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Heart Failure, Introduction
Pages 3-20
The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.
Heart Failure, Introduction
Pages 3-20
Cardiac Prevention Guidelines
Pages 21-36
Pathophysiology of Heart Failure
Pages 37-55
Calcium Signaling in Cardiovascular Physiology and Pathology
Pages 57-81
Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging
Pages 83-105
The Parasympathetic Nervous System and Heart Failure: Pathophysiology and Potential Therapeutic Modalities for Heart Failure
Pages 107-128
Risk for Sudden Cardiac Death in Heart Failure: Underlying Mechanisms and Therapeutic Modalities
Pages 129-149
Pharmacological Management of Heart Failure and Device Therapy in Heart Failure
Pages 151-164
Exercise in Heart Failure: Effectiveness Versus Safety
Pages 165-177
Cardiac Muscle and the Troponins
Pages 179-192
Circulating Cardiac Troponins as Specific Biomarkers of Myocardial Damage: Clinical Considerations
Pages 193-209
Natriuretic Peptides and Biomarkers in the Diagnosis of Heart Failure
Pages 211-229
MicroRNAs in Cardiovascular Disease: From Pathogenesis to Treatment
Pages 231-252
MicroRNA Therapeutics in Cardiovascular Disease
Pages 253-263
Gene Therapy in Cardiovascular Disease
Pages 265-287
Cardiac Hypertrophy and Hypertrophic Cardiomyopathy: Introduction and Management
Pages 291-324
Myocardial Metabolic Abnormalities and Cardiac Dysfunction
Pages 325-341
Molecular Targets in the Treatment of Cardiac Hypertrophy
Pages 343-371
Acute Coronary Syndromes: Introduction and Pathophysiologic Classification
Pages 375-395
Pathophysiology and Management of Myocardial Infarction
Pages 397-424
Pathophysiology and Lifetime Risk Factors for Atherosclerosis and Coronary Artery Disease in Women and in the Elderly
Pages 425-441
Medical Management of Chronic Stable Angina
Pages 443-466
Therapy for Acute Coronary Syndrome and Unstable Angina
Pages 467-493
Drug-Eluting Stents and Coronary Artery Disease
Pages 495-524
Atherosclerosis, Introduction and Pathophysiology
Pages 527-546
Vascular Endothelial Dysfunction and Atherosclerosis: Role of Nitric Oxide System
Pages 547-561
Cardioprotective Role of Omega-3 Polyunsaturated Fatty Acids Through the Regulation of Lipid Metabolism
Pages 563-588
Prevention and Treatment of Atherosclerotic Vascular Disease: Hypolipidemic Agents
Pages 589-611
Prevention of Cardiovascular Disease: The Polypill Concept
Pages 613-632
Hypertension: Introduction, Types, Causes, and Complications
Pages 635-653
Pathophysiology of Hypertension
Pages 655-683
Blood Pressure Genomics
Pages 685-694
Hypertension and Vascular Endothelial Growth Factors
Pages 695-707
Role of Gi Proteins in Hypertension
Pages 709-721
Sympathetic and Renin–Angiotensin Activity in the Pathophysiology of Hypertension
Pages 723-749
Drugs Targeting RAAS in the Treatment of Hypertension and Other Cardiovascular Diseases
Pages 751-806
Calcium Channel Blockers in the Treatment of Hypertension
Pages 807-822
Diuretics for the Treatment of Hypertension
Pages 823-851
Centrally Acting Antihypertensive Agents in the Treatment of Hypertension
Pages 853-868
Vasodilators and Management of Hypertensive Emergencies
Pages 869-886
Combination Therapy for the Clinical Management of Hypertension
Pages 887-902
Resistant Hypertension: Definition, Prevalence, and Therapeutic Approaches
Pages 903-917
Drug Adherence in Hypertension
Pages 919-933
The Glycemic Consequences of Antihypertensive Medications
Pages 935-948
Pathophysiology and Treatment of Pulmonary Arterial Hypertension
Pages 949-974
Cardiac Arrhythmias: Introduction, Electrophysiology of the Heart, Action Potential and Membrane Currents
Pages 977-1002
Pathophysiology of Cardiac Arrhythmias: Arrhythmogenesis and Types of Arrhythmias
Pages 1003-1014
Proarrhythmic Effects of Antiarrhythmic and Non-antiarrhythmic Drugs
Pages 1015-1038
Drug-Induced Prolongation of the QT Interval: Present and Future Challenges for Drug Discovery
Pages 1039-1057
Treatment of Atrial Fibrillation and Atrial Flutter
Pages 1059-1079
Use of Mechanical Devices to Reduce Stroke in Atrial Fibrillation
Pages 1081-1099
Antiarrhythmic Drugs and Management of Ventricular Arrhythmias
Pages 1101-1133
Cardiac Arrest and Cardiopulmonary Resuscitation: Recent Advances in Management Approach for Cardiopulmonary Resuscitation
Pages 1135-1147
Valvular Heart Disease: Introduction, Clinical Pathogenesis, and Management
Pages 1151-1185
Mitral Regurgitation in Heart Failure: Mechanisms and Therapeutic Options
Pages 1187-1199
Pathophysiology and Management of Functional Tricuspid Regurgitation
Pages 1201-1220
Aortic Valve Stenosis and Aortic Regurgitation: Pathophysiology and Treatment
Pages 1221-1246
Induction of Valvular Heart Disease by Pharmacological Interventions
Pages 1247-1265
Pathophysiology and Pharmacotherapy of Adult Congenital Heart Disease
Pages 1269-1291
Cardiac Disease in Pregnancy
Pages 1293-1313
Placental Insufficiency: The Impact on Cardiovascular Health in the Mother and Her Offspring Across the Lifespan
Pages 1315-1329
miRNAs in Cardiovascular Development
Pages 1331-1342
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