Table Of Contents:

Chapter 1: Ischemia-Reperfusion Injury

Overview of Ischemia/Reperfusion (I/R)

Events in Ischemia Reperfusion Injury

Ischemic versus reperfusion components of total tissue injury induced by I/R

Bimodal tissue Responses to I/R

I/R-induced stunning and hibernation versus irreversible cell damage and death

Organ-specific susceptibility to I/R

Remote organ injury

Therapeutic Advancement during last decade

Chapter 2: Myocardial Ischemia Circulatory Arrest

Ischemic heart diseases

Consequences of Myocardial Ischemia

Ischemia-related metabolic Alterations

Treatment option of myocardial ischemia

Pre and Post conditioning

Chapter 3 Myocardial Reperfusion

Physiology of myocardial perfusion

Extra Corporeal Circulation

Role of coronary circulation

Myocardial Stunning and hibernation

Ischemia Reperfusion Injury

Oxygen free Radicals

Inflammation and activation of complement system

Increased permeability of mPTP.

Role of mitochondrial DNA

Myocardial Cellular Death

Chapter 4: Cardioprotection

Myocardial Protection related to Ischemia-Reperfusion Injury

Oxidative Stress

Apoptosis

Post-Ischemic Mechanical Assistance (Post CA)

Pharmacological targets for known ischemia-reperfusion injury mechanisms

Chapter 5: Role of Fingolimod in Cardioprotection

Sphingosine-1-phosphate

Fingolimod

History of Fingolimod

Use of Fingolimod in clinical setting

Effects of Fingolimod

The basic mechanisms of the cardiovascular effects of Fingolimod

Recommendations for safe use of fingolimod

Mechanisms of Cardioprotection by Fingolimod

Activation of RISK and SAFE Pathways

Antioxidant action

Anti-apoptotic action

Attenuation of ischemic cardiomyopathy

Role of Sphingosine 1 phosphate -HDL in Cardioprotection