Chapter 7
Pseudotumors and Tumorlike
Lesions of Bone . . . . . . . . . ..........79
Lisa A. Kafchinski, MD, FAAOS, FAOA
Chapter 8
Systemic Treatment of Bone
Sarcoma . . . . . . . . . . . . .............89
Mia Weiss, MD
Sasha Haarberg, PharmD, BCOP
Angela Hirbe, MD, PhD
Chapter 9
Systemic Treatments for
Soft-Tissue Sarcoma . . . . . . . .......101
Victoria Wytiaz, MD
Rashmi Chugh, MD
Chapter 10
Radiation Therapy . . . . . . . . ........ 111
Safia K. Ahmed, MD
Section 1: General
Evaluation and Treatment of
Musculoskeletal Tumors
SECTION EDITORS:
Michelle Ghert, MD, FAAOS, FRCSC
Nicholas S. Tedesco, DO, FAAOS
Chapter 1
Evaluation of Bone Tumors . . . . . .....3
Joseph K. Kendal, MD, MSc, FRCSC
Chapter 2
Evaluation of Soft-Tissue Tumors . . .. 15
Andrew C. Cordle, MD, PhD
Carol L. Andrews, MD
Chapter 3
Biopsy . . . . . . . . . . . . . ..............25
Stella J. Lee, MD
Kurt R. Weiss, MD, FAAOS
Richard L. McGough III, MD, FAAOS
Chapter 4
Molecular Biology in the Pathogenesis
of Musculoskeletal Neoplasia . . . ....33
Michael J. Monument, MD, MSc, FRCSC, FAAOS
Kevin B. Jones, MD, FAAOS
Chapter 5
Molecular Biology in the Clinical
Management of Musculoskeletal
Neoplasia . . . . . . . . . . . . ............47
Michael J. Monument, MD, MSc, FRCSC, FAAOS
Kevin B. Jones, MD, FAAOS
Chapter 6
Tumorlike Lesions of Soft Tissue . . ...63
Nicholas S. Tedesco, DO, FAAOS
Section 2: Benign Bone
Tumors
SECTION EDITOR:
Benjamin J. Miller, MD, MS, FAAOS
Chapter 11
Benign Radiolucent Lesions . . . . ....127
John A. Abraham, MD, FAAOS, FACS
Chapter 12
Benign Cartilage Lesions . . . . . .....141
Krista A. Goulding, MD, MPH, FRCSC
Tom Joris Crijns, MD, PhD
Chapter 13
Benign Bone-Forming Tumors . . . ...155
Robert M. Henshaw, MD, FAAOS
Emily E. Carmody, MD, FAAOS

Chapter 14
Benign Fibrous Lesions and
Langerhans Cell Histiocytosis . . . ...169
Lauren Zeitlinger, DO
William M. Parrish, MD, FAAOS
Chapter 15
Giant Cell Tumor of Bone . . . . . .....179
David D. Greenberg, MD, FAAOS, FAOA
Chapter 22
Lymphoma . . . . . . . . . . . ...........265
Wakenda K. Tyler, MD, MPH, FAAOS
Soheil Sabzevari, MD
Section 4: Soft-Tissue
Tumors
SECTION EDITOR:
Patrick P. Lin, MD, FAAOS
Section 3: Malignant Primary
Bone Tumors
Chapter 23
Benign Vascular Soft-Tissue
Tumors . . . . . . . . . . . . ............. 277
Yee-Cheen Doung, MD, FAAOS
Chapter 24
Benign Cystic Soft-Tissue Lesions . .. 287
Jeffrey E. Krygier, MD, FAAOS
Chapter 25
Lipoma and Other Benign
Lipomatous Tumors . . . . . . ........ 303
Sean V. McGarry, MD, FAAOS
Chapter 26
Benign Neural Tumors . . . . . . ......311
Shahram Bozorgnia, MD
Chapter 27
Benign Fibrous Tumors . . . . . ....... 325
Robert L. Satcher Jr, MD, PhD, FAAOS
Chapter 28
Tenosynovial Giant Cell Tumor
and Synovial Chondromatosis . . .... 333
Thomas J. Utset-Ward, MD, MBA
Thomas Scharschmidt, MD, FAAOS
Chapter 29
Miscellaneous Benign Soft-Tissue
Tumors . . . . . . . . . . . . .............341
Spencer James Frink Sr, MD
SECTION EDITOR:
Carol D. Morris, MD, MS, FAAOS
Chapter 16
Conventional Osteoblastic
Osteosarcoma . . . . . . . . . ..........195
Odion Binitie, MD, FAAOS
Carol D. Morris, MD, MS, FAAOS
Chapter 17
Osteosarcoma Variants . . . . . ......207
Lisa B. Ercolano, MD, FAAOS
Chapter 18
Ewing Sarcoma and Other Undifferentiated
Small Round Cell Sarcomas . . . ..... 217
Paul Gagnet, MD
J. Sybil Biermann, MD, FAAOS
Chapter 19
Chondrosarcoma of Bone . . . . ..... 227
Richard L. McGough III, MD, FAAOS
Chapter 20
Miscellaneous Malignant Primary
Bone Tumors . . . . . . . . . . ..........241
Rosanna Wustrack, MD, FAAOS
Melissa Zimel, MD, FAAOS
Chapter 21
Multiple Myeloma . . . . . . . . ........251
Adam S. Levin, MD, FAAOS
Samir Sabharwal, MD, MPH

