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Introduction
Pages 3-8
This book serves as the primary reference for precision medicine in the fields of pulmonary, critical care and sleep medicine by documenting principles written by experts in several aspects of precision medicine. It combines fundamental concepts of the field with state-of-the-art studies and how they translate into individual preventive, diagnostic and therapeutic plans.
Precision medicine is focused on the integration of individual variability with disease prevention and treatment principles derived from population studies. This concept has risen to prominence in recent years in parallel with advances in genetics, molecular diagnostics and novel target-specific therapies. This fundamental shift in the approach to treatment has broad implications in how we prevent, diagnose and treat disease. Describing key concepts of precision medicine and relating these to pulmonary, critical care and sleep disorders is essential to educate relevant stakeholders and increase the impact of pulmonary precision medicine.
The book is organized into seven sections: introduction; genetics; biomarkers; precise phenotyping; mobile health, wearables and telemedicine; precision therapeutics; and enabling widespread adoption of precision medicine. The chapters are organized with an introduction to the specific theme, followed by its basic concepts. They then delve into how these basic concepts relate to the larger theme of precision medicine, new precision medicine approaches to dealing with these problems, and key takeaway points. Liberally illustrated with images, figures, and tables, the text is thorough and intuitive for clinicians and researchers to learn the processes and applications of precision medicine.
This is an ideal guide for clinicians to learn new precision medicine concepts in the fields of genetics, genomics, mobile health, and how they apply to their practice and their patients, as well as researchers seeking a basic understanding of precision medicine to assist in designing future research studies.
Introduction
Pages 3-8
Differential Diagnosis of Diffuse Pulmonary Disorders Using Genetics
Pages 11-23
Genetics and Pharmacogenetics of Asthma
Pages 25-37
Genetics and Pharmacogenetics of COPD
Pages 39-55
The Evolution of Precision Medicine in Cystic Fibrosis
Pages 57-69
Genetics of Idiopathic Pulmonary Fibrosis
Pages 71-85
Genetics of Lung Cancer
Pages 87-103
Chest Imaging for Precision Medicine
Pages 107-115
Biobanking for Pulmonary, Critical Care, and Sleep Medicine
Pages 117-130
Biomarkers in Obstructive Airway Diseases
Pages 131-153
Biomarkers in Interstitial Lung Diseases
Pages 155-165
Molecular Diagnostics in Pulmonary Infections
Pages 167-184
Biomarkers in Critical Care Illness: ARDS and Sepsis
Pages 185-198
Lessons for Precision Medicine from Lung Cancer
Pages 201-223
COPD Phenotyping
Pages 225-239
Precision Medicine in Pulmonary Hypertension
Pages 241-255
Identifying Subtypes of Obstructive Sleep Apnea
Pages 257-266
Precision Medicine in Critical Illness: Sepsis and Acute Respiratory Distress Syndrome
Pages 267-288
Mobile Applications and Wearables for Chronic Respiratory Disease Monitoring
Pages 291-304
Personal Environmental Monitoring
Pages 305-320
Tele-ICU in Precision Medicine: It’s Not What You Do, But How You Do It
Pages 321-331
Lung Transplantation and Precision Medicine
Pages 335-353
Precision in Mechanical Ventilation
Pages 355-367
Precision Medicine for Cigarette Smoking Addiction
Pages 369-381
Implementing COPD Precision Medicine in Clinical Practice
Pages 383-392
Precision Medicine for All: Minority Health
Pages 395-407
Education for the Practice of Precision Medicine in PCCSM: Creating Tomorrow’s Workforce
Pages 409-416
Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine
Pages 417-428
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