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Historical Perspective on the Classification and Nomenclature of Pulmonary Hypertension
Pages 3-15
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Pulmonary Hypertension
Basic Science to Clinical Medicine
Maron, Zamanian, Waxman
Editore
Springer
Anno
2016
Pagine
371
ISBN
9783319235936
140,00 €
This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles that increases pulmonary vascular resistance to affect cardiopulmonary hemodynamic and right ventricular function adversely, resulting in a clinical syndrome of diminished exercise tolerance, shortness of breath, and heart failure-associated morbidity and mortality. Owing to the availability of novel pulmonary circulation-selective pharmacotherapies over the previous decade, the number of pulmonary hypertension patients eligible for treatment has increased substantially. Despite this progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling. Taken together, a key educational opportunity is exposed to bridge this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension.
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The Defining Characteristics of Pulmonary Arterial Hypertension
Pages 17-28
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Pulmonary Hypertension in Patients Without Pulmonary Arterial Hypertension
Pages 29-61
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Epidemiology of Pulmonary Hypertension: From Quaternary Referral Centre to the Community
Pages 63-79
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The Effects of Chronic Hypoxia on Inflammation and Pulmonary Vascular Function
Pages 83-103
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Genetics of Pulmonary Vascular Disease
Pages 105-121
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Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension
Pages 123-133
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Pulmonary Hypertension as a Metabolic Disease
Pages 135-145
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Renin-Angiotensin-Aldosterone and Other Neurohumoral Factors in the Pathogenesis of Pulmonary Hypertension
Pages 147-158
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Animal Models of Pulmonary Hypertension
Pages 161-172
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The Cardiopulmonary Hemodynamic Evaluation of Pulmonary Hypertension
Pages 173-198
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Advanced Imaging in Pulmonary Hypertension
Pages 199-217
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Assessing Disease State in the Pulmonary Vasculature in Clinical Practice and Research
Pages 219-229
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Biomarkers and Other Methods for Assessing Patient Progress
Pages 231-240
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Pulmonary Circulatory – Right Ventricular Uncoupling: New Insights Into Pulmonary Hypertension Pathophysiology
Pages 241-253
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Contemporary Pharmacotherapies Involving Nitric Oxide, Prostacyclin, and Endothelin Receptor Signaling Pathways
Pages 257-270
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Determining the Optimal Approach to Initiating Oral, Inhaled, and Intravenous Therapies in Clinical Practice: Sequential Goal-Directed Therapy Is Best
Pages 271-276
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Determining the Optimal Approach to Initiating Oral, Inhaled, and Intravenous Therapies in Clinical Practice: Maximal Upfront Therapy Is Best
Pages 277-282
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Surgery, Devices, Transplantation and Other Interventional Options for the Treatment of Advanced Pulmonary Hypertension
Pages 283-306
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Patient Registries in Pulmonary Arterial Hypertension: the Role of Survival Equations and Risk Calculators
Pages 307-325
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Support Care for the Pulmonary Hypertension Patient
Pages 327-343
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Special Considerations for the Pulmonary Hypertension Patient
Pages 345-358
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The Future of Pulmonary Hypertension
Pages 359-367
