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This is a comprehensive, in-depth presentation of pulmonary aspergillosis that takes into consideration recent advances in diagnosis and management. Aspergillus is an opportunistic fungus that is ubiquitous in nature and is unique in the spectrum of illness that it may cause. These may range from fulminant invasive pulmonary aspergillosis (IPA) to chronic pulmonary infection to a hypersensitivity reaction in the form of allergic bronchopulmonary aspergillosis (ABPA).
IPA was primarily associated with severe immunocompromised diseases such as leukemia or bone marrow transplantation and diagnosis and management proved difficult. However, there have been significant advances in the diagnosis with the use of non-invasive biomarkers and in the management with more tolerable and effective antifungal agents. The COVID-19 pandemic has also played a role in making pulmonary aspergillosis much more prevalent with expanding risk factors across populations. This book aims to fill the gap and prepare clinicians to deal with this previously rare disease.
The text is divided into six sections. Expert authors start with the basics of microbiology, immunology, and pathology and then move on to clinical and diagnostic considerations. The text is then divided between IPA, chronic pulmonary aspergillosis, and ABPA and the specific considerations of each are detailed. Finally, chapters cover specific and unique areas that complement the full understanding of this topic.
The wide spectrum of conditions associated with pulmonary aspergillosis, the expanding risk factors and the improvement in the diagnosis and management of these conditions, make this entity relevant to all pulmonologists, intensivists, and infectious disease specialists rather than only those practicing in highly specialized centers.
Pages i-xviii
Front Matter
Pages 1-1
Pages 3-9
Immunology and Pathogenesis of Pulmonary Aspergillosis
Pages 11-25
Pathology of Pulmonary Aspergillosis
Pages 27-35
Front Matter
Pages 37-37
The Spectrum of Pulmonary Aspergillosis: An Overview
Pages 39-50
Role of Imaging in Pulmonary Aspergillosis
Pages 51-66
Diagnostic Studies: Role of Biomarkers
Pages 67-85
Role of Bronchoscopy and Lung Biopsy in the Diagnosis and Management of Pulmonary Aspergillosis
Pages 87-99
Antifungal Agents and Their Role in the Management of Pulmonary Aspergillosis
Pages 101-119
Surgical Management of Pulmonary Aspergillosis
Pages 121-129
Front Matter
Pages 131-131
Pages 133-142
Pulmonary Aspergillosis in Solid Organ Transplant
Pages 143-153
Virus-Associated Pulmonary Aspergillosis
Pages 155-165
Invasive Pulmonary Aspergillosis in Critically Ill Patients
Pages 167-173
Spectrum of Pulmonary Aspergillosis in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Pages 175-185
Invasive Pulmonary Aspergillosis in Other Patient Populations
Pages 187-197
Front Matter
Pages 199-199
Spectrum of Chronic Pulmonary Aspergillosis
Pages 201-211
Management of Chronic Pulmonary Aspergillosis
Pages 213-223
Front Matter
Pages 225-225
Allergic Bronchopulmonary Aspergillosis and Asthma
Pages 227-256
Allergic Bronchopulmonary Aspergillosis and Cystic Fibrosis
Pages 257-278
Allergic Fungal Rhinosinusitis
Pages 279-286
Front Matter
Pages 287-287
Pulmonary Aspergillosis: The Multidisciplinary Team Approach to Diagnosis and Management
Pages 289-297
Invasive Pulmonary Aspergillosis in the Paediatric Patient
Pages 299-306
Extrapulmonary Manifestations of Aspergillosis
Pages 307-317
Aspergillosis Overlap Syndromes
Pages 319-330
Non-Aspergillus Pulmonary Mold Infections
Pages 331-350
Pages 351-356
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