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Presenting an overview of the current understanding of the pathophysiology of PCOS and a paradigm for the clinical evaluation and management of the disorder, Polycystic Ovary Syndrome is written in an easy to digest, concise format that, with bulleted key points introducing each chapter, is suitable for the trainee and the busy clinician. The breadth and depth of coverage of today’s queries and controversies will be of particular interest to the specialist and researcher. An international group of leading experts addresses the varied etiologies of PCOS, comprehensively covering the contemporary treatment approaches and long-term implications of PCOS, a common yet poorly understood disorder. Chapters on treatment will be of particular relevance to the clinician and the trainee as they cover conventional therapies, lifestyle, and diet, as well as address emerging strategies such as the use of statins and surgery in PCOS management.
Spanning the breadth of clinical presentations and morbidities related to the diagnosis of PCOS, Polycystic Ovary Syndrome is an exceptional resource for primary care providers, gynecologists, reproductive endocrinologists, and others involved in the care of these patients, and provides the essential tools to aid clinicians in initiating a timely diagnostic workup and appropriate interventions to address both the immediate and long-term sequelae related to PCOS.
Contents
Part I PCOS Epidemiology and Diagnosis
1 Diagnostic Criteria and Epidemiology of PCOS .................................. 3
Heather R. Burks and Robert A. Wild
2 Polycystic Ovarian Syndrome: A Diagnosis of Exclusion ................... 11
Jennifer Wolf, Courtney L. Barnes, and Mira Aubuchon
Part II Pathophysiology of PCOS
3 Recent Advances in the Genetics of Polycystic
Ovary Syndrome ..................................................................................... 29
Michelle R. Jones, Ning Xu, and Mark O. Goodarzi
4 Ovarian Dysfunction in Polycystic Ovary Syndrome .......................... 53
Helen D. Mason, Nafi Dilaver, and Suman Rice
5 The Role of the Adrenal Glands in the Hyperandrogenism
Associated with Polycystic Ovarian Syndrome .................................... 71
Ruth Freeman
6 The Hypothalamic–Pituitary Axis in PCOS ......................................... 81
Sabrina Gill and Janet E. Hall
7 Insulin Resistance and Lipotoxicity in PCOS:
Causes and Consequences ...................................................................... 95
Sylvain Bellanger, Marie-Claude Battista,
and Jean-Patrice Baillargeon
8 Obesity, Metabolic Dysfunction, and Infl ammation
in Polycystic Ovary Syndrome ............................................................... 117
Mira Aubuchon, Jennifer A. Bickhaus, and Frank González
Part III Managing PCOS
9 Role of Lifestyle and Diet in the Management
of Polycystic Ovarian Syndrome............................................................ 147
Amy Krystock
10 Role of Insulin-Sensitizing Drugs in PCOS Management ................... 165
Johnny T. Awwad and Ghina Ghazeeri
11 Role of Statins in PCOS Management .................................................. 181
Israel Ortega and Antoni J. Duleba
12 Managing PCOS-Related Infertility: Ovulation Induction,
In Vitro Fertilization, and In Vitro Maturation ................................... 205
Saioa Torrealday and Pasquale Patrizio
13 Managing the PCOS-Related Symptoms of Hirsutism,
Acne, and Hair Loss ................................................................................ 223
Beth McAvey and Harry Lieman
Part IV Unique Considerations in PCOS
14 PCOS in Adolescence: Diagnostic Dilemmas
and Management Considerations .......................................................... 245
Tania S. Burgert
15 Considerations and Challenges for Pregnancy
in Polycystic Ovary Syndrome ............................................................... 265
Christina Shih-chi Han and Erika F. Werner
Part V Role of Surgery in PCOS Management
16 Role of Surgery in the Management of PCOS: Rationale
and Considerations for Bariatric Surgery ............................................ 277
Héctor F. Escobar-Morreale
17 Surgical Management of Polycystic Ovary Syndrome:
A Contemporary Viewpoint on Place of Ovarian Surgery
in PCOS Management ............................................................................ 289
Phoebe H. Leonard, Jani R. Jensen, and Gaurang S. Daftary
Part VI Recognized Risks and Emerging Concepts
18 Long-Term Morbidity: Cardiovascular Disease,
Cancer, and Depression in PCOS .......................................................... 303
Lauren W. Milman and Anuja Dokras
19 Emerging Concepts: Role of Vitamin D Defi ciency
in the Pathogenesis of PCOS .................................................................. 317
Sanam Lathief and Lubna Pal
Index ................................................................................................................ 333
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