Overviews. Historical (then). Global (now). Fundamentals. The clinical approach. Taking an occupational history. Application of lung function testing to occupation lung disease. Pathology. Imaging. Non-invasive investigations (induced sputum, exhaled breath condensate and related modalities), BAL and other biomarkers. The consequences of chronic respiratory disease on employment and employability. The epidemiological approach. Measuring frequency and trends. Epidemiological methods. Investigating an outbreak. Attribution and compensation. Principles of prevention and control. The predictive approach. Predicting toxicity. Genetics and gene-environment interactions. Screening and surveillance. Interstitial and malignant diseases. Asbestos, non-asbestos silicates, MMWF. Silica. Coal. Other inorganic dusts (iron, tin, etc.). Respiratory cancers. Mesothelioma. Hypersensitivity pneumonitis. Beryllium and related granulomatous responses. Unusual or otherwise "idiopathic" interstitial lung disease (including COP). Airways diseases. Work-related asthma: occupational asthma and work-exacerbated disease. Work-related upper airway diseases. Acute inhalation injuries (chlorine et al). (sub-) acute inhalation syndromes (MMF, humidifier fever etc.). Cotton dust. COPD (including chronic bronchitis). Obliterative bronchiolitis. Welding fume and other irritant gases. Other respiratory issues. Pulmonary infections including zoonoses. Diving. Work at high altitudes. Abnormal sleep conditions and work.