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Genetics of Osteosarcoma
Pages 3-17
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Osteosarcoma
Ueda, Kawai
Editore
Springer
Anno
2016
Pagine
270
ISBN
9784431556954
120,00 €
This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.
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Basic Research for Osteosarcoma Lung Metastasis (LM8)
Pages 19-29
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Immunotherapy for Osteosarcoma
Pages 31-41
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Outcome of Treatment for Osteosarcoma of the Extremities Over the Last 20 Years: Report from 11 Referral Centers in Japan
Pages 45-57
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Osteosarcoma in the Elderly: Clinical Features and Outcome
Pages 59-71
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Prognostic Factors for Osteosarcoma Patients
Pages 73-79
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Neoadjuvant Chemotherapy Developed in Japan
Pages 83-96
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Neoadjuvant Chemotherapy: Osaka University Osteosarcoma (OOS) Regimen
Pages 97-106
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Endoprosthetic Reconstruction for Extremity Osteosarcoma
Pages 109-124
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Limb-Salvage Surgery and Reconstruction for Skeletally Immature Childhood Osteosarcoma: Extendible Endoprosthesis
Pages 125-133
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Limb Salvage Surgery for Pelvic Osteosarcoma
Pages 135-147
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Management of Postoperative Infection After Limb Salvage Surgery in Osteosarcoma Patients
Pages 149-167
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Biological Reconstruction for Extremity Osteosarcoma: Long-Term Results and Current Concept of Intraoperative Extracorporeal Irradiated Bone Graft (IORBG)
Pages 171-182
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Biological Reconstruction for Extremity Osteosarcoma: Pasteurized Autogenous Bone Graft
Pages 183-200
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Biological Reconstruction for Extremity Osteosarcoma: Liquid Nitrogen-Treated Tumor-Bearing Bone Graft
Pages 201-207
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Biological Reconstruction for Extremity Osteosarcoma: Distraction Osteogenesis Technique
Pages 209-218
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Limb-Saving Surgery Using In Situ Preparation (ISP) Method
Pages 219-227
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Carbon Ion Radiotherapy for Unresectable Osteosarcoma of the Trunk
Pages 231-243
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Treatment of Osteosarcoma Patients with Pulmonary Metastasis
Pages 245-253
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Long-Term Outcomes and Quality of Life (QOL) in Survivors of Pediatric and Adolescent Osteosarcoma
Pages 257-270
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