muszynski and Jocelyn R. Grunwell

The Immune System and Viral Illness . . . . . . . . . . . . . . . . . . . .1422
Michael J. Carter, Nigel J. Klein, and Nazima Pathan
Immune Modulation and Immunotherapy in Critical Illness . . . . . . . . . . . . 1438
Katherine E. Bline and Mark W. Hall
Chapter 85
Chapter 86
Chapter 87 Immune Deficiency Disorders . . . . . . . . . . . . . . . . . . . . . . .1449
Kristen M. Lutzkanin
Infectious Diseases
Section VI ■ . . . . . . . . . . . . . . . . . . 1469
Section Editors: Mark W. Hall and Sunit C. Singhi
Chapter 88 BacterialSepsis...........................1469
Julie C. Fitzgerald, Kathleen Chiotos, and Scott L. Weiss
Chapter 89 Principles of Antimicrobial Therapy . . . . . . . . . . . . . . . . . . . . 1490
Cheryl L. Sargel, Todd J. Karsies, R. Zachary Thompson, and Su Jin Joo
Chapter 90 Dengue and Other Hemorrhagic Viral Infections . . . . . . . . . . . . . . . .1520
Siripen Kalayanarooj, Vipa Thanachartwet, and Rakesh Lodha
Chapter 91 CriticalViralInfections . . . . . . . . . . . . . . . . . . . . . . . . .1537
Rakesh Lodha, Nitin Dhochak, Sunit C. Singhi, and James D. Campbell
Chapter 92 Central Nervous System Infections . . . . . . . . . . . . . . . . . . . . .1560
Pratibha D. Singhi, Arushi Gahlot Saini, and Sunit C. Singhi
Chapter 93 Nosocomial Infections in the Pediatric Intensive Care Unit . . . . . . . . . . . . 1607
Jill Siegrist Thomas, Keith E. Hiatt, and Jason W. Custer
Chapter 94 International and Emerging Infections . . . . . . . . . . . . . . . . . . . .1629
Mark W. Hall
Chapter 95 Toxin-RelatedDiseases. . . . . . . . . . . . . . . . . . . . . . . . .1645
M. Jayashree, Sunit C. Singhi, John Paul Straumanis, and Jerin C. Sekhar
Chapter 96 OpportunisticInfections. . . . . . . . . . . . . . . . . . . . . . . . .1670
Sushil K. Kabra and Matthew B. Laurens
Nutritional and Gastrointestinal Disorders
Section VII ■ . . . . . . . . 1690
Section Editors: Jennifer G. Duncan and Nilesh M. Mehta
Chapter 97 Principles of Gastrointestinal Physiology, Nutrition, and Metabolism . . . . . . . . .1690
Stephanie G. Patterson, Z. Leah Harris, and Patrick O’Neal Maynord
Chapter 98 NutritionalSupport..........................1711
Werther Brunow de Carvalho, Artur Figueiredo Delgado, and Heitor Pons Leite
Chapter 99 Secretory and Motility Issues of the Gastrointestinal Tract . . . . . . . . . . . . .1730
Samuel Nurko
Chapter 100 GastrointestinalBleeding. . . . . . . . . . . . . . . . . . . . . . . . 1739
Wenly Ruan, Sabina Mir, and Douglas S. Fishman
Chapter 101 Abdominal Compartment Syndrome . . . . . . . . . . . . . . . . . . . .1750
Ben D. Albert and Christopher Weldon
Chapter 102 TheAcuteAbdomen..........................1757
Tomas Iölster, Ricardo D. Russo, Alejandro Siaba Serrate, and Silvio Fabio Torres
Chapter 103 Diagnostic Imaging of the Abdomen . . . . . . . . . . . . . . . . . . . .1773
Noah M. Seymore IV and Rebecca Hulett Bowling
Chapter 104 Acute Liver Failure and Liver Transplantation . . . . . . . . . . . . . . . . . 1800
Luc Morin and Pierre J. Tissieres

Chapter 105 Pediatric Intestinal and Multivisceral Transplantation . . . . . . . . . . . . . . 1823
Ajai Khanna, Geoffrey J. Bond, Rajesh K. Aneja, Kyle A. Soltys, Jeffrey A. Rudolph,
Rakesh K. Sindhi, and George V. Mazariegos
Section VIII ■ Renal, Endocrine, and Metabolic Disorders . . . . . . . . . 1838
Section Editors: Katherine V. Biagas and Charles L. Schleien
Chapter 106 AdrenalDysfunction..........................1838
Abeer Hassoun, Virginia L. Rahming, and Sharon E. Oberfield
Chapter 107 Disorders of Glucose Homeostasis . . . . . . . . . . . . . . . . . . . . .1853
Edward Vincent S. Faustino, Stephan Siebel, Michael F. Canarie, Clifford W. Bogue, and
Stuart A. Weinzimer
Chapter 108 Disorders of Water, Sodium, and Potassium Homeostasis . . . . . . . . . . . . .1868
James Schneider and Lily Glater-Welt
Chapter 109 Disorders of Calcium, Magnesium, and Phosphate . . . . . . . . . . . . . . .1892
Kenneth J. Banasiak
Chapter 110 ThyroidDisease...........................1906
Ori Eyal and Susan R. Rose
Chapter 111 AcuteKidneyInjury..........................1918
Abby Basalely, James Schneider, and Christine B. Sethna
Chapter 112 Chronic Kidney Disease, Dialysis, and Kidney Transplantation . . . . . . . . . . .1933
Katherine Mai, Katarina Supe-Markovina, and Pamela Singer
Chapter 113 HypertensiveCrisis..........................1942
George Ofori-Amanfo, Iris Mandell, and Shubhi Kaushik
Chapter 114 InbornErrorsofMetabolism . . . . . . . . . . . . . . . . . . . . . . .1954
Katie Beth Williams, Wendy K. Chung, and Michael Wilhelm
Oncologic and Hematologic Disorders
Section IX ■ . . . . . . . . . . 1968
Section Editor: Joseph D. Tobias
Chapter 115 Cancer Therapy: Mechanisms and Toxicity . . . . . . . . . . . . . . . . . .1968
David M. Loeb, Masanori Hayashi, and Moriah Rabin
Chapter 116 Oncologic Emergencies and Complications . . . . . . . . . . . . . . . . . 1980
Fernando F. Corrales-Medina, Monica Alba-Sandoval, Taumoha Ghosh, Aditi Dhir,
Alyson E. Trillo, Fiorela Hernandez-Tejada, Guillermo De Angulo, and Matteo M. Trucco
Chapter 117 HematologicEmergencies . . . . . . . . . . . . . . . . . . . . . . . .2003
Michael Conor McCrory, Saleh Bhar, and R. Blaine Easley
Chapter 118 Critical Illness Following Hematopoietic Cell Transplantation . . . . . . . . . . . 2027
Megan C. Daniel and Rajinder Pal Singh Bajwa
Chapter 119 Coagulation Issues in the Pediatric Intensive Care Unit(s) . . . . . . . . . . . . .2043
Robert I. Parker and Kristen Nelson McMillan
Chapter 120 SickleCellDisease..........................2071
Kevin J. Sullivan, L. Vandy Black, Lara Nicolas, Shirley Susana Cruz Beltran,
Jose Maria Cardenas Fimbres, Kourtney Kayanne Guthrie, and Niranjan “Tex” Kissoon