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The pituitary gland is often referred to as the master gland, coordinating hormonal signals from the hypothalamus and peripheral circulation to maintain homeostasis in the body. Patients with pituitary dysfunction are faced with challenges unique to each stage of their life cycle. For example, the goals of management for a hypopituitary adolescent transitioning to adulthood would be to optimize growth and sexual development. In early adulthood, approaches that optimize of fertility in men and women can be a priority, and the management approach will be very different from that of older adults requiring sex hormone replacement.
This case-based guide will provide practical clinical guidance on approaches to the management of pituitary disorders organized by time of life, from childhood and fertile years through to older age. Sensibly divided into sections, various pituitary disorders and conditions are described and relevant treatment strategies are outlined. Sections included discussions of the unique considerations for the pituitary gland in childhood and adolescents, patients desiring fertility and pregnant patients, health optimization and non-tumoral diagnoses in adults, and management of disorders of the hypothalamic-pituitary axis in the elderly. Each chapter presents a clinical case vignette as an introduction to the concepts and a framework for the discussion of the diagnosis, management and unique consideration of each pituitary pathology.
Practical and user-friendly, Pituitary Disorders throughout the Life Cycle is an excellent resource for practicing clinical endocrinologists (pediatric, transitional care, adult) and reproductive endocrinologists as well as specialty residents and trainees.
Pages i-xvii
Front Matter
Pages 1-1
Pituitary Disorders Affecting Linear Growth: Short Stature
Pages 3-15
Pituitary Disorders Affecting Linear Growth: Tall Stature
Pages 17-31
Childhood Neoplasms and Impact on Hormones
Pages 33-49
Pages 51-59
Transitions in Care of the Adolescent with Pituitary Dysfunction
Pages 61-74
Front Matter
Pages 75-75
Maintenance of Fertility in the Male Patient with Hypogonadism
Pages 77-86
Preconception Management of Female Patients with Hypopituitarism
Pages 87-98
Acromegaly: Preconception Management
Pages 99-109
Hyperprolactinemia and Preconception Management
Pages 111-123
Cushing’s Disease: Preconception Management
Pages 125-134
Functional Gonadotroph Pituitary Adenomas: Clinical Presentation and Management
Pages 135-148
Optimization of Care for Women with Complex Pituitary Tumors Who Seek Fertility
Pages 149-161
Front Matter
Pages 163-163
Ovulation, Pregnancy, and Delivery in the Female Patient with Hypopituitarism
Pages 165-176
Management of the Patient with Acromegaly During Pregnancy
Pages 177-185
Management of the Patient with Prolactinoma During Pregnancy
Pages 187-194
Management of the Patient with Cushing’s Syndrome During Pregnancy
Pages 195-206
Pregnancy-Associated Pituitary Disorders: Hypophysitis
Pages 207-216
Pages 217-228
Front Matter
Pages 229-229
Pages 231-243
Minimising Cardiometabolic Risk Factors in Patients with Hypopituitarism
Pages 245-260
Minimizing Cardiometabolic Risk Factors in Patients with Acromegaly
Pages 261-273
Pages 275-286
Pages 287-294
Front Matter
Pages 295-295
Impact of Repetitive and Traumatic Brain Injury on Pituitary Function
Pages 297-308
Anti-neoplastic Immunomodulatory Treatments and the Pituitary
Pages 309-320
Infiltrative and Inflammatory Disorders of the Hypothalamus and Pituitary
Pages 321-340
Opioid Interference with Hypothalamic-Pituitary Function
Pages 341-350
Impact of HIV on the Hypothalamic-Pituitary Hormonal Axis
Pages 351-361
Front Matter
Pages 363-363
Surgical Risk and Outcomes for Pituitary Masses in the Elderly
Pages 365-372
Benefits and Risks of Testosterone Replacement in the Older Man with Hypogonadism
Pages 373-383
Risks and Benefits of Growth Hormone Replacement in the Elderly
Pages 385-394
Pages 395-403
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