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Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters
Pages 1-6
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters
Pages 1-6
The Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies
Pages 9-43
Mathematical Modeling of Blood Flow in the Cardiovascular System
Pages 45-70
A Biphasic Poroelasticity Model for Soft Tissue
Pages 71-88
Physical Properties of Single Cells and Collective Behavior
Pages 89-121
The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging
Pages 123-150
Mathematical Methods in Medical Image Processing
Pages 153-166
Acceleration Strategies for Data Sampling in MRI
Pages 167-186
4D Flow MRI
Pages 187-212
CEST MRI
Pages 213-253
Innovative PET and SPECT Tracers
Pages 255-279
Methods and Approaches in Ultrasound Elastography
Pages 281-302
Photoacoustic Imaging: Principles and Applications
Pages 303-324
Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction
Pages 325-339
Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology
Pages 343-372
Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms
Pages 373-381
Diffusion-Based MRI: Imaging Basics and Clinical Applications
Pages 383-393
Quantification of Functional Heterogeneities in Tumors by PET Imaging
Pages 395-410
Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound
Pages 411-427
Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease
Pages 429-449
Radionuclide Imaging of Cerebral Blood Flow
Pages 451-469
Cardiac Perfusion MRI
Pages 471-485
Myocardial Perfusion Assessment by 3D and 4D Computed Tomography
Pages 487-497
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