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This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed.
Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic.
Pages i-xv
Front Matter
Pages 1-1
Introduction: From ‘Tissue Diagnosis’ to Biomarkers
Pages 3-8
The Advent of Biomarker Testing
Pages 9-18
The Practical Challenges for Pathology: Multiple Rapidly Evolving Methods
Pages 19-31
Front Matter
Pages 33-33
Evolution of the Total Test Approach to Tissue Based Pathological Analysis
Pages 35-42
Pre-Analytic Phase: Test Selection; Specimen Acquisition and Handling
Pages 43-49
Pre-Analytic Phase: Specimen Type and Acquisition
Pages 51-54
Pre-Analytical Phase: Biopsy/Tissue Handling and Processing
Pages 55-67
Analytical Phase: Protocol and Antigen Retrieval
Pages 69-76
Analytical Phase: Principles for Immunohistochemistry (IHC)
Pages 77-88
Analytical Phase: Current Controls; Fit for Purpose Selection and Validation
Pages 89-100
Analytical Phase: Alternative and New Control Systems
Pages 101-114
Post-Analytic Phase: Interpretation, Scoring and Reporting of Biopsy Results
Pages 115-124
Description and Interpretation of Results; The Pathology Report
Pages 125-136
Immunofluorescence, In Situ Hybridization and Alternative Forms of ‘Labeled’ Microscopy
Pages 137-152
Front Matter
Pages 153-153
Implementation of Precision Cancer Diagnostic Test
Pages 155-167
Role of Pathologist in Precision Cancer Diagnosis
Pages 169-181
Role of Pathologist in Precision Molecular and Digital Image Analyses
Pages 183-195
Front Matter
Pages 197-197
Introduction to Digital and Computational Pathology
Pages 199-203
AI in the Pre-Analytical Phase
Pages 205-210
Pages 211-215
AI in the Post-Analytical Phase
Pages 217-223
Pages 225-232
Pages 233-237
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