Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Neuroprotection and Neuroregeneration for Retinal Diseases
Nakazawa, Kitaoka, Harada
Editore
Springer
Anno
2014
Pagine
356
ISBN
9784431549642
120,00 €
- Offers the latest information on neuroprotection and regeneration for various eye diseases
- Treats both theoretical and practical aspects of the disease mechanisms and treatments
- Exhaustively reviews the key recent research into each eye disease by leading authors
This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve.
With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells.
This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.
Contents
Part I Neuroprotection for Glaucoma
1 Molecular Architecture of Glutamate Signaling Pathway
in Glaucomatous Optic Neuropathy . . . . . . . . . . . . . . . . . . . . . . . 3
Yasunari Munemasa
2 Calcium and Calpain Activation . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Morin Ryu and Toru Nakazawa
3 Classical Signaling Pathways . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Hideki Hayashi
4 Antioxidative Treatment for Neuroprotection in Glaucoma . . . . . 43
Kenya Yuki
5 ER Stress . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Masamitsu Shimazawa and Hideaki Hara
6 Nitric Oxide Contributes to Retinal Ganglion Cell Survival
Through Protein S-Nitrosylation After Optic Nerve Injury . . . . . 85
Yoshiki Koriyama and Satoru Kato
7 Neurotrophic Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Chikako Harada and Takayuki Harada
8 RIP Kinase-Mediated Programmed Necrosis . . . . . . . . . . . . . . . . 113
Yusuke Murakami, Maki Kayama, Joan W. Miller,
and Demetrios Vavvas
9 Axonal Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123
Yasushi Kitaoka
10 Axonal Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Yuji Takihara and Masaru Inatani
11 Interaction Between RGC Bodies and Glia . . . . . . . . . . . . . . . . . . . 143
Kenji Kashiwagi
12 Aquaporin in Optic Neuropathies . . . . . . . . . . . . . . . . . . . . . . . . . . 161
Akiyasu Kanamori
13 Microglia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
Yuki Fujita and Toshihide Yamashita
Part II Neuroprotection for Age-Related Macular Degeneration
(AMD), Retinal Pigmentary Degeneration
14 Neuroprotection for Photoreceptors . . . . . . . . . . . . . . . . . . . . . . . . 191
Toshiaki Abe and Nobuhiro Nagai
15 Retinal Photooxidative Stress and Its Modifiers . . . . . . . . . . . . . . . 205
Masaki Tanito
16 Roles of the Retinal Pigment Epithelium
in Neuroprotection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
Atsuhiro Kanda and Susumu Ishida
17 Oxidative Stress in the RPE and Its Contribution
to AMD Pathogenesis: Implication of Light Exposure . . . . . . . . . . 239
Yoko Ozawa
18 Interaction Between Photoreceptors and RPEs . . . . . . . . . . . . . . . . 255
Takeshi Yoshida and Kyoko Ohno-Matsui
Part III Neuroprotection for Other Retinal Diseases
19 Neuroprotection for Retinal Detachment . . . . . . . . . . . . . . . . . . . . 275
Toshio Hisatomi
20 Neuroinflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
Kazuichi Maruyama
21 Optic Neuritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307
Xiaoli Guo
22 Neuroprotection by Endothelial Progenitor Cells
for Retinal Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323
Shinichi Fukuda
23 Optic Nerve Regeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
Kazuhiko Namekata
