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This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments.
The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches.
Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.
Pages i-xi
Pages 1-1
George F. Muschler, Hannah Simmons, Venkata Mantripragada, Nicolas S. Piuzzi
Pages 3-28
Bone Marrow as a Source of Cells for Musculoskeletal Cellular Therapies
George F. Muschler, Hannah Simmons, Venkata Mantripragada, Nicolas S. Piuzzi
Pages 29-45
Adipose-Derived Stem/Stromal Cells, Stromal Vascular Fraction, and Microfragmented Adipose Tissue
Enrico Ragni, Marco Viganò, Paola De Luca, Edoardo Pedrini, Laura de Girolamo
Pages 47-61
Injections of Synovial Mesenchymal Stromal Cells
Ichiro Sekiya, Nobutake Ozeki
Pages 63-74
Placenta, Umbilical Cord, and Umbilical Cord Blood-Derived Cultured Stromal Cells
Jin-A Kim, Chul-Won Ha
Pages 75-87
Injectable Allogenic Mesenchymal Stromal Cells: Advantages, Disadvantages, and Challenges
Lucas K. Keyt, Matthew D. LaPrade, Aaron J. Krych, Daniel B. F. Saris
Pages 89-96
Tristan W. Juhan, Andrew J. Homere, Alexander E. Weber, George F. Hatch, Frank A. Petrigliano
Pages 97-107
Intra-articular Hyaluronic Acid Injections
Karan Vishwanath, Lawrence J. Bonassar
Pages 109-122
Cytokines, Chemokines, Alpha-2-Macroglobulin, Growth Factors
Claire D. Eliasberg, Scott A. Rodeo
Pages 123-132
Platelet-Rich Plasma: Processing and Composition
Spencer M. Stein, Bert R. Mandelbaum
Pages 133-143
Bogdan A. Matache, Eric J. Strauss, Jack Farr
Pages 145-154
Secretome, Extracellular Vesicles, Exosomes
Florien Jenner, Iris Ribitsch
Pages 155-166
Pages 167-168
Rotator Cuff Tendinopathy: Cell Therapy
Philippe Hernigou, Jacques Hernigou
Pages 169-179
Rotator Cuff Tendinopathy: Biologics
Pietro Simone Randelli, Chiara Fossati, Marianna Vitale, Francesca Pedrini, Alessandra Menon
Pages 181-189
Orthobiologics for the Treatment of Tennis Elbow
William D. Murrell, Sharmila Tulpule, Nagib Atallah Yurdi, Agnes Ezekwesili, Nicola Maffulli, Gerard A. Malanga
Pages 191-204
Patellar Tendinopathy: Cell Therapy
Chris H. Jo, Sanghoon Oh
Pages 205-214
Patellar Tendinopathy: Biologics
Rahman Kandil, Jason Dragoo
Pages 215-220
Orthobiologics for the Treatment of Achilles Tendinopathy
Joseph D. Lamplot, Cort D. Lawton, Scott A. Rodeo
Pages 221-236
Orthobiologics for the Treatment of Plantar Fasciitis
Filippo Rosati Tarulli, Cristian Aletto, Nicola Maffulli
Pages 237-243
Ligament Lesions: Cell Therapy
Robert S. Dean, Nicholas N. DePhillipo, Robert F. LaPrade
Pages 245-255
David Figueroa, Rodrigo Guiloff, Francisco Figueroa
Pages 257-263
Meniscal Lesions: Cell Therapy
Kazunori Shimomura, David A. Hart, Norimasa Nakamura
Pages 265-276
Stefano Zaffagnini, Alberto Poggi, Luca Andriolo, Angelo Boffa, Giuseppe Filardo
Pages 277-286
Orthobiologics for the Treatment of Muscle Lesions
Alberto Grassi, Giacomo Dal Fabbro, Stefano Zaffagnini
Pages 287-299
Cartilage Lesions and Osteoarthritis: Cell Therapy
Tiago Lazzaretti Fernandes, Kazunori Shimomura, David A. Hart, Angelo Boffa, Norimasa Nakamura
Pages 301-314
Cartilage Lesions and Osteoarthritis of the Knee: Biologics
Giuseppe Filardo, Angelo Boffa, Luca Andriolo, Alberto Poggi, Alessandro Di Martino
Pages 315-327
Cartilage Lesions and Osteoarthritis of the Hip and Ankle: Orthobiologics
Francesca Vannini, Simone Ottavio Zielli, Cesare Faldini
Pages 329-348
Kyle N. Kunze, Zaamin B. Hussain, Mikel Sánchez, Jorge Chahla
Pages 349-359
Injections: Orthobiologics and the Power of Placebo
Davide Previtali, Marco Cuzzolin, Giorgio Di Laura Frattura, Christian Candrian, Giuseppe Filardo
Pages 361-368
Pages 369-369
Pluripotent Stem Cells: Embryonic/Fetal Stem Cells and Induced Pluripotent Stem Cells
Gun-Il Im
Pages 371-381
Magali Cucchiarini
Pages 383-391
In Situ Targeting of Stem and Progenitor Cells in Native Tissues
Cierra A. Clark, Takeshi Oichi, Joshua M. Abzug, Satoru Otsuru
Pages 393-402
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