Titolo: Renal Cell Carcinoma

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Renal Cell Carcinoma

Molecular Features and Treatment Updates

Editore

Springer

Anno

2017

Pagine

381

ISBN

9784431555308

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This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.

Epidemiology of Renal Cell Carcinoma

Wu, Xifeng (et al.)

Pages 1-18
Hereditary Renal Cell Carcinoma

Baba, Masaya (et al.)

Pages 19-82
Molecular Genetics of Renal Cell Carcinoma

Fukawa, Tomoya (et al.)

Pages 83-103
Pathology of Renal Cell Carcinoma

Mikami, Shuji (et al.)

Pages 105-137
Imaging Features of Renal Cell Carcinoma Differential Diagnosis, Staging, and Posttreatment Evaluation

Jinzaki, Masahiro (et al.)

Pages 139-176

Treatment Overview

Kondo, Tsunenori

Pages 177-207
Natural History and Active Surveillance

Bhatt, Jaimin R. (et al.)

Pages 209-220
Surgical Treatment for Renal Cell Carcinoma

Kim, Dae Y. (et al.)

Pages 221-235
Predictive and Prognostic Markers in Metastatic Renal Cell Carcinoma

Ruiz Morales, José Manuel (et al.)

Pages 237-251
Tyrosine Kinase Inhibitors: Sorafenib, Sunitinib, Axitinib, and Pazopanib

Kyriakopoulos, Christos E. (et al.)

Pages 253-272
Mammalian Targets of Rapamycin Inhibitors: Temsirolimus and Everolimus

Porta, Camillo (et al.)

Pages 273-294
Immunotherapy for Renal Cell Cancer (RCC)

Kitano, Shigehisa (et al.)

Pages 295-317
Treatment for Non-clear Cell Renal Cell Carcinoma

Sumitomo, Makoto

Pages 319-332
Forthcoming Drugs for Metastatic Renal Cell Carcinoma Therapy

Ito, Keiichi

Pages 333-349
Refractory Mechanisms

Oya, Mototsugu (et al.)

Pages 351-367
Optimization of Therapy by Pharmacokinetic–Pharmacodynamic Analyses

Imamura, Chiyo K.

Pages 369-381