Chapter 30
Soft-Tissue Sarcomas . . . . . . ....... 353
Robert J. Esther, MD, MSc, FAAOS
Chapter 31
Treatment of Soft-Tissue
Sarcomas . . . . . . . . . . . ............ 367
Steven W. Thorpe, MD, FACS, FAOA
Justin E. Bird, MD, FAAOS
Section 6: Treatment of Bone
Tumors
SECTION EDITOR:
Ginger E. Holt, MD, FAAOS
Chapter 37
General Principles of Intralesional
Treatment of Bone Tumors . . . ..... 439
James P. Norris IV, MD, FAAOS
Chapter 38
General Principles of Wide
Resection of Bone Tumors . . . . ..... 453
Joshua M. Lawrenz, MD, FAAOS
Nathan W. Mesko, MD, FAAOS, FAOA
Chapter 39
Pelvic Sarcoma Resection and
Reconstruction . . . . . . . . . .......... 469
Gavin L. Mills, MD
Samuel E. Broida, MD
Matthew T. Houdek, MD, FAAOS
Chapter 40
Proximal Femur Resection and
Reconstruction . . . . . . . . . .......... 481
Christian M. Ogilvie, MD, FAAOS
Chapter 41
Distal Femoral Resection and
Reconstruction . . . . . . . . . .......... 487
Iqbal Singh Multani, MD
Mohamed Sarraj, MD
Theresa J. C. Pazionis, MD, MA, FRCSC, ABOS
Michelle Ghert, MD, FAAOS, FRCSC
Chapter 42
Proximal Tibial Resection and
Reconstruction . . . . . . . . . ..........497
Robert K. Heck Jr, MD, FAAOS
Patrick C. Toy, MD, FAAOS
Chapter 43
Upper Extremity Resection and
Reconstruction . . . . . . . . . .......... 507
Kelly C. Homlar, MD, FAAOS
Jennifer L. Halpern, MD, FAAOS
Section 5: Metabolic Disease
to Bone
SECTION EDITOR:
Wakenda K. Tyler, MD, MPH, FAAOS
Chapter 32
The Pathophysiology of
Bone Metastasis . . . . . . . . ......... 381
Valerie A. Fitzhugh, MD
Chapter 33
Approach to the Patient With
Bone Metastasis . . . . . . . . .........393
Frank Chiarappa, MD
Tessa Balach, MD, FAAOS
Chapter 34
Surgical Management of Upper
Extremity Bone Metastases: A
Treatment Algorithm . . . . . . ........ 407
H. Paco Kang, MD
Kevin A. Raskin, MD, FAAOS
Chapter 35
Surgical Management of Lower
Extremity Metastatic Disease . . . ... 415
Francis R. Patterson, MD, FAAOS
Valdis M. Lelkes, MD, FAAOS
Chapter 36
Evaluation and Management
of Spinal Metastases . . . . . . ........ 425
Michael J. Vives, MD, FAAOS
John I. Shin, MD

Chapter 44
Bone Grafting, Bone Graft Substitutes,
and Growth Factors in Reconstruction
for Bone Defects . . . . . . . . . ......... 519
Steven Gitelis, MD, FAAOS
Alan Blank, MD, MS, FAAOS
Chapter 45
Surgical Management of Sarcomas
in Skeletally Immature Patients . . ... 533
Joel L. Mayerson, MD, FAAOS, FAOA
Ryan T. Voskuil, MD, FAAOS
Ernest U. Conrad III, MD, FAAOS, FACS
Chapter 46
Amputations . . . . . . . . . . ...........555
Stella J. Lee, MD
Richard L. McGough III, MD, FAAOS
Kurt R. Weiss, MD, FAAOS
Index . . . . . . . . . . . . . ............... 569