Titolo: Plasma Cell Dyscrasias

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Plasma Cell Dyscrasias

Editore

Springer

Anno

2017

Pagine

361

ISBN

9783319403182

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This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.

MGUS and Smoldering Multiple Myeloma: Diagnosis and Epidemiology

Mateos, María-Victoria (et al.)

Pages 3-12
Vision Statement for Multiple Myeloma: Future Directions

Anderson, Kenneth C.

Pages 15-22
Genomic Aberrations in Multiple Myeloma

Manier, Salomon (et al.)

Pages 23-34
Epigenetics in Multiple Myeloma

Glavey, Siobhan V. (et al.)

Pages 35-49
Role of Endothelial Cells and Fibroblasts in Multiple Myeloma Angiogenic Switch

Ribatti, Domenico (et al.)

Pages 51-61

Targeting the Bone Marrow Microenvironment

Moschetta, Michele (et al.)

Pages 63-102
Multiple Myeloma Minimal Residual Disease

Paiva, Bruno (et al.)

Pages 103-122
Treatment of Newly Diagnosed Elderly Multiple Myeloma

Fouquet, Guillemette (et al.)

Pages 123-143
Management of Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma

Laubach, Jacob (et al.)

Pages 145-167
Treatment of Relapsed/Refractory Multiple Myeloma

Neri, Paola (et al.)

Pages 169-194
Treatment of MM: Upcoming Novel Therapies

Lonial, Sagar

Pages 195-205
Role of the Immune Response in Disease Progression and Therapy in Multiple Myeloma

Lee, Susan J. (et al.)

Pages 207-225
Transplantation for Multiple Myeloma

Jethava, Yogesh S. (et al.)

Pages 227-250
Bone Disease in Multiple Myeloma

Eda, Homare (et al.)

Pages 251-270
Immunoglobulin Light Chain Systemic Amyloidosis

Dispenzieri, Angela (et al.)

Pages 273-318
Waldenstrom Macroglobulinemia: Genomic Aberrations and Treatment

Kapoor, Prashant (et al.)

Pages 321-361