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Definitions
Pages 3-3
This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.
Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery.
Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.
"In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields."
- Geoffrey C. Gurtner, MD, FACS
Johnson and Johnson Distinguished Professor of Surgery
Professor (by courtesy) of Bioengineering and Materials Science
Inaugural Vice Chairman of Surgery for Innovation
Stanford University School of Medicine
Definitions
Pages 3-3
History of Regenerative Medicine
Pages 5-6
Basic Principles and Current Approach for Soft Tissue Regeneration
Pages 7-15
Sophisticated Biocomposite Scaffolds from Renewable Biomaterials for Bone Tissue Engineering
Pages 17-31
Mechanotransduction in Wound Healing and Scar Formation
Pages 35-45
Stromal Cell-Derived Factor 1 (SDF-1) Signaling and Tissue Homeostasis
Pages 47-59
Stem Cell Differentiation Directed by Material and Mechanical Cues
Pages 61-67
Bacteriophages: A New (Yet Old) Weapon Against Infections
Pages 69-79
Bacteriophages as Biocontrol Agents of Biofilm Infections Associated with Abiotic Prosthetic Devices
Pages 81-99
Extracellular Vesicles Derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential
Pages 101-111
Anti-Biofilm Activity of Viruses, Bacteria, Fungi, and Lichens: Mechanisms and Impact on Clinical Practice
Pages 113-122
Bionic Reconstruction: The New Frontier
Pages 125-128
Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators
Pages 129-149
Biomimetics: A New Abstraction for Bone Implant Design
Pages 151-157
The Role of Microbiota in Skin Regeneration
Pages 159-164
Erythropoietin: An Innovative Therapeutic Approach in Thermal Trauma
Pages 165-172
Targeting C-Reactive Protein in Inflammatory Disease
Pages 173-186
Stem Cell Therapies for Tissue Regeneration and Wound Healing: Strategies to Enhance Therapeutic Effectiveness
Pages 187-199
Iron Chelators & HIF-1α: A New Frontier for Skin Rejuvenation
Pages 201-209
How to Overcome the Valley of Death from Basic Science to Clinical Trials
Pages 213-220
Moving Your Results from Bench to Bedside: Protecting Scientific Findings
Pages 221-227
The Regulatory Landscape of Cell- and Tissue-Based Regenerative Medicine: Current Challenges and Emerging Issues
Pages 229-243
Translational Challenges in Soft Tissue Regeneration
Pages 245-281
Bone Tissue Engineering Challenges in Craniofacial Reconstructive Surgeries
Pages 283-292
Translational Challenges: Lymph Node Tissue Engineering
Pages 293-301
Implementing Tissue Engineering and Regenerative Medicine Solutions in Silicone Implants
Pages 303-318
Microdeformational Wound Therapy
Pages 321-328
Clinical Treatment of Hypertrophic Scars
Pages 329-335
Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells
Pages 337-348
Reconstruction of Post-Traumatic Maxillary Ridges Using a Radial Forearm Free Flap and Allogeneic Tissue-Engineered Bone Grafts
Pages 349-355
Postoperative Complications of Mandibular Fracture Management
Pages 357-363
Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the Head and Neck Region
Pages 365-393
Advances in Facial Nerve Paralysis: Surgical Innovation, Tissue Engineering, and Emerging Technology
Pages 395-409
Management of Capsular Contracture: Non-surgical and Surgical Options
Pages 411-428
Soft Tissue Reconstruction of the Lower Limb
Pages 429-458
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