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Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Pediatric Inflammatory Bowel Disease
Mamula, Markowitz, Baldassano
Editore
Springer
Anno
2013
Pagine
591
ISBN
9781461450610
170,00 €
- Thoroughly revised and updated second edition
- Written by specialists unsurpassed in reputation and accomplishments
- Includes new therapies that are currently being used or tested
Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use.
Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists.
xi
Contents
Part I Etiology and Pathogenesis
1 Genetics of Inflammatory Bowel Diseases .......................................................... 3
Zhi Wei, Steven Baldassano, and Hakon Hakonarson
2 Gut Immunity and Inflammatory Bowel Disease .............................................. 13
William A. Faubion
3 Cytokines and Inflammatory Bowel Disease ...................................................... 25
Edwin F. de Zoeten and Ivan J. Fuss
4 The Gut Microbiota and IBD ............................................................................... 35
Judith Kelsen and Gary D. Wu
Part II Epidemiology and Clinical Features
5 Epidemiology of Pediatric Inflammatory Bowel Disease .................................. 45
Shehzad Saeed and Subra Kugathasan
6 Early Onset Inflammatory Bowel Disease .......................................................... 59
Melvin B. Heyman and Neera Gupta
7 The Natural History of Crohn Disease in Children ........................................... 65
James F. Markowitz
8 Natural History of Ulcerative Colitis in Children .............................................. 73
Jeffrey S. Hyams
9 Natural History of Indeterminate Colitis ........................................................... 79
Mary K. Rogers Boruta, Richard J. Grand, and Michael D. Kappelman
10 Extraintestinal Manifestations of Pediatric
Inflammatory Bowel Disease ................................................................................ 87
Shervin Rabizadeh and Maria Oliva-Hemker
11 Liver Disease in Pediatric Inflammatory Bowel Disease ................................... 95
Pamela L. Valentino and Binita M. Kamath
12 Growth Impairment in Pediatric Inflammatory Bowel Disease ....................... 109
Thomas D. Walters and Anne M. Griffiths
13 Inflammatory Bowel Diseases and Skeletal Health ............................................ 127
Francisco A. Sylvester
14 Puberty and Pediatric-Onset Inflammatory Bowel Disease .............................. 137
Dianne Deplewski and Barbara S. Kirschner
15 Classification of Inflammatory Bowel Disease in Children ............................... 147
Athos Bousvaros
xii Contents
Part III Diagnosis
16 The History and Physical Exam .......................................................................... 161
Alka Goyal and David J. Keljo
17 Differential Diagnosis of Inflammatory Bowel Disease ..................................... 165
Thierry Lamireau
18 Laboratory Evaluation of Inflammatory Bowel Disease ................................... 175
Jennifer Strople and Benjamin D. Gold
19 Radiologic Evaluation of Pediatric Inflammatory Bowel Disease .................... 189
Stephen M. Druhan and Benedict C. Nwomeh
20 Endoscopic Modalities in Pediatric Inflammatory Bowel Disease ................... 203
Krishnappa Venkatesh and Mike Thomson
21 The Pathology of Chronic Inflammatory Bowel Disease ................................... 223
Pierre Russo
22 Videocapsule Endoscopy in Inflammatory Bowel Disease ................................ 241
Ernest G. Seidman
23 Bone Health in Pediatric Inflammatory Bowel Disease ..................................... 249
Meena Thayu and Edisio Semeao
24 Assessment of Growth and Nutritional Status in Children
with Inflammatory Bowel Disease ....................................................................... 263
Babette S. Zemel
Part IV Medical Therapy
25 Pharmacogenetics in IBD ..................................................................................... 275
Marla C. Dubinsky
26 5-Aminosalicylate Therapy .................................................................................. 281
Michael Stephens and Alisha M. Mavis
27 Antibiotic Therapy ................................................................................................ 289
Howard Kader, Douglas Jacobstein, and Adam Paul
28 Nutritional Management of Inflammatory Bowel Disease ................................ 295
Anthony Otley, Andrew S. Day, and Mary Zachos
29 Probiotic Therapy ................................................................................................. 313
David R. Mack
30 Corticosteroids ...................................................................................................... 325
Johanna C. Escher
31 6-Mercaptopurine Therapy .................................................................................. 331
Carmen Cuffari
32 Methotrexate.......................................................................................................... 339
Joel R. Rosh
33 Infliximab Therapy for Pediatric Crohn Disease
and Ulcerative Colitis ........................................................................................... 345
Ilse Hoffman, Tania Claeys, Séverine Vermeire, Gert Van Assche,
Peter Witters, and Paul Rutgeerts
Contents xiii
34 Biologic Therapies ................................................................................................. 357
Wojciech Blonski, Faten Aberra, and Gary R. Lichtenstein
35 Medical Treatment of Perianal Crohn Disease Fistulae .................................... 385
Mark T. Osterman and Gary R. Lichtenstein
36 Management of Fulminant Colitis ....................................................................... 399
Harland Winter
Part V Surgical Therapy
37 Surgical Management of Crohn Disease in Children ........................................ 405
Daniel von Allmen
38 Surgical Treatment of Ulcerative Colitis ............................................................. 417
Peter Mattei
39 Pouchitis After Ileal Pouch-Anal Anastomosis ................................................... 431
Victor Uko and Robert Wyllie
40 Enteral Feeding Devices and Ostomies ............................................................... 441
Susan N. Peck
Part VI Research
41 Clinical Indices for Pediatric Inflammatory Bowel Disease Research ............. 449
Angela Noble and Dan Turner
42 Clinical Trials (Clinician Perspective) ................................................................. 467
Salvatore Cucchiara, Giovanni Di Nardo, and Marina Aloi
43 Clinical Trials (Industry Perspective) ................................................................. 473
Allan David Olson
Part VII Special Considerations
44 Psychological Aspects of IBD in Children and Adolescents .............................. 483
Laura M. Mackner and Wallace V. Crandall
45 Measurement of Quality of Life in Pediatric
Inflammatory Bowel Disease ................................................................................ 491
Anthony Otley
46 Irritable Bowel Syndrome and Functional Gastrointestinal
Disorders in Pediatric Inflammatory Bowel Disease ......................................... 505
Khalil I. El-Chammas and Manu R. Sood
47 Inflammatory Bowel Disease in Pregnancy ........................................................ 515
Sunanda Kane
48 Immunizations in the Child with Inflammatory Bowel Disease ....................... 527
Athos Bousvaros and Ying Lu
49 Malignant Tumors Arising in Inflammatory Bowel Disease ............................. 531
Thomas A. Ullman
50 Quality Improvement in Inflammatory Bowel Disease ..................................... 547
Richard B. Colletti, Michael D. Kappelman, Wallace V. Crandall,
and Peter A. Margolis
xiv Contents
51 Advocacy for Pediatric Patients with Inflammatory Bowel Disease ................ 555
Janis Arnold, Athos Bousvaros, and Jennifer C. Jaff
52 Legislative Advocacy ............................................................................................. 565
Suzanne Rosenthal and Crohn’s & Colitis Foundation of America
53 Transition from Pediatric to Adult Care ............................................................. 571
Bincy P. Abraham and George D. Ferry
Index ............................................................................................................................... 579